Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).

Also Known As:

Networked: 41 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alessi, Dario R: 4 articles (11/2020 - 01/2016)
2.	Dzamko, Nicolas: 3 articles (01/2018 - 01/2013)
3.	Halliday, Glenda M: 3 articles (01/2018 - 01/2013)
4.	Cookson, Mark R: 2 articles (01/2022 - 02/2016)
5.	Fell, Matthew J: 2 articles (01/2022 - 01/2016)
6.	Lewis, Patrick A: 2 articles (01/2022 - 01/2021)
7.	Bandopadhyay, Rina: 2 articles (01/2021 - 01/2017)
8.	Pfeffer, Suzanne R: 2 articles (01/2021 - 10/2019)
9.	Wawro, Paulina S: 2 articles (01/2021 - 10/2019)
10.	Yeshaw, Wondwossen M: 2 articles (01/2021 - 10/2019)

Related Diseases

1.	Parkinsonian Disorders (Parkinsonism) 07/01/2009 - "The Roc domain of the Lrrk2 protein harbors two pathogenic mutations which cause autosomal dominant parkinsonism (R1441C and R1441G). " 10/01/2007 - "Pathogenic substitutions in the Lrrk2 protein have been shown to be an important cause of both familial and sporadic parkinsonism. " 02/01/2006 - "Understanding the molecular function of the LRRK2 protein and its associated pathways might elucidate the switch between Lewy body pathology and neurofibrillary tangles, and holds promise for prospective therapeutics that might slow or halt progression of many forms of parkinsonism." 02/01/2016 - "In the period since LRRK2 (leucine-rich repeat kinase 2) was identified as a causal gene for late-onset autosomal dominant parkinsonism, a great deal of work has been aimed at understanding whether the LRRK2 protein might be a druggable target for Parkinson's disease (PD). "
2.	Colitis 03/01/2012 - "This genetic association precipitates an important functional study in which Liu et al. demonstrate that: LRRK2 acts as a negative regulator of NFAT in an NRON-dependent manner; LRRK2-deficient mice exhibit increased susceptibility to the development of dextran sodium sulfate colitis, which is enhanced by NFAT translocation to the nucleus; and patients exhibiting the risk LRRK2 allele have lower LRRK2 protein levels and exhibit less inhibition of NFAT. "
3.	Parkinson Disease (Parkinson's Disease) 10/17/2023 - "This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease." 01/01/2023 - "Mutations in the LRRK2 protein cause Parkinson's disease (PD). " 04/02/2021 - "A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels." 01/01/2021 - "LRRK2 protein is expressed prominently in immune cells, cell types whose contribution to LRRK2-associated genetic Parkinson's disease (PD) is increasingly being recognised. " 01/01/2020 - "Since the discovery of LRRK2 mutations causal to Parkinson's disease (PD) in the early 2000s, the LRRK2 protein has been implicated in a plethora of cellular processes in which pathogenesis could occur, yet its physiological function remains elusive. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 02/08/2017 - "Although the physiological function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in neurodegenerative diseases, including PD. " 01/01/2009 - "The pleomorphic features exhibited by LRRK2 mutation carriers and the central role of Lrrk2 protein in the proper functioning of central nervous system suggest that mutations in this protein might be involved in multiple cellular processes leading to other neurodegenerative disorders than PD. " 01/01/2023 - "Missense mutations along the leucine-rich repeat kinase 2 (LRRK2) protein are a major contributor to Parkinson's Disease (PD), the second most commonly occurring neurodegenerative disorder worldwide. " 11/09/2023 - "Genetic mutation of the leucine-rich repeat kinase 2 (LRRK2) protein has been associated with Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder that is devoid of efficacious disease-modifying therapies. " 01/01/2022 - "The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope and efficacy. "
5.	Lewy Body Disease (Lewy Body Dementia) 07/29/2007 - "The anatomical distribution of Lrrk2 protein may provide insight into its function in health and neurodegeneration, thus we performed a comparative study with 'in-house' and commercially available Lrrk2 antibodies using brain tissue from wild type and human Lrrk2 transgenic bacterial artificial chromosome (BAC) mice, and from diffuse Lewy body disease (DLBD) patients. "

Related Drugs and Biologics

1.	Dextrans (Dextran)
2.	sodium sulfate (sodium bisulfate)
3.	Phosphotransferases (Kinase)
4.	Leucine (L-Leucine)
5.	Proteins (Proteins, Gene)
6.	Synucleins
7.	GTP Phosphohydrolases (GTPases)
8.	Sphingolipids
9.	Phospholipids (Phosphatides)
10.	Guanosine

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy