Discoidin Domain Receptor 1

A discoidin domain receptor for FIBRILLAR COLLAGEN that functions in a variety of cellular processes. For example, it regulates cell attachment to the EXTRACELLULAR MATRIX, remodeling of the extracellular matrix, CELL MIGRATION; CELL DIFFERENTIATION; CELL PROLIFERATION; and CELL SURVIVAL.

Also Known As:

Networked: 143 relevant articles (1 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bendeck, Michelle P: 7 articles (01/2020 - 05/2008)
2.	Chatziantoniou, Christos: 7 articles (01/2019 - 12/2006)
3.	Arimura, Kimiyoshi: 7 articles (11/2008 - 05/2005)
4.	Higashimoto, Ikkou: 7 articles (11/2008 - 05/2005)
5.	Shirahama, Yuko: 7 articles (11/2008 - 05/2005)
6.	Fridman, Rafael: 6 articles (09/2021 - 01/2018)
7.	Watanabe, Masaki: 6 articles (11/2008 - 05/2005)
8.	Matsuyama, Wataru: 6 articles (01/2007 - 10/2003)
9.	Belfiore, Antonino: 5 articles (01/2021 - 06/2015)
10.	Morrione, Andrea: 5 articles (01/2021 - 06/2015)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 11/01/2023 - "Discoidin domain receptor tyrosine kinase 1 (DDR1) is involved in adhesion, proliferation, differentiation, migration, and metastasis in several cancers. " 01/01/2022 - "Discoidin domain receptor 1 (DDR1) has been demonstrated to be able to promote tumor invasion and metastasis and being closely related to tumor immune infiltration. " 10/01/2018 - "Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma." 01/01/2018 - "Signaling by discoidin domain receptor 1 in cancer metastasis." 01/01/2019 - "Mechanistically, circ-NSD2 acted as a sponge for the tumour suppressor miR-199b-5p and activated DDR1 (discoidin domain receptor tyrosine kinase 1) and JAG1 (Jagged 1) genes, which synergistically helped with cell-matrix interaction, migration and metastasis of CRC cells. "
2.	Fibrosis (Cirrhosis) 01/01/2018 - "Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis." 05/01/2010 - "In several experimental studies, it has been suggested that discoidin domain receptor 1 (DDR1) plays an important role in the regulation of mesangial proliferation, glomerular basement membrane thickening, renal fibrosis, and in the development of inflammation in several tissue types, including renal tissues. " 01/01/2017 - "The Role of Discoidin Domain Receptor 1 in Inflammation, Fibrosis and Renal Disease." 02/16/2016 - "We have previously demonstrated that abnormal expression of the Discoidin Domain Receptor 1 (DDR1) is a key factor of renal disease by promoting inflammation and fibrosis. " 07/01/2011 - "Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy."
3.	Neoplasms (Cancer) 11/24/2021 - "BACKGROUND Previous studies showed that the discoidin domain receptor tyrosine kinase 1 (DDR1) is significantly elevated in a variety of cancers, and it is closely related to the occurrence and development of tumors. " 01/01/2022 - "Discoidin domain receptor 1 (DDR1) is upregulated in multiple cancers and positively associated with chemoresistance. " 01/01/2019 - "2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy." 01/01/2018 - "A putative role for Discoidin Domain Receptor 1 in cancer chemoresistance." 01/01/2011 - "Depletion of discoidin domain receptor 1 (DDR1) blocks collective cancer-cell invasion in a range of two-dimensional, three-dimensional and 'organotypic' models. "
4.	Inflammation (Inflammations) 05/01/2010 - "In several experimental studies, it has been suggested that discoidin domain receptor 1 (DDR1) plays an important role in the regulation of mesangial proliferation, glomerular basement membrane thickening, renal fibrosis, and in the development of inflammation in several tissue types, including renal tissues. " 01/01/2017 - "The Role of Discoidin Domain Receptor 1 in Inflammation, Fibrosis and Renal Disease." 02/16/2016 - "We have previously demonstrated that abnormal expression of the Discoidin Domain Receptor 1 (DDR1) is a key factor of renal disease by promoting inflammation and fibrosis. " 07/01/2011 - "Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy." 01/01/2022 - "Imatinib mesylate is a novel ophthalmic formulation of imatinib mesylate, which is expected to alleviate inflammation by inhibiting the discoidin domain receptor 1 activity. "
5.	Hepatocellular Carcinoma (Hepatoma) 11/24/2021 - "Discoidin Domain Receptor Tyrosine Kinase 1 (DDR1): A Novel Predictor for Recurrence of Hepatocellular Carcinoma After Curative Resection." 01/01/2020 - "To investigate the function of discoidin domain receptor 1 (DDR1) in hepatocellular carcinoma (HCC) and to further clarify the underlying mechanism. " 08/27/2010 - "Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion." 02/01/2022 - "Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway." 01/01/2022 - "Discoidin Domain Receptor 1, a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma."

Related Drugs and Biologics

1.	Jagged-1 Protein
2.	Collagen Receptors
3.	Protein-Tyrosine Kinases (Tyrosine Kinase)
4.	ErbB Receptors (EGF Receptor)
5.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
6.	Integrins
7.	Erythropoietin
8.	Biomarkers (Surrogate Marker)
9.	Collagen Type IV (Type IV Collagen)
10.	Cell Adhesion Molecules

Related Therapies and Procedures

1.	Therapeutics