Perilipin-1

A lipid droplet protein that is expressed primarily by ADIPOCYTES of WHITE ADIPOSE TISSUE and BROWN ADIPOSE TISSUE. It co-localizes with MACROPHAGES and FOAM CELLS of artherosclerotic lesions and stabilizes LIPID DROPLETS by inhibiting HORMONE SENSITIVE LIPASE. It may also protect TRIGLYCERIDES against hydrolysis within the PLASMA MEMBRANE and modulate CHOLESTEROL ESTER HYDROLASE activity.

Also Known As:

Networked: 193 relevant articles (7 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Greenberg, Andrew S: 7 articles (08/2018 - 08/2003)
2.	Ordovas, Jose M: 7 articles (12/2008 - 11/2004)
3.	Qi, Lu: 5 articles (05/2008 - 11/2004)
4.	Savage, David B: 4 articles (12/2019 - 02/2011)
5.	Geng, Bin: 4 articles (01/2016 - 01/2013)
6.	Xu, Guoheng: 4 articles (01/2016 - 01/2013)
7.	Corella, Dolores: 4 articles (06/2006 - 11/2004)
8.	Vigouroux, Corinne: 3 articles (12/2019 - 02/2011)
9.	Schirmacher, Peter: 3 articles (01/2019 - 03/2010)
10.	Zhao, Xiaojing: 3 articles (01/2016 - 01/2015)

Related Diseases

1.	Insulin Resistance 03/01/2016 - "The HF-L group had a greater body mass (BM) gain, insulin resistance, increased gene expression related to lipogenesis (CD36, aP2, SREBP1c, and FAS), decreased gene expression of perilipin in both eWAT and sWAT, and reduced expression of genes related to beta-oxidation (CPT-1a) and to mitochondrial biogenesis (PGC1alpha, NRF1, and TFAM) in eWAT and sWAT. " 07/01/2015 - "G-Rb1 may improve insulin sensitivity in obese and diabetic db/db mice by reducing hepatic fat accumulation and suppressing adipocyte lipolysis; these effects may be mediated via the upregulation of perilipin expression in adipocytes." 01/01/2013 - "Human congenital perilipin deficiency and insulin resistance." 04/01/2010 - "The increased lipolytic action may accelerate FFA efflux from the adipose tissues to the bloodstream, thereby accounting for systemic FFA elevation and, hence, insulin resistance in perilipin null mice." 04/01/2010 - "An increase in the score for the homeostasis model assessment of insulin resistance index confirmed the insulin resistance in perilipin null mice, which may be attributed to the plasma FFA elevation. "
2.	Obesity 01/01/2014 - "In silico discovery of a perilipin 1 inhibitor to be used as a new treatment for obesity." 01/01/2014 - "The aim of this study is to use computational servers and software to predict the 3D structure of perilipin 1 and predict potential inhibitors to be used as treatment of obesity. " 01/01/2014 - "Study of perilipin functions has provided insight into the physiological roles of cytosolic lipid droplets and their relationship with obesity-related pathologies. " 01/01/2013 - "This study was aimed to replicate the associations between three Perilipin Gene (PLIN) variants (rs894160, rs1052700, and rs2304796) and diabetes risks and to evaluate the overall effects of these variants on diabetes risk and obesity risk. " 09/01/2008 - "Some studies shown that lower level of perilipin protein was displayed in obese than lean subjects and polymorphisms in PLIN were associated with obesity in American and Spanish white women as well as in Korean . "
3.	Weight Loss (Weight Reduction) 09/01/2005 - "Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction." 09/01/2005 - "The objective of the study was to examine the association of several polymorphisms at the perilipin (PLIN) locus with obesity and weight reduction in response to a low-energy diet in obese patients. " 03/23/2009 - "Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance." 12/01/2008 - "Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents." 10/01/2023 - "RS2289487 variation in PERILIPIN gene is a predictor of weight loss and protection against impaired glucose metabolism after a meal-replacement diet in postmenopausal obese females."
4.	Sarcoma (Soft Tissue Sarcoma) 01/01/2020 - "The combined application of whole perilipin family immunohistochemistry may help to distinguish differently differentiated sarcomas." 02/01/2017 - "Perilipin 1 is a highly specific marker for adipocytic differentiation in sarcomas with intermediate sensitivity." 01/01/2019 - "Perilipin 1 Expression Differentiates Liposarcoma from Other Types of Soft Tissue Sarcoma." 02/01/2017 - "However, perilipin 1 appeared to be a highly specific marker for liposarcoma and adipocytic differentiation in sarcomas with intermediate sensitivity." 02/01/2017 - "Eighty-seven cases of liposarcomas and 30 cases of non-lipomatous sarcomas were investigated immunohistochemically for perilipin 1 and 2 using entire tissue sections. "
5.	Carcinoma (Carcinomatosis) 09/01/2013 - "On the other hand, perilipin expression was seen in 13 (43%) of 30 sebaceous carcinoma and only 1 hidradenocarcinoma. " 09/01/2013 - "We investigated the expression of adipophilin and perilipin in 101 cutaneous carcinomas. " 09/01/2013 - "Perilipin and adipophilin expression in sebaceous carcinoma and mimics." 09/01/2013 - "Although specific for invasive sebaceous carcinoma, perilipin expression was not helpful in distinguishing sebaceous carcinoma in situ from squamous cell carcinoma in situ with clear cell change. " 08/01/2021 - "Immunohistochemistry for perilipin 1 and adipophilin was performed in 12 human tooth germs (TG), 27 conventional ameloblastoma (AM), and 8 ameloblastic carcinoma (AC) samples. "

Related Drugs and Biologics

1.	Lipids
2.	Glucose (Dextrose)
3.	Adiponectin
4.	Acetyl-CoA Carboxylase
5.	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)
6.	Phosphoenolpyruvate
7.	Collagen
8.	Coenzyme A Ligases (Acid-Thiol Ligases)
9.	Proteins (Proteins, Gene)
10.	Perilipin-2

Related Therapies and Procedures

1.	Endurance Training
2.	Resistance Training
3.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
4.	Fat-Restricted Diet (Diet, Fat Restricted)
5.	Immunotherapy