ADAMTS Proteins

A subfamily of ADAM proteases that are distinguished by the presence of one or more THROMBOSPONDIN type-1 repeats (TSRs). These are three-strand motifs that contain characteristic TRYPTOPHAN, ARGININE, and CYSTEINE residues respectively. In contrast to ADAM proteins, which reside on CELL MEMBRANES, ADAMTS proteases are secreted and function in the EXTRACELLULAR MATRIX.

Also Known As:

A Disintegrin And Metalloproteinase With Thrombospondin Motifs Proteins; ADAMTS Proteases; ADAMTS-Like Proteins; ADAMTSL Proteins; Adam Metallopeptidases With Thrombospondin Type 1 Motif Proteins; ADAMTS Like Protein; ADAMTS Like Proteins; Protease, ADAMTS; Protein, ADAMTS; Protein, ADAMTS-Like; Protein, ADAMTSL; A Disintegrin And Metalloproteinase With Thrombospondin Motifs Protein; ADAMTS Protease; ADAMTS Protein; ADAMTS-Like Protein; ADAMTSL Protein; Adam Metallopeptidases With Thrombospondin Type 1 Motif Protein

Networked: 41 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Apte, Suneel S: 9 articles (11/2021 - 04/2006)
2.	Le Goff, Carine: 3 articles (12/2021 - 04/2006)
3.	Hubmacher, Dirk: 3 articles (01/2021 - 09/2015)
4.	Peris-Torres, Carlos: 2 articles (02/2021 - 03/2020)
5.	Rodríguez-Manzaneque, Juan Carlos: 2 articles (02/2021 - 03/2020)
6.	Cal, Santiago: 2 articles (05/2015 - 10/2007)
7.	López-Otín, Carlos: 2 articles (05/2015 - 10/2007)
8.	Ashlin, Tim G: 2 articles (10/2013 - 12/2010)
9.	Kwan, Alvin P L: 2 articles (10/2013 - 12/2010)
10.	Ramji, Dipak P: 2 articles (10/2013 - 12/2010)

Related Diseases

1.	Inflammation (Inflammations) 07/01/2006 - "Because genetic studies have shown that ADAM-33 gene polymorphisms are associated with asthma, we designed this study to assess mRNA expression profile of several ADAM and ADAMTS proteases in sputum from patients with asthma and to investigate the relationship between expression of these proteases and asthma-associated inflammation and airway obstruction. " 01/01/2021 - "Significant differences in the levels of site-specific N-glycans on inflammation-associated components [IgM, IgG1, IgG2, complement components 8b (CO8B) and attractin], central nerve system-damage-related serum proteins [apolipoprotein D (APOD), alpha-1-antitrypsin, plasma kallikrein and ADAMTS-like protein 3] were observed among three study groups. "
2.	Osteoarthritis 06/01/2020 - "Studies have reported the role of ADAMTS proteases in osteoarthritis and atherosclerotic lesions.In" 01/01/2022 - "The Mechanism and Role of ADAMTS Protein Family in Osteoarthritis." 05/01/2009 - "Thus, the propeptide processing mechanism of ADAMTS5 has several points of distinction from those of other ADAMTS proteases, which may have considerable significance in the context of osteoarthritis." 03/31/2005 - "The relative contribution of individual ADAMTS proteases to cartilage destruction during osteoarthritis has not been resolved. " 08/01/2018 - "The overproduction of MMPs (matrix metalloproteinases) and members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family plays an important role in the pathogenesis of osteoarthritis (OA). "
3.	Asthma (Bronchial Asthma) 07/01/2006 - "Because genetic studies have shown that ADAM-33 gene polymorphisms are associated with asthma, we designed this study to assess mRNA expression profile of several ADAM and ADAMTS proteases in sputum from patients with asthma and to investigate the relationship between expression of these proteases and asthma-associated inflammation and airway obstruction. "
4.	Airway Obstruction (Choking) 07/01/2006 - "Because genetic studies have shown that ADAM-33 gene polymorphisms are associated with asthma, we designed this study to assess mRNA expression profile of several ADAM and ADAMTS proteases in sputum from patients with asthma and to investigate the relationship between expression of these proteases and asthma-associated inflammation and airway obstruction. "
5.	Neoplasms (Cancer) 10/01/2021 - "The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis." 02/01/2021 - "ADAMTS proteases and the tumor immune microenvironment: Lessons from substrates and pathologies." 01/01/2021 - "ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and its expression is frequently silenced due to promoter hypermethylation in various human cancers. " 05/01/2015 - "ADAMTS proteases and cancer." 01/01/2009 - "This review covers recent developments in the involvement of ADAM and ADAMTS proteins in human cancer."

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Apolipoproteins D (Apo D)
3.	Plasma Kallikrein
4.	Messenger RNA (mRNA)
5.	Polysaccharides (Glycans)
6.	Immunoglobulin M (IgM)
7.	Immunoglobulin G (IgG)
8.	Complement System Proteins (Complement)
9.	Blood Proteins (Serum Proteins)
10.	Versicans (Versican)