Coxa Magna

Deformity of the hip characterized by enlargement and deformation of the FEMUR HEAD and FEMUR NECK, often with associated changes in the ACETABULUM. These changes may be secondary to other diseases (e.g. LEGG-PERTHES DISEASE; ARTHRITIS; HIP DISLOCATION, CONGENITAL) or TRAUMA.

Also Known As:

Networked: 54 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Congenital Abnormalities (Deformity)
2.	Hip Dislocation
3.	Osteonecrosis (Kienbock's Disease)
4.	Legg-Calve-Perthes Disease (Perthes Disease)
5.	Osteoarthritis

Experts

1.	Kim, Harry K W: 11 articles (05/2020 - 03/2005)
2.	Bauss, Frieder: 3 articles (01/2007 - 03/2005)
3.	Bian, Haikuo: 3 articles (01/2007 - 03/2005)
4.	Cho, Tae-Joon: 2 articles (05/2016 - 09/2012)
5.	Choi, In Ho: 2 articles (05/2016 - 09/2012)
6.	Yoo, Won Joon: 2 articles (05/2016 - 09/2012)
7.	Fan, Meng: 2 articles (10/2013 - 08/2012)
8.	Jiang, Wen-xue: 2 articles (10/2013 - 08/2012)
9.	Lu, Shi-bi: 2 articles (10/2013 - 08/2012)
10.	Peng, Jiang: 2 articles (10/2013 - 08/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Coxa Magna:

1.	Diphosphonates (Bisphosphonates)IBA 01/01/2007 - "Because IOFH is a localized condition, there is a need to explore the therapeutic potential of local, intraosseous administration of bisphosphonate to prevent the femoral head deformity. " 09/01/2012 - "In this systematic review, we answered the following questions: (1) Does bisphosphonate (BP) therapy decrease femoral head deformity and improve pain and function in LCPD or other juvenile osteonecrotic conditions? " 07/01/2006 - "Recent studies show that bisphosphonates can decrease the development of femoral head deformity following ischemic osteonecrosis by inhibiting osteoclast-mediated bone resorption. " 09/01/2012 - "The rationale for using bisphosphonate (BP) therapy for Legg-Calvé-Perthes disease (LCPD) is the potential to prevent substantial femoral head deformity during the fragmentation phase by inhibiting osteoclastic bone resorption. " 01/01/2007 - "Bisphosphonate therapy has gained significant attention for the treatment of ischemic osteonecrosis of the femoral head (IOFH) because of its ability to inhibit osteoclastic bone resorption, which has been shown to contribute to the pathogenesis of femoral head deformity. "
2.	GadoliniumIBA 10/01/2018 - "In this study, we retrospectively correlated gadolinium-enhanced subtracted (DGS) and diffusion (DWI) MRI findings to the radiographic assessment according to the Catterall and Herring et al. classifications and to the final score according to Stulberg et al.: the aim was to identify a precocious, simple, and objective criterion to differentiate between forms evolving favourably and forms requiring an early surgical treatment in order to avoid femoral head deformity and subsequent osteoarthritis. "
3.	Contrast MediaIBA 05/01/2016 - "Diffusion and contrast agent-enhanced magnetic resonance (MR) imaging studies were performed in 46 children (37 boys and nine girls; mean age, 7.5 years [age range, 3.3-11.9 years]) with unilateral LCPD at the early stage before development of extensive femoral head deformity. "
4.	Biological FactorsIBA 09/01/2011 - "These studies reveal that mechanical and biological factors contribute to the development of the femoral head deformity. "
5.	Ibandronic Acid (Boniva)FDA Link 05/18/2011 - "A combination of ibandronate and BMP-2 decreased femoral head deformity while stimulating bone formation in an immature animal model of ischemic osteonecrosis." 01/01/2007 - "Intraosseous administration effectively delivered and distributed ibandronate in the infarcted femoral heads and decreased the femoral head deformity in a large animal model of Legg-Calve-Perthes disease. " 03/01/2005 - "Ibandronate preserves the trabecular structure of the osseous epiphysis and prevents femoral head deformity during the early phase of repair of ischemic necrosis in the piglet model." 03/01/2005 - "Ibandronate for prevention of femoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs." 05/18/2011 - "Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head: a combined therapy that stimulates bone formation and decreases femoral head deformity."
6.	Zoledronic Acid (Zometa)FDA Link 10/01/2013 - "A combination of NELL-1 and zoledronate can decrease the femoral head deformity while stimulating bone formation in a traumatic rat osteonecrois model, showing a potential to reverse the osteonecrosis." 08/01/2012 - "Zoledronate can decrease the femoral head deformity by reducing the osteoclast activity while suppressing new bone and vessels formation in a rat model of traumatic osteonecrosis, and therefore may delay the collapse of femoral head."
7.	FHDIBA 01/28/2022 - "The radiographical indices measured included the migration percentage (MP), sharp angle, acetabular index, centre-edge angle, neck shaft angle, head shaft angle, pelvic obliquity, femoral head sphericity, femoral head deformity (FHD) and growth plate orientation. " 12/01/2006 - "Legg-Calvé-Perthes disease (LCPD) is a juvenile form of osteonecrosis of the femoral head that can produce permanent femoral head deformity (FHD) and premature osteoarthritis. "
8.	Bone Density Conservation AgentsIBA 09/01/2011 - "The observation that the pathogenesis of femoral head deformity in Legg-Calve-Perthes disease (LCPD) relates to bone resorption without subsequent coupled bone formation leads quickly to the hypothesis that antiresorptive agents may provide a useful adjunctive avenue for therapy. "
9.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/01/2017 - "Bone morphogenetic protein (BMP)-2 and ibandronate (IB) decrease the femoral head deformity following ischemic osteonecrosis of the femoral head (ONFH). "
10.	Fluconazole (Zonal)FDA LinkGeneric 09/01/2012 - "We therefore determined (1) whether focal or generalized acetabular growth stimulation or retardation occurred based on CT analysis in combination with plain radiographic assessment; and (2) whether radiographically assessed femoral head deformity, subluxation, and acetabular dysplasia were associated with residual zonal rim dysplasia of the acetabulum. "

