Perilipin-5

A perilipin that functions in LIPOGENESIS; LIPOLYSIS; and fatty acid oxidation in BROWN ADIPOSE TISSUE; heart, liver, and skeletal muscle. It recruits MITOCHONDRIA to the surface of LIPID DROPLETS where it functions in both the storage of fatty acids as TRIGLYCERIDES, and their release for mitochondrial fatty acid oxidation in response to metabolic needs.

Also Known As:

Networked: 34 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weiskirchen, Ralf: 3 articles (05/2021 - 03/2019)
2.	Asimakopoulou, Anastasia: 2 articles (01/2020 - 03/2019)
3.	Kalampoka, Stavroula: 2 articles (01/2020 - 03/2019)
4.	Bickel, Perry E: 2 articles (01/2016 - 10/2011)
5.	Dutta, Sucharita: 2 articles (10/2015 - 04/2015)
6.	Imai, Yumi: 2 articles (10/2015 - 04/2015)
7.	Machida, Yui: 2 articles (10/2015 - 04/2015)
8.	Trevino, Michelle B: 2 articles (10/2015 - 04/2015)
9.	Barker, T A: 2 articles (06/2014 - 02/2013)
10.	Cocks, M: 2 articles (06/2014 - 02/2013)

Related Diseases

1.	Inflammation (Inflammations) 07/01/2022 - "Perilipin 5 (Plin5) acts as a pivotal mediator of oxidative stress and inflammation and is associated with the progression of relevant diseases. " 12/01/2021 - "Perilipin 5 (Plin5) exerts a vital role in numerous pathological conditions via affecting cell apoptosis, oxidative stress, and inflammation. " 11/01/2019 - "Perilipin 5 deficiency promotes atherosclerosis progression through accelerating inflammation, apoptosis, and oxidative stress." 12/01/2021 - "Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation."
2.	Insulin Resistance 04/01/2022 - "Perilipin 5 (PLIN5) is one of the most critical agents in such regulation, being often referred as a protector against lipotoxicity and consequent skeletal muscle insulin resistance. " 01/01/2019 - "Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice." 12/06/2016 - "We show that PLIN5 protein is elevated in endurance-trained (ET) subjects and correlates with muscle oxidative capacity and whole-body insulin sensitivity. " 10/01/2015 - "Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice." 02/01/2013 - "This study first investigated the hypothesis that ET-induced increases in net IMTG breakdown and insulin sensitivity are related to increased expression of perilipin 2 (PLIN2) and perilipin 5 (PLIN5). "
3.	Non-alcoholic Fatty Liver Disease 05/18/2023 - "Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease." 05/17/2021 - "Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights." 01/01/2020 - "Deletion of Perilipin 5 Protects Against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation." 01/01/2016 - "Accordingly, a reduction in Notch1 and increase in glucose-6-phosphatase and perilipin-5 expression was observed in liver biopsies from NAFLD/NASH compared with controls. " 01/01/2020 - "Perilipin 5 (PLIN5), a known lipid droplet coating protein and triglyceride metabolism regulator, is highly expressed in oxidatively modified tissues but it is still unclear how it affects NAFLD/NASH progress. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2016 - "Thus, reduced FA use in heart failure may result from improper delivery, potentially via decreased perilipin 5 expression and mitochondrial-LD tethering, and not from intrinsic mitochondrial dysfunction.-Holzem, K. " 01/01/2016 - "We propose that Perilipin 5 is an important molecular link that couples the coordinated catecholamine activation of the PKA pathway and of lipid droplet lipolysis with transcriptional regulation to promote efficient fatty acid catabolism and prevent mitochondrial dysfunction." 01/01/2021 - "Here, we reveal that palmitate (PA) induces an increase in expression of the FA transport protein cluster of differentiation 36 (CD36) and LD formation; remarkably reduces the expression of lipases involved in triacylglycerol (TAG) lipolysis, such as adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL); impairs LD-mitochondria interaction; and decreases perilipin 5 (PLIN5) expression, resulting in LD accumulation and mitochondrial dysfunction, which ultimately lead to cardiomyocyte apoptosis. "
5.	Atherosclerosis 01/01/2022 - "Perilipin 5 (Plin5), a regulator of lipid metabolism, is also confirmed to be involved in vascular disorders, such as microvascular endothelial dysfunction and atherosclerosis. " 11/01/2019 - "Perilipin 5 deficiency promotes atherosclerosis progression through accelerating inflammation, apoptosis, and oxidative stress."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Perilipin-2
3.	Proteins (Proteins, Gene)
4.	Triglycerides (Triacylglycerol)
5.	Lipids
6.	Lipase (Acid Lipase)
7.	Perilipin-1
8.	Inflammasomes
9.	Myostatin
10.	Leptin

Related Therapies and Procedures

1.	Endurance Training