Promyelocytic Leukemia Protein

A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.

Also Known As:

Networked: 159 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kao, Hung-Ying: 11 articles (01/2018 - 02/2008)
2.	Cheng, Xiwen: 5 articles (08/2014 - 01/2012)
3.	Liu, Yu: 5 articles (08/2014 - 02/2008)
4.	Shih, Hsiu-Ming: 4 articles (12/2021 - 04/2013)
5.	Herzer, Kerstin: 4 articles (01/2019 - 06/2008)
6.	Pandolfi, Pier Paolo: 4 articles (01/2015 - 04/2003)
7.	Reineke, Erin L: 4 articles (03/2010 - 02/2008)
8.	Chang, Kun-Sang: 4 articles (02/2008 - 05/2002)
9.	Papamatheakis, Joseph: 3 articles (01/2022 - 01/2019)
10.	Zhong, Liang: 3 articles (09/2017 - 02/2017)

Related Diseases

1.	Infections 10/01/2017 - "Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection." 11/01/2016 - "MCPyV replication most likely depends on subnuclear structures such as promyelocytic leukemia protein nuclear bodies (PML-NBs), which are known to play regulatory roles in the infection of many DNA viruses. " 11/01/2013 - "Promyelocytic leukemia protein modulates establishment and maintenance of latent gammaherpesvirus infection in peritoneal cells." 04/01/2005 - "Infections with DNA viruses commonly result in the association of viral genomes and replication compartments with cellular nuclear substructures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10. " 07/20/2004 - "Furthermore, a drug that modifies the behavior of the related promyelocytic leukemia protein PML specifically rescues infection by viruses restricted by human TRIM5alpha. "
2.	Heart Failure 01/01/2023 - "Our previous study uncovered that promyelocytic leukemia protein (PML)-associated SUMO processes is a new regulator of cardiac hypertrophy and heart failure. "
3.	Cardiomegaly (Heart Hypertrophy) 01/01/2023 - "Our previous study uncovered that promyelocytic leukemia protein (PML)-associated SUMO processes is a new regulator of cardiac hypertrophy and heart failure. "
4.	Neoplasms (Cancer) 10/01/2023 - "Promyelocytic leukemia protein (PML) modulates diverse cell functions that contribute to both tumor suppressor and pro-oncogenic effects, depending on the cellular context. " 01/01/2022 - "Promyelocytic leukemia protein (PML) and stem cells: from cancer to pluripotency." 12/06/2021 - "Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. " 01/01/2021 - "In this volume of Clinical Science, Karle et al. demonstrate that tumor suppressor, promyelocytic leukemia protein (PML) plays an important role in regulation of VSMC phenotype and response to inflammatory stimuli (Clin Sci (2021) 135(7), 887-905; DOI: 10.1042/CS20201399). " 01/01/2019 - "Promyelocytic leukemia protein deficiency leads to spontaneous formation of liver tumors in hepatitis C virus transgenic mice."
5.	Acute Promyelocytic Leukemia 09/28/2015 - "Promyelocytic leukemia protein (PML) is central to ATO treatment efficacy of acute promyelocytic leukemia. " 02/01/2004 - "The promyelocytic leukemia protein (PML)-nuclear body is a cellular structure that is disrupted during the pathogenesis of acute promyelocytic leukemia, a disease characterized by impaired myeloid cell differentiation. " 09/28/2001 - "The promyelocytic leukemia protein (PML) is a mammalian regulator of cell growth which is characteristically disrupted in acute promyelocytic leukemia and by a variety of viruses. " 07/01/2023 - "We also discuss how altered condensate formation contributes to malignant transformation of hematopoietic cells, as described for promyelocytic leukemia protein (PML) in PML::RARA-driven acute promyelocytic leukemia (APL) and other myeloid malignancies. " 03/26/2010 - "Promyelocytic leukemia protein (PML) was originally identified as part of a chromosomal translocation that contributes to the development of acute promyelocytic leukemia (APL). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	DNA (Deoxyribonucleic Acid)
3.	Antiviral Agents (Antivirals)
4.	Viral Proteins
5.	Tumor Viral Antigens (Large T Antigen)
6.	transcriptional intermediary factor 1
7.	Retinoic Acid Receptor alpha
8.	Retinoic Acid Receptors (Retinoic Acid Receptor)
9.	Arsenic Trioxide (Trisenox)
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)