Lipocalin-2

A lipocalin of approximately 200 amino acids that functions as an iron transporter and is expressed by cells of BONE MARROW and many other cells with secretory functions. It is involved in APOPTOSIS and may function to limit pathogenic bacterial growth as part of the INNATE IMMUNE RESPONSE.

Also Known As:

Networked: 2783 relevant articles (62 outcomes, 392 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Devarajan, Prasad: 46 articles (01/2022 - 12/2004)
2.	Xu, Aimin: 21 articles (01/2021 - 01/2007)
3.	Suk, Kyoungho: 20 articles (05/2022 - 01/2009)
4.	Buemi, Michele: 19 articles (01/2016 - 01/2007)
5.	Barasch, Jonathan: 18 articles (12/2021 - 12/2004)
6.	Wang, Yu: 18 articles (08/2020 - 01/2007)
7.	Bellomo, Rinaldo: 17 articles (12/2020 - 07/2009)
8.	Ronco, Claudio: 17 articles (12/2020 - 01/2008)
9.	Berger, Thorsten: 17 articles (01/2018 - 02/2006)
10.	Mori, Kiyoshi: 16 articles (11/2017 - 12/2004)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 04/15/2020 - "To establish an absolute quantification method for neutrophil gelatinase-associated lipocalin (NGAL) by ultra-high-performance liquid chromatography tandem positive ion electrospray ionization mass spectrometry (UHPLC/MS/MS) and evaluate its diagnostic efficacy for acute kidney injury (AKI). " 04/15/2020 - "Absolute quantification of urinary neutrophil gelatinase-associated lipocalin by ultra-high-performance liquid chromatography/tandem mass spectrometry and the diagnostic efficacy of acute kidney injury." 01/01/2016 - "In our adjusted models, enrollment neutrophil gelatinase-associated lipocalin level was independently associated with survival even after controlling for the development of acute kidney injury, and its addition to clinical models improved overall predictive accuracy. " 01/01/2015 - "Blood neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be helpful for acute kidney injury (AKI) in pediatric patients and adults. " 02/01/2014 - "Acute kidney injury prediction improved when urine neutrophil gelatinase-associated lipocalin was added to a clinical model (area under the curve increased at 1 hr from 0.85 to 0.91 and at 3 hr to 0.92). "
2.	Inflammation (Inflammations) 01/01/2021 - "However, fecal CALP and Lipocalin-2 (LCN-2) concentrations were significantly greater in the induced inflammation groups at 28-d. " 01/01/2019 - "IL-22BP-/- mice exhibited decreased inflammation, increased lipocalin 2 expression, and deletion of IL-22BP was associated with preserved epithelial barrier function with evidence of improved tight junction stability. " 01/01/2022 - "In this study, we aimed to explore the effects of Lipocalin-2 (LCN2) on ferroptosis-mediated inflammation and oxidative stress in neonatal ARDS and the potential mechanism. " 06/01/2021 - "This study aimed to determine whether neutrophil gelatinase-associated lipocalin (NGAL) values better predict mortality in septic patients when combined with inflammation-based prognostic scores. " 03/01/2017 - "Aim of the study was to investigate the associations between serum lipocalin-2 levels and the disease activity, markers of inflammation or metabolic disturbances and changes after topical treatment in psoriatic patients. "
3.	Neoplasms (Cancer) 06/01/2020 - "In the current study, 158 tumor tissues from NPC patients were collected and immunohistochemistry was performed to determine the NGAL protein expression, to investigate the correlation between its expression and clinical and pathological parameters using Chi square analysis. " 01/01/2019 - "Our preliminary studies demonstrate that lipocalin-2 may be of value in the diagnostics of uterine body cancers." 03/02/2017 - "Some studies have reported differentially altered neutrophil gelatinase-associated lipocalin (NGAL) levels in several malignancies. " 09/01/2015 - "In this study we assess lipocalin-2 expression in 2 renal tumor types and analyze its association with clinicopathological parameters and prognosis. " 05/01/2013 - "Neutrophil gelatinase-associated lipocalin (NGAL) expression is increased in epithelial cancer patients, but studies showing its relation to prognosis are scarce. "
4.	Albuminuria 01/01/2021 - "SFK inhibition by KF-1607 prevented the progression of tubular injury in UUO mice, as indicated by decreases in albuminuria, urinary KIM-1 excretion, and kidney NGAL protein expression. " 01/01/2019 - "Glomerular filtration rate, urinary NGAL (neutrophil gelatinase-associated lipocalin), and albuminuria were unaffected by treatment. " 01/01/2017 - "Albuminuria and urinary neutrophil gelatinase-associated lipocalin (uNGAL) were estimated after 2-4 h and 1 week after ESWL. " 04/01/2016 - "Nephropathy was characterized by abnormalities including hyperfiltration, albuminuria, increased urinary neutrophil gelatinase-associated lipocalin (NGAL), upregulation of renal fibrotic markers, and glomerulosclerosis. " 03/01/2015 - "We aimed at evaluating the level of urine neutrophil gelatinase-associated lipocalin (NGAL) as a marker of tubulointerstitial damage in children and adolescents with type 1 DM in relation to the level of albuminuria and other parameters. "
5.	Fibrosis (Cirrhosis) 11/01/2020 - "Utility of Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) in Decompensated Cirrhosis." 01/01/2020 - "DAPA slowed the loss of renal function, mitigated renal tubular injury markers (kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin), and reduced tubulointerstitial fibrosis. " 09/01/2015 - "Lipocalin-2 may be involved in renal dysfunction and dermal fibrosis of SSc. " 07/01/2015 - "The Central Role of Neutrophil Gelatinase-Associated Lipocalin in Cardiovascular Fibrosis." 09/25/2012 - "To explore the expression and significance of neutrophil gelatinase-associated lipocalin(NGAL)in renal interstitial fibrosis (RIF) in rats. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Creatinine
3.	Proteins (Proteins, Gene)
4.	Cystatin C
5.	Lipocalin-2
6.	Fatty Acid-Binding Proteins
7.	Interleukin-18 (Interleukin 18)
8.	Matrix Metalloproteinase 9 (Gelatinase B)
9.	Urea (Carbamide)
10.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Nephrectomy
4.	Drug Therapy (Chemotherapy)
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)