Discoidins

Lectins that were identified in DICTYOSTELIUM DISCOIDEUM. They bind to GALACTOSE and are involved in cell-substratum adhesion, maintenance of morphology during aggregation, and spore formation.

Also Known As:

Networked: 30 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ballif, Bryan A: 2 articles (10/2020 - 11/2017)
2.	Ebert, Alicia M: 2 articles (10/2020 - 11/2017)
3.	Schmoker, Anna M: 2 articles (10/2020 - 11/2017)
4.	Weinert, Jaye L: 2 articles (10/2020 - 11/2017)
5.	Weir, Marion E: 2 articles (10/2020 - 11/2017)
6.	Bae, Joon Seol: 2 articles (04/2012 - 04/2012)
7.	Cheong, Hyun Sub: 2 articles (04/2012 - 04/2012)
8.	Kim, Jeong-Hyun: 2 articles (04/2012 - 04/2012)
9.	Park, Byung-Lae: 2 articles (04/2012 - 04/2012)
10.	Park, Choon-Sik: 2 articles (04/2012 - 04/2012)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2020 - "Results from the present study identified eight important genes that may guide treatment decisions regarding chemotherapy regimens for ovarian cancer, including epidermal growth factor-like repeats and discoidin I-like domains 3, NRAS proto-oncogene, hyaluronan and proteoglycan link protein 1, activated protein C receptor, CD53, cyclin-dependent kinase inhibitor 2A, insulin-like growth factor 1 receptor and roundabout guidance receptor 2 genes. "
2.	Neoplasms (Cancer) 01/01/2021 - "Accumulating evidence shows that the elevated expression of DCBLD2 (discoidin, CUB and LCCL domain-containing protein 2) is associated with unfavorable prognosis of various cancers. " 10/01/2020 - "The Discoidin, CUB, and LCCL domain-containing protein (DCBLD) family consists of two type-I transmembrane scaffolding receptors, DCBLD1 and DCBLD2, which play important roles in development and cancer. " 01/01/2008 - "Moreover, in vitro matrigel and in vivo chorioallantoic membrane assays showed that silencing of PCA-1 significantly downregulated discoidin receptor (DDR)-1 expression, resulting in suppression of cancer-cell invasion. " 09/01/2017 - "Among them, we further focused on discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2), a receptor tyrosine kinase with aberrant expression in malignant tumors. " 01/26/2016 - "Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3), an extracellular matrix (ECM) protein associated with vascular morphogenesis and remodeling, is commonly upregulated in multiple types of human cancers and correlates with tumor progression. "
3.	Starvation 01/01/1993 - "Induction of the discoidin promoter by starvation in the rap1 transformants also resulted in spread flat cells. " 06/01/1984 - "Although MC2 cells are defective in nutrient uptake under restrictive conditions, the overproduction of discoidin I did not appear to be part of a pleiotropic response to starvation. " 11/16/2000 - "This defect correlated with loss of discoidin Igamma mRNA, a starvation-induced gene, although other genes required for development were expressed normally or even precociously. " 10/01/2008 - "The social amoeba Dictyostelium discoideum adopts a cohesive stage upon starvation and then produces Discoidin I and II, two proteins able to bind galactose and N-acetyl-galactosamine. "
4.	Breast Neoplasms (Breast Cancer) 11/15/1993 - "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain." 06/15/1993 - "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain." 01/01/2020 - "We performed a differential gene expression analysis comparing paclitaxel-resistant vs. paclitaxel-sensitive breast cancer cells that showed the upregulation of EDIL3 (EGF Like Repeats and Discoidin I Like Domains Protein 3). "
5.	Vascular Remodeling 11/21/2017 - "Discoidin, CUB, and LCCL domain containing 2 (DCBLD2) is a neuropilin-like transmembrane scaffolding receptor with known and anticipated roles in vascular remodeling and neuronal positioning. "

Related Drugs and Biologics

1.	Epidermal Growth Factor (EGF)
2.	Cyclin-Dependent Kinase Inhibitor p16
3.	Proteoglycans (Proteoglycan)
4.	Hyaluronic Acid (Hyaluronan)
5.	Insulin-Like Peptides
6.	activated protein C receptor
7.	link protein
8.	Proteins (Proteins, Gene)
9.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
10.	Programmed Cell Death 1 Receptor

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics