Perilipin-2

A perilipin that is expressed by many different cell types. It binds FATTY ACIDS and CHOLESTEROL, stabilizes TRIGLYCERIDES, and localizes to both the surface and hydrophobic core of LIPID DROPLETS, as well as the ENDOPLASMIC RECTICULUM and PLASMA MEMBRANE in MACROPHAGES. It also plays a central role in the biogenesis of lipid droplets and FOAM CELLS and is highly expressed by macrophages at atherosclerotic lesions in human arteries along with the INFLAMMATION markers TNF-ALPHA; MCP-1 RECEPTOR; and IL-6.

Also Known As:

Networked: 221 relevant articles (9 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kharasch, Evan D: 6 articles (12/2019 - 05/2010)
2.	Morrissey, Jeremiah J: 6 articles (12/2019 - 05/2010)
3.	Yao, Kenshi: 5 articles (07/2021 - 03/2013)
4.	Ahima, Rexford S: 5 articles (01/2014 - 05/2007)
5.	Ishida, Mitsuaki: 4 articles (04/2022 - 04/2019)
6.	Tsuta, Koji: 4 articles (04/2022 - 04/2019)
7.	Fujimoto, Masakazu: 4 articles (10/2021 - 01/2017)
8.	Severino, Anna: 4 articles (08/2021 - 01/2016)
9.	Jakobiec, Frederick A: 4 articles (01/2019 - 01/2014)
10.	McManaman, James L: 4 articles (01/2019 - 01/2013)

Related Diseases

1.	Carcinoma (Carcinomatosis) 04/01/2014 - "To determine the efficacy of adipophilin immunohistochemistry in the diagnosis of sebaceous carcinoma of the ocular adnexal region and to provide the guidelines for interpretation of this immunostain. " 11/01/2018 - "Unlike their benign counterparts, sebaceous carcinomas coexpressed CK5/6 and adipophilin. " 01/01/2017 - "The carcinoma cells without the vacuoles showed a subnuclear dot-like expression for adipophilin in CV-PTC cases, but not in the con-PTC cases. " 04/01/2014 - "The specificity and sensitivity of adipophilin immunostaining in the diagnosis of sebaceous carcinoma were both 100% when more than 5% of the staining occurred in vacuoles (<95% granular staining). " 04/01/2014 - "Sebaceous carcinomas demonstrated significantly stronger adipophilin expression, a greater number of intracytoplasmic vacuoles, and larger vacuoles. "
2.	Neoplasms (Cancer) 04/25/2021 - "The aim of this study was to evaluate the association of MWM with epithelial intracellular lipid droplets (immunohistochemically stained by adipose differentiation-related protein (ADRP)) and histological tumor grades. " 12/01/2015 - "The authors previously reported that the white opaque substance (WOS) in gastric epithelial neoplasia was caused by accumulation of lipid droplets by immunohistochemical and immunoelectron microscopic studies of adipophilin, which was recently identified and validated as a marker of lipid droplets. " 11/01/2015 - "Our study indicates that adipophilin represents a sensitive and reliable marker for the diagnosis of SC and can be of help in separating this tumor from some of its mimics. " 03/01/2013 - "The present study confirmed that the presence of WOS in gastric neoplasias was dependent upon intramucosal accumulation of lipid droplets using anti-adipophilin staining. " 04/01/2010 - "This study examines adipophilin expression in various sebaceous lesions and other cutaneous tumors with a clear cell histology that may mimic sebaceous differentiation. "
3.	Fatty Liver 02/01/2006 - "Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein." 02/24/2006 - "The present study was performed to examine a role of adipose differentiation-related protein (ADRP) in the process of liver steatosis. " 01/01/2022 - "The preventive effects of ICAE on fatty liver are concerned with the downregulation of PPARγ and ADRP protein expression in liver." 01/01/2019 - "Hepatocyte-specific and extra-hepatocyte actions of perilipin-2 during fatty liver disease: benefits of being extra." 01/01/2019 - "Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions."
4.	Atherosclerosis 12/13/2018 - "This study supports previous findings that reduction of perilipin 2 expression is protective against atherogenesis, while finding an unexpected increase in lipid droplet size with reduced perilipin 2 expression." 01/01/2018 - "In this explorative study, PLIN2 protein levels are significantly increased in patients with neoatherosclerosis, irrespective of clinical presentation, implicating that it might play a pathogenetic role in accelerated atherosclerosis after DES implantation. " 01/01/2021 - "Perilipin 2 (PLIN2) regulates intracellular lipid metabolism in macrophages, and thus, plays a role in atherosclerosis. " 01/01/2021 - "We found that perilipin-2 and FABP4 are expressed by acute atherosis foam cells, similar to atherosclerosis, supporting possible shared pathways for foam cell generation. " 01/01/2015 - "Adipose differentiation-related protein (ADRP) is intrinsically associated with the surface of lipid droplets implicated in the development of atherosclerosis. "
5.	Insulin Resistance 01/01/2016 - "The perilipin 2 (PLIN2) gene Ser251Pro missense mutation is associated with reduced insulin secretion and increased insulin sensitivity in Italian obese subjects." 10/01/2009 - "Muscle OXPAT and ADRP protein content was examined during the development of insulin resistance in Zucker diabetic fatty (ZDF) rats and in type 2 diabetes patients and BMI-matched control subjects. " 02/01/2013 - "This study first investigated the hypothesis that ET-induced increases in net IMTG breakdown and insulin sensitivity are related to increased expression of perilipin 2 (PLIN2) and perilipin 5 (PLIN5). " 02/01/2010 - "Taken together, the results obtained in the present study indicate that adipophilin protein expression in muscle is involved in maintaining insulin sensitivity." 07/01/2013 - "Insulin resistance was associated with hepatic steatosis, increased ceramide levels, and Perilipin 2 expression. "

Related Drugs and Biologics

1.	Lipids
2.	Androgen Receptors (Androgen Receptor)
3.	Fatty Acid Synthases (Fatty Acid Synthase)
4.	Carrier Proteins (Binding Protein)
5.	Sterols
6.	Messenger RNA (mRNA)
7.	Flavonoids
8.	Keratin-5 (Keratin 5)
9.	Diglycerides
10.	Acyltransferases

Related Therapies and Procedures

1.	Gastric Bypass (Roux-en-Y Gastric Bypass)
2.	Stents
3.	Endurance Training
4.	Resistance Training
5.	Drug-Eluting Stents