ADAMTS1 Protein

An ADAMTS protease that contains two disintegrin loops and three C-terminal thrombospondin (TS) motifs. It functions as an ANGIOGENESIS INHIBITOR as well as in normal tissue growth and fertility.

Also Known As:

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ricciardelli, Carmela: 2 articles (01/2019 - 12/2011)
2.	Russell, Darryl L: 2 articles (01/2019 - 12/2011)
3.	Frewin, Kate: 1 article (01/2019)
4.	Tan, Izza A: 1 article (01/2019)
5.	Chang, Xiaojing: 1 article (02/2013)
6.	Chen, Jing: 1 article (02/2013)
7.	Dai, Dongqiu: 1 article (02/2013)
8.	Zhang, Shuanglong: 1 article (02/2013)
9.	Zhi, Yu: 1 article (02/2013)
10.	Freitas, Vanessa M: 1 article (01/2013)

Related Diseases

1.	Ameloblastoma 01/01/2022 - "This study showed a distinct expression of ADAMTS-1 and versican in ameloblastoma and DF, with ADAMTS-1 protein higher expression observed in ameloblastoma and possibly cleaved versican. "
2.	Neoplasms (Cancer) 02/01/2013 - "A negative correlation was also found between ADAMTS1 protein expression and MVD in primary gastric tumors. " 12/01/2011 - "The ADAMTS1 protease gene is required for mammary tumor growth and metastasis." 01/05/2013 - "In a series of primary breast tumors, we observed variable levels of ADAMTS-1 mRNA expression but lower levels of ADAMTS-1 protein expression in human breast cancers as compared to normal tissue, with a striking decrease observed in high-malignancy cases (triple-negative for estrogen, progesterone and Her-2). "
3.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "We assessed ADAMTS1 mRNA levels in publically available breast cancer sets and analysed ADAMTS1 protein levels by immunohistochemistry in breast tissue microarrays containing normal breast tissue (n=9), primary invasive ductal breast carcinomas (n=79) and metastatic lesions (n=58). " 01/05/2013 - "In a series of primary breast tumors, we observed variable levels of ADAMTS-1 mRNA expression but lower levels of ADAMTS-1 protein expression in human breast cancers as compared to normal tissue, with a striking decrease observed in high-malignancy cases (triple-negative for estrogen, progesterone and Her-2). "
4.	Neoplasm Metastasis (Metastasis) 12/01/2011 - "The ADAMTS1 protease gene is required for mammary tumor growth and metastasis."
5.	Lung Neoplasms (Lung Cancer) 01/01/2023 - "si-TGF-β or inhibition of TGF-β expression through the short peptide KTFR on ADAMTS1 protein could reverse the oncogenic effects of ADAMTS1 on lung cancer cells. "

Related Drugs and Biologics

1.	Versicans (Versican)
2.	Messenger RNA (mRNA)
3.	Progesterone
4.	Peptides (Polypeptides)
5.	Estrogens (Estrogen)