Hemochromatosis Protein

A membrane protein and MHC class I antigen. It contains an IMMUNOGLOBULIN C1-SET DOMAIN and interacts with BETA 2-MICROGLOBULIN. It may also regulate the interaction of TRANSFERRIN with the TRANSFERRIN RECEPTOR. Mutations in the HFE gene are associated with cases of FAMILIAL HEMOCHROMATOSIS.

Also Known As:

Networked: 59 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Enns, Caroline A: 5 articles (04/2010 - 03/2003)
2.	Gao, Junwei: 3 articles (04/2010 - 08/2008)
3.	Anderson, Gregory J: 2 articles (04/2021 - 04/2015)
4.	Bardou-Jacquet, Edouard: 2 articles (04/2021 - 03/2014)
5.	Allen, Katrina J: 2 articles (01/2019 - 04/2015)
6.	Bertalli, Nadine A: 2 articles (01/2019 - 04/2015)
7.	Delatycki, Martin B: 2 articles (01/2019 - 04/2015)
8.	English, Dallas R: 2 articles (01/2019 - 04/2015)
9.	Giles, Graham G: 2 articles (01/2019 - 04/2015)
10.	Gurrin, Lyle C: 2 articles (01/2019 - 04/2015)

Related Diseases

1.	Hemochromatosis (Bronze Diabetes) 04/01/2000 - "This study was performed to examine the expression of HFE protein in epithelial cells, macrophages, and circulating leukocytes obtained from normal subjects and patients with hereditary hemochromatosis. " 10/01/2018 - "Although the relationship between hereditary hemochromatosis and mutations in the HFE gene was discovered more than 20 years ago, information on the in vivo regulation of HFE protein expression is still limited. " 01/01/2018 - "Haemochromatosis is most commonly due to the autosomal recessive inheritance of a C282Y substitution in the HFE protein, whereby both alleles of the corresponding gene are affected. " 04/01/2017 - "R2*-relaxometry of the pancreas in patients with human hemochromatosis protein associated hereditary hemochromatosis." 01/01/2017 - "Immunofluorescence showed that colocalization of β2M, and the hemochromatosis gene (HFE) protein was observed on A549 cells. "
2.	Iron Overload 11/20/2020 - "HFE protein levels were increased in Alk3fl/fl;Alb-Cre mice compared to Alk3fl/fl mice, which was caused by iron overload - and not by Alk3 deficiency. " 12/15/2015 - "We review HFE mapping and cloning, structure, promoters and controllers, and coding region mutations, HFE protein structure, cell and tissue expression and function, mouse Hfe knockouts and knockins, and HFE mutations in other mammals with iron overload. " 03/01/2009 - "Patients with the most common form of hereditary iron overload have mutations in the hereditary hemochromatosis protein HFE. " 08/01/2008 - "Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of HFE expression in the liver. " 09/01/2005 - ": The existence in our proband of a partly-altered HFE protein in the region encoded by exon 2 might be responsible for the histologically-demonstrated iron overload."
3.	Cardiomyopathies (Cardiomyopathy) 01/01/2017 - "Hemochromatosis Protein (HFE) Knockout Mice As a Novel Model of Hemochromatosis: Implications for Study and Management of Iron-Overload Cardiomyopathy."
4.	Hepatocellular Carcinoma (Hepatoma) 04/17/2000 - "Overexpression of hemochromatosis protein, HFE, alters transferrin recycling process in human hepatoma cells." 04/17/2000 - "In order to elucidate the role of HFE protein on cellular iron metabolism, functional studies were carried out in human hepatoma cells (HLF) overexpressing a fusion gene of HFE and green fluorescent protein (GFP). "
5.	Iron Deficiencies 10/01/2018 - "The purpose of the study was to determine the response of liver HFE protein content to iron deficiency in mice and rats by immunoblotting. " 10/01/2018 - "NEW & NOTEWORTHY Feeding of iron-deficient diet for 4 wk decreased liver HFE protein content in both mice and rats, suggesting that decreased HFE-dependent signaling may contribute to hepcidin downregulation in iron deficiency. "

Related Drugs and Biologics

1.	Iron
2.	Green Fluorescent Proteins
3.	Carrier Proteins (Binding Protein)
4.	Hepcidins
5.	Transferrin Receptors (Transferrin Receptor)
6.	Transferrin (beta 2 Transferrin)
7.	Proteins (Proteins, Gene)
8.	metal transporting protein 1 (ferroportin)
9.	Peptide Hydrolases (Proteases)
10.	Hormones (Hormone)