Tensins

A family of multidomain microfilament proteins that bind ACTIN FILAMENTS and INTEGRINS at FOCAL ADHESIONS. They generally consist of an N-terminal domain with homology to PHOSPHOTYROSINE PHOSPHATASE, a C2 DOMAIN; unique central regions rich in PROLINE; ALANINE; GLYCINE; and SERINE; an SH2 DOMAIN; and a C-terminal phosphotyrosine-binding region. They are involved in CELL MIGRATION; CELL ADHESION; SIGNAL TRANSDUCTION; and reorganization of the CYTOSKELETON.

Also Known As:

Networked: 2664 relevant articles (36 outcomes, 313 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eng, Charis: 34 articles (01/2022 - 11/2002)
2.	Pandolfi, Pier Paolo: 14 articles (12/2021 - 10/2002)
3.	Wu, Hong: 14 articles (01/2018 - 01/2006)
4.	Li, Li: 11 articles (01/2022 - 01/2003)
5.	Zhang, Jing: 9 articles (01/2022 - 05/2007)
6.	Ngeow, Joanne: 9 articles (01/2021 - 02/2012)
7.	Kitagishi, Yasuko: 9 articles (09/2020 - 01/2013)
8.	Matsuda, Satoru: 9 articles (09/2020 - 01/2013)
9.	Sauter, Guido: 9 articles (01/2020 - 08/2012)
10.	Schlomm, Thorsten: 9 articles (01/2020 - 08/2012)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2014 - "C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. " 01/01/2023 - "In this review we focus on the role of tensins in normal and cancer cells. " 01/01/2023 - "The expression of tensins varies among cancers. " 01/01/2023 - "The role of tensins in malignant neoplasms." 01/01/2023 - "To understand the role of Tensin 1-3 in neoplasia, current molecular evidence is categorized by the hallmarks of cancer model. "
2.	Carcinogenesis 01/01/2009 - "Moreover, tumorigenesis in the human kidney may be facilitated by a general downregulation of Tensins. " 01/01/2021 - "COOH-terminus tensin-like molecule (CTEN) is a member of the tensin family, which is considered to be one of the novel proto-oncogenes involved in tumorigenesis and cancer progression. " 01/01/2023 - "Drosophila as Model System to Study Ras-Mediated Oncogenesis: The Case of the Tensin Family of Proteins." 03/01/2019 - "In this study, we found that miR-183-5p could promote lung carcinogenesis by directly targeting phosphatase tensin (PTEN). " 11/02/2023 - "MP31, a phosphatase and tensin homolog (PTEN) uORF-translated and mitochondria-localized micropeptide, disrupted the MQC process and inhibited GBM tumorigenesis. "
3.	Glioblastoma (Glioblastoma Multiforme) 10/01/2015 - "The study aimed to explore the specific function and mechanism of miR-144-3p in glioblastoma (GBM) cells with different phosphatase and tensin homolog (PTEN) phenotypes. " 01/03/2006 - "Our previous study suggests that the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene, one of the most frequently mutated genes in glioblastomas, restricts neural stem/progenitor cell proliferation in vivo. " 01/01/2023 - "Deletions or loss-of-function mutations in phosphatase and tensin homolog (PTEN) are common in glioblastoma (GBM) and have been associated with defective DNA damage repair. " 01/01/2023 - "Among the TERTp-wild-type glioblastoma samples, we observed a significant difference in median progression-free survival (18.6 and 11.4 months, respectively) and overall survival (not reached and 15.7 months, respectively) in patients with and without phosphatase and tensin homolog (PTEN) loss and/or mutation. " 01/01/2021 - "Contradictory Effect of Notch1 and Notch2 on Phosphatase and Tensin Homolog and its Influence on Glioblastoma Angiogenesis."
4.	Inflammation (Inflammations) 06/28/2023 - "The results suggest that miR-22-3p may regulate inflammation by regulating phosphatase and tensin homologue (PTEN), an important regulatory molecule in the PI3K/AKT pathway, and downregulating the expression of NLRP3. " 01/01/2023 - "miR-27a-5p alleviates periodontal inflammation by targeting phosphatase and tensin homolog deleted on chromosome ten." 05/01/2020 - "The miRNet and Reactome databases identified phosphatase and tensin homolog as a major common pathway, indicating inflammation as a central hallmark. " 02/01/2018 - "The results indicated that EGCG may suppress inflammation and inflammatory cell infiltration into the lungs of OVA‑challenged asthmatic mice, and may also inhibit EMT via the PI3K/Akt signaling pathway through upregulating the expression of phosphatase and tensin homolog (PTEN) in vivo and in vitro. " 01/01/2018 - "Liver-specific phosphatase and tensin homolog (PTEN)-deletion mice (PTENLKO) or control littermates were fed a standard chow diet for 45-55 weeks followed by analysis for liver injury, oxidative stress and inflammation. "
5.	Prostatic Neoplasms (Prostate Cancer) 09/15/2023 - "This study investigates the function of HLF in prostate cancer (PCa) and its relation to tensin 1 (TNS1). " 06/15/2007 - "Human prostate cancer PC3 cells are deficient in tensin relative to fibroblasts and have fewer, mostly peripheral adhesions. " 03/25/2023 - "Purpose: The aim of our study was to observe the associations between the ETS-related gene (ERG) and the phosphatase and tensin homolog gene (PTEN) immunoexpression in prostate cancer and related lesions and highlight the clinical significance of these findings. " 06/01/2019 - "The objective of our study was to investigate whether phosphatase and tensin homolog (PTEN) expression is associated with clinicopathologic features and multiparametric MRI findings in prostate cancer. " 01/13/2018 - "In the present study, we explored the effects of PLCε on PTEN (phosphatase and tensin homolog deleted on chromosome 10) in cell proliferation in prostate cancer cells. "

Related Drugs and Biologics

1.	Phosphoric Monoester Hydrolases (Phosphatases)
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	PTEN Phosphohydrolase (PTEN Phosphatase)
5.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
6.	Messenger RNA (mRNA)
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Sirolimus (Rapamycin)
9.	Caspase 3 (Caspase-3)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics
2.	Adjuvant Chemotherapy
3.	Radiotherapy
4.	Castration
5.	Drug Therapy (Chemotherapy)