Therapies and Procedures

1.	Osteotomy 12/01/2016 - "According to the results of the present study, proximal femoral varus osteotomy gives good results in children between the ages of 6 and 10 years without any femoral head deformity and flattening, especially with good containment in abduction. " 12/01/2018 - "The aims of this study were to review the surgical technique for a combined femoral head reduction osteotomy (FHRO) and periacetabular osteotomy (PAO), and to report the short-term clinical and radiological results of a combined FHRO/PAO for the treatment of selected severe femoral head deformities. " 01/01/2021 - "Once exclusion criteria were applied, 15 hips were excluded due to prior hip surgery or prior femoral osteotomy, and 12 hips were excluded due to femoral head deformity. " 05/01/2020 - "Previous retrospectively collected data from a single center have suggested that early proximal femoral varus osteotomy (PFO) may shorten the length of fragmentation and allow 34% of patients to bypass fragmentation altogether resulting in less femoral head deformity. " 12/01/2018 - "Concurrent femoral head reduction and periacetabular osteotomies for the treatment of severe femoral head deformities."
2.	Therapeutics 09/01/2012 - "Clinical evidence lacks consistent patient groups and drug protocols to draw definitive conclusions that BP therapy can decrease femoral head deformity in juvenile osteonecrotic conditions. " 09/01/2012 - "However, it is unclear whether BP therapy decreases femoral head deformity. " 05/18/2011 - "A combined therapy that stimulates bone formation and decreases femoral head deformity"." 06/01/1982 - "Abduction brace therapy is continued in patients with a risk of femoral head deformity until reossification of the necrotic femoral head begins. " 09/01/2012 - "Only one study initiated BP therapy during the precollapsed stage of osteonecrosis and reported prevention of femoral head deformity in nine of 17 patients. "
3.	Acetabuloplasty 07/01/1980 - "In this review of 152 acetabuloplasties, four factors were found to adversely influence the effects of the operation: age of nine years or older, subluxation or dislocation of the femoral head, deformity of the femoral head, and restricted range of hip motion. " 03/01/1997 - "We studied six patients with severe femoral head deformity treated surgically by valgus-flexion-internal-rotation femoral osteotomy plus simultaneous acetabuloplasty based on the concept of "functional retroversion" and "functional coxa vara" of the deformed femoral head in late severe Legg-Calvé-Perthes disease and epiphyseal dysplasia. "
4.	Replacement Arthroplasty 05/01/2003 - "All 165 femoral heads removed at joint replacement surgery were divided into 4 groups according to radiographic features of hip (osteophytes, subchondral sclerosis, cysts and femoral head deformity). "
5.	Bone Transplantation (Bone Grafting) 04/01/1999 - "Excisional biopsy and curettage of the lesion followed by bone grafting resulted in healing of the acetabular lesion without acetabular dysplasia, but with a resultant coxa magna."