Member 1 Subfamily G ATP Binding Cassette Transporter

ATP binding cassette transporter that functions primarily as a lipid and CHOLESTEROL exporter in MACROPHAGES. It may also function in intracellular lipid transport and homoeostasis.

Also Known As:

ATP Binding Cassette Transporter, Subfamily G, Member 1; ABCG1 Protein; ABCG1 Transporter; ATP Binding Cassette Transporter, Sub-Family G, Member 1; ATP-Binding Cassette Transporter 8; White Protein Homolog; ATP Binding Cassette Transporter 8

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Frisdal, Eric: 2 articles (10/2015 - 09/2012)
2.	Le Goff, Wilfried: 2 articles (10/2015 - 09/2012)
3.	Kawakami, Yasushi: 1 article (08/2017)
4.	Suzuki, Kana: 1 article (08/2017)
5.	Yamauchi, Kazuyoshi: 1 article (08/2017)
6.	Fang, Qingxin: 1 article (06/2017)
7.	Huang, Di: 1 article (06/2017)
8.	Tian, Chunyan: 1 article (06/2017)
9.	Xie, Chao: 1 article (06/2017)
10.	Yu, Yanli: 1 article (06/2017)

Related Diseases

1.	Hyperthyroidism 07/01/2008 - "The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7alpha-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [(3)H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1."
2.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2011 - "Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study."
3.	Lung Neoplasms (Lung Cancer) 06/01/2017 - "The present study showed that ABCG1 protein is upregulated in lung cancer compared with adjacent normal tissues and furthermore, aberrant ABCG1 expression was detected in lung cancer cell lines. "
4.	Atherosclerosis 08/01/2017 - "These alterations, especially the induction of ABCG1 protein, may be closely involved with the development of atherosclerosis." 01/01/2014 - "[ABCG1 transporter gene expression in peripheral blood mononuclear cells of patients with atherosclerosis]."
5.	Inborn Genetic Diseases (Disease, Hereditary) 09/01/2012 - "The physiological function of the ATP-binding cassette G1 (ABCG1) transporter in humans is not yet elucidated, as no genetic disease caused by ABCG1 mutations has been documented. "

Related Drugs and Biologics

1.	ATP Binding Cassette Transporter 1
2.	ATP-Binding Cassette Transporters (ABC Transporters)
3.	Sterols
4.	Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)
5.	Irinotecan (Camptosar)
6.	Cholesterol
7.	Adenosine Triphosphate (ATP)
8.	Messenger RNA (mRNA)