Discoidin Domain Receptor 2

A discoidin domain receptor for FIBRILLAR COLLAGEN and non-fibrillar COLLAGEN TYPE X. It functions in many cellular and developmental processes that include remodeling of the EXTRACELLULAR MATRIX; CELL MIGRATION; CELL DIFFERENTIATION; and CELL PROLIFERATION; as well as OSTEOGENESIS and the maturation of CHONDROCYTES.

Also Known As:

CD167b Antigen; DDR2 Kinase; DDR2 Protein; Discoidin Domain Receptor Family, Member 2 Protein; Discoidin Domain Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase, Receptor-Related 3 Protein; Tyrosine Kinase Receptor Type 10; Antigen, CD167b; Kinase, DDR2; Neurotrophic Tyrosine Kinase, Receptor Related 3 Protein; Protein, DDR2

Networked: 122 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yao, Libo: 11 articles (01/2018 - 11/2002)
2.	Su, Jin: 10 articles (11/2019 - 10/2006)
3.	Li, Yefu: 8 articles (12/2021 - 01/2005)
4.	Xu, Lin: 8 articles (12/2021 - 01/2005)
5.	Bu, Xin: 7 articles (01/2020 - 03/2014)
6.	Liu, Xinping: 7 articles (12/2014 - 11/2002)
7.	Zhang, Wei: 6 articles (01/2020 - 10/2006)
8.	Longmore, Gregory D: 5 articles (10/2021 - 06/2013)
9.	Zhang, Jian: 5 articles (12/2014 - 10/2006)
10.	Zhang, Jing: 4 articles (01/2019 - 01/2013)

Related Diseases

1.	Rheumatoid Arthritis 06/01/2005 - "To investigate the expression of discoidin domain receptor 2 (DDR2) of fibroblast-like synovial cells in improved adjuvant-induced animal (AIA) model for rheumatoid arthritis (RA) and to provide evidence for DDR2's antagonist use clinically. " 06/01/2005 - "Regular expression of discoidin domain receptor 2 in the improved adjuvant-induced animal model for rheumatoid arthritis." 11/01/2002 - "Functional analysis of discoidin domain receptor 2 in synovial fibroblasts in rheumatoid arthritis." 09/01/2014 - "Discoidin domain receptor 2 (DDR-2)/matrix metalloproteinase (MMP) signaling is an important pathway involved in cartilage destruction in rheumatoid arthritis (RA). " 10/01/2009 - "Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis."
2.	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/01/2013 - "RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats."
3.	Neoplasms (Cancer) 01/01/2016 - "Previous studies have suggested that discoidin domain receptor 2 (DDR2) is related to tumor progression and EMT. " 05/01/2022 - "One recurrent tumor included an additional TP53 mutation and the other recurrent tumor showed POLE and DDR2 kinase gene mutation. " 01/01/2022 - "Discoidin Domain Receptor 2: A New Target in Cancer." 06/18/2021 - "The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer." 01/01/2017 - "The synthesized compounds were screened for DDR1 and DDR2 kinase inhibitory and cancer cell proliferation inhibitory activities. "
4.	Osteoarthritis 12/01/2021 - "Targeting Discoidin Domain Receptor 2 for the Development of Disease-Modifying Osteoarthritis Drugs." 09/01/2020 - "Delay in articular cartilage degeneration of the knee joint by the conditional removal of discoidin domain receptor 2 in a spontaneous mouse model of osteoarthritis." 11/01/2016 - "Discoidin Domain Receptor 2 as a Potential Therapeutic Target for Development of Disease-Modifying Osteoarthritis Drugs." 04/01/2014 - "To determine whether reduction of the discoidin domain receptor 2 (Ddr2) delays the progression of condylar cartilage degeneration in the temporomandibular joint (TMJ) of mouse models with osteoarthritis (OA). " 09/01/2010 - "Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice."
5.	Ovarian Neoplasms (Ovarian Cancer) 05/20/2021 - "Discoidin domain receptor 2 (DDR2) expression is upregulated in ovarian cancer tissues, and is closely associated with poor clinical outcomes in ovarian cancer patients. " 01/01/2019 - "Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer." 01/01/2016 - "Prognostic significance of discoidin domain receptor 2 (DDR2) expression in ovarian cancer." 01/01/2018 - "TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis." 05/20/2021 - "Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness."

Related Drugs and Biologics

1.	Collagen
2.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
3.	Collagen Receptors
4.	Fibrillar Collagens
5.	Proteins (Proteins, Gene)
6.	ErbB Receptors (EGF Receptor)
7.	Protein-Tyrosine Kinases (Tyrosine Kinase)
8.	Phosphotransferases (Kinase)
9.	Dasatinib (BMS 354825)
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Precision Medicine
4.	Lasers (Laser)
5.	Aftercare (After-Treatment)