Forkhead Box Protein O1

A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.

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Networked: 115 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Haojie: 4 articles (01/2019 - 02/2005)
2.	Wang, Jian: 2 articles (02/2022 - 01/2019)
3.	Chay, Doo Byung: 2 articles (12/2019 - 11/2019)
4.	Cho, Hanbyoul: 2 articles (12/2019 - 11/2019)
5.	Chung, Joon-Yong: 2 articles (12/2019 - 11/2019)
6.	Han, Gwan Hee: 2 articles (12/2019 - 11/2019)
7.	Nam, Sanghee: 2 articles (12/2019 - 11/2019)
8.	Pan, Yunqian: 2 articles (01/2019 - 05/2011)
9.	Zhang, B: 2 articles (07/2015 - 06/2015)
10.	Cyr, Nicole E: 2 articles (03/2015 - 07/2014)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2021 - "Fat diet dampened mitophagy, promoted inflammation and phosphorylation of forkhead box protein O1 (FoxO1) and AMPKα1 (Ser485), the effects were eradicated by DKO. " 12/01/2018 - "Mechanistically, Sirt6 deficiency in macrophages caused an inflammation with increases in acetylation and protein stability of forkhead box protein O1. " 10/15/2013 - "These results suggest that inactivation of PrxII is important for the stability of FoxO1 protein, which subsequently mediates Foxp3(+) Treg cell development, thereby attenuating colonic inflammation. " 01/01/2022 - "RNA-sequencing analysis revealed FoxO1 (forkhead box protein O1) as the major proinflammatory transcriptional regulator activated by UCP2 knockdown, and FoxO1 inhibition reduced vascular inflammation and disturbed flow-enhanced atherosclerosis. " 01/01/2017 - "Dietary supplementation of LCP ameliorates inflammation and lipid peroxidation by upregulating nuclear factor (erythroid-derived 2)-like 2 and manganese-dependent superoxide dismutase, and downregulating forkhead box protein O1 and heme oxygenase-1 in NASH."
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "In this study, we examined the antitumor efficacy of QX in a mouse model of colorectal cancer and further investigated the mechanism by which QX regulated Foxo1 protein-mediated pathways. " 02/01/2015 - "MicroRNA-96 promotes the proliferation of colorectal cancer cells and targets tumor protein p53 inducible nuclear protein 1, forkhead box protein O1 (FOXO1) and FOXO3a."
3.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2021 - "Forkhead box protein O1 (FoxO1) /SERPINB1 ameliorates ROS production in diabetic nephropathy." 01/01/2018 - "Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy."
4.	Neoplasms (Cancer) 01/01/2019 - "Recent studies have shown that cytosolic forkhead box protein O1 (FoxO1) activates autophagy in cancer cells. " 01/01/2020 - "The forkhead box protein O1 (FOXO1) is considered to be a key tumor suppressor due to its involvement in a broad range of cancer-related functions, including cellular differentiation, apoptosis, cell cycle arrest, and DNA damage. " 11/01/2019 - "Patients with low FOXO1 protein levels were prone to have an advanced tumor stage (P = 0.049), higher ECOG ps (P = 0.024), the presence of bone marrow invasion (P = 0.000), and higher IPI (P = 0.035). " 01/01/2019 - "Foxo1 protein expression in tumors was also higher in the QX group than that in the vehicle control group. " 06/18/2015 - "Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. "
5.	Endometrial Neoplasms (Endometrial Cancer) 01/01/2010 - "Expression profiling of normal and malignant endometrial samples by quantitative real-time PCR and Northern blot analysis revealed an inverse correlation between the levels of FOXO1 protein and the abundance of several of the in silico-predicted miRs, suggesting that loss of FOXO1 expression in endometrial cancer may be mediated by miRs. " 08/01/2018 - "LINC00261 elevates FOXO1 protein levels through reducing FOXO1-targeted miRNAs to suppress endometrial carcinoma cell proliferation, migration, and invasion." 01/01/2022 - "Genistein inhibits cell growth by inducing cell cycle arrest in G2 and apoptosis; moreover, it upregulates prolonged expression of PR-B and forkhead box protein O1, regardless of estrogen receptor alpha expression in endometrial cancer cells. " 12/01/2016 - "Our study shows a marked loss of AMP-activated protein kinase (AMPK) phosphorylation and nuclear human Forkhead box O1 (FOXO1) protein in estrogen-dependent endometrial cancer (EC) tumors compared to normal control endometrium. "

Related Drugs and Biologics

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4.	Sirtuin 1
5.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
6.	Pro-Opiomelanocortin (Proopiomelanocortin)
7.	AMP-Activated Protein Kinases
8.	Phosphatidylinositols (Phosphatidylinositol)
9.	Peptides (Polypeptides)
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)