Discoidin Domain Receptors

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.

Also Known As:

Networked: 140 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fridman, Rafael: 5 articles (11/2020 - 06/2012)
2.	Bendeck, Michelle P: 4 articles (01/2020 - 05/2002)
3.	Sohail, Anjum: 3 articles (11/2020 - 01/2019)
4.	Leitinger, Birgit: 3 articles (01/2018 - 02/2012)
5.	Buache, Emilie: 3 articles (05/2016 - 01/2016)
6.	El Btaouri, Hassan: 3 articles (05/2016 - 01/2016)
7.	Garnotel, Roselyne: 3 articles (05/2016 - 01/2016)
8.	Jeannesson, Pierre: 3 articles (05/2016 - 01/2016)
9.	Morjani, Hamid: 3 articles (05/2016 - 01/2016)
10.	Saby, Charles: 3 articles (05/2016 - 01/2016)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2020 - "Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease." 08/01/2014 - "Improvement in cardiac function by Let-7c inhibitor postinfarction was associated with decreased apoptosis, reduced fibrosis, and reduction in the number of discoidin domain receptor 2-positive fibroblasts, while the number of c-kit(+) cardiac stem cells and Ki-67(+) proliferating cells remained unaltered. " 08/15/2006 - "Discoidin domain receptor 1-deficient mice are resistant to bleomycin-induced lung fibrosis." 02/01/2023 - "This study aimed to clarify the role of crosstalk between discoidin domain receptors (DDRs) and matrix metalloproteinases (MMPs) in the ligamentum flavum (LF) fibrosis obtained from patients with degenerative lumbar canal stenosis (DLCS). " 02/01/2023 - "Effects of Expression of Matrix Metalloproteinases and Discoidin Domain Receptors in Ligamentum Flavum Fibrosis in Patients with Degenerative Lumbar Canal Stenosis."
2.	Inflammation (Inflammations) 10/15/2017 - "Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models." 11/10/2021 - "Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation." 05/16/2023 - "Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer's disease." 01/01/2021 - "Discoidin domain receptors (DDR1 and DDR2) are the collagen receptors of the family tyrosine kinases, which play significant role in the diseases like inflammation, fibrosis and cancer. " 01/01/2013 - "Use of the pharmacological inhibitor imatinib, which targets the Abl family of non-receptor tyrosine kinases (Abl and Arg), as well as other tyrosine kinases including the platelet-derived growth factor receptor (PDGFR), Kit, colony stimulating factor 1 receptor (CSF1R), and discoidin domain receptors, has shown protective effects in animal models of inflammation, sepsis, and other pathologies characterized by enhanced vascular permeability. "
3.	Sepsis (Septicemia) 01/01/2013 - "Use of the pharmacological inhibitor imatinib, which targets the Abl family of non-receptor tyrosine kinases (Abl and Arg), as well as other tyrosine kinases including the platelet-derived growth factor receptor (PDGFR), Kit, colony stimulating factor 1 receptor (CSF1R), and discoidin domain receptors, has shown protective effects in animal models of inflammation, sepsis, and other pathologies characterized by enhanced vascular permeability. "
4.	Neoplasms (Cancer) 01/01/2023 - "Tumoral expression of a panel of DDR proteins including BRCA1, BRCA2, ATM, and p53 with immunohistochemistry was evaluated and association with patient and tumor features as well as prognosis was assessed. " 01/01/2023 - "We assessed the prognostic and predictive potential of tumoral expression of DDR proteins along with clinical and tumor characteristics in patients with resected PC. " 01/01/2022 - "ER-α deficiency associated persistence of DNA lesions and reduced expression of DDR proteins were validated in human mammary tumors." 10/01/2021 - "Prognostic and Clinicopathologic Significance of Discoidin Domain Receptors in Different Human Malignancies: A Meta-Analysis." 05/01/2021 - "After comparing the cancer mutation frequency and conservation of DDR proteins, Mre11 was selected for functional screening. "
5.	Breast Neoplasms (Breast Cancer) 06/09/2015 - "We and others have noticed that aberrant subcellular localisation of DNA damage response (DDR) proteins in breast cancer (BC) is associated with loss-of-function phenotype. " 02/01/2015 - "Receptor kinases Discoidin Domain Receptors (DDRs) 1 and 2 are emerging as new therapeutic targets in breast cancer (BC). " 09/01/2011 - "In this study, status of DNA damage response (DDR)-associated proteins was examined in breast cancer subtypes in association with clinical features; 479 breast cancers were examined for expression of DDR proteins γH2AX, BRCA1, pChk2, and p53, DNA damage-sensitive tumor suppressors Fhit and Wwox, and Wwox-interacting proteins Ap2α, Ap2γ, ErbB4, and correlations among proteins, tumor subtypes, and clinical features were assessed. " 01/01/2018 - "Interestingly, CDK12 protein absence was associated with reduced expression of a number of DDR proteins including ATR, Ku70/Ku80, PARP1, DNA-PK, and γH2AX, suggesting a novel mechanism of CDK12-associated DDR dysregulation in breast cancer. " 01/01/2016 - "Using a genetic approach, we show that, in mice, the action of the fibrillar collagen receptor discoidin domain receptor 2 (DDR2) in both tumor and tumor-stromal cells is critical for breast cancer metastasis yet does not affect primary tumor growth. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Tyrosine (L-Tyrosine)
3.	tyrosine receptor (receptor, tyrosine)
4.	Imatinib Mesylate (Gleevec)
5.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
6.	Macrophage Colony-Stimulating Factor
7.	DNA (Deoxyribonucleic Acid)
8.	Proteins (Proteins, Gene)
9.	DNA-Activated Protein Kinase
10.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Electroacupuncture