Solute Carrier Proteins

A large diverse group of membrane transport proteins whose families are generally classified according to function. Most SLCs localize to the CELL MEMBRANE; however, some families such as SLC25, localize to MITOCHONDRIAL MEMBRANES or other ORGANELLES.

Also Known As:

Networked: 34 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Superti-Furga, Giulio: 2 articles (01/2021 - 09/2014)
2.	Suda, Kojiro: 2 articles (06/2020 - 01/2018)
3.	Ueoka, Ibuki: 2 articles (06/2020 - 01/2018)
4.	Yamaguchi, Masamitsu: 2 articles (06/2020 - 01/2018)
5.	Yoshida, Hideki: 2 articles (06/2020 - 01/2018)
6.	Marin, Jose J G: 2 articles (01/2020 - 04/2019)
7.	Liu, Lu Ming: 2 articles (01/2019 - 01/2018)
8.	Meng, Zhi Qiang: 2 articles (01/2019 - 01/2018)
9.	Xie, Jing: 2 articles (01/2019 - 01/2018)
10.	Zhu, Xiao Yan: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Rupture 01/01/2022 - "In the present study, we found that the expression of key ferroptosis regulatory proteins, solute carrier family 7 member 11 (SLC7A11), ferroptosis suppressor protein 1 (FSP1) and glutathione peroxidase 4 (GPX4) were downregulated in aortas of Stanford type A AD (TAAD) patients, and liproxstatin-1, a specific inhibitor of ferroptosis, obviously abolished the β-aminopropionitrile (BAPN)-induced development and rupture of AD in mice. "
2.	Digestive System Neoplasms (Cancer of the Digestive System) 01/01/2018 - "In addition, small molecule modulators that pharmacologically regulate the functions of SLC proteins were discussed for their possible application in the treatment of digestive system neoplasms. " 01/01/2018 - "In this review, we critically summarized the recent advances in understanding the role of SLC proteins in digestive system neoplasms. " 01/01/2018 - "Given the important role of SLC proteins in maintaining normal functions of digestive system, dysregulation of these protein in digestive system neoplasms may deliver biological and clinical significance that deserves systemic studies. "
3.	Adenocarcinoma 01/01/2019 - "The aim of this study was to identify the function of the Mg2+ transporter protein solute carrier family 41 member 1 SLC41A1 in pancreatic ductal adenocarcinoma and the underlying mechanisms. " 01/01/2019 - "A total of 27 solute carrier proteins were differentially expressed in pancreatic ductal adenocarcinoma. " 01/01/2019 - "Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis."
4.	Neoplasms (Cancer) 02/14/2023 - "It is known that altered expression and function of solute carrier proteins from the SLC6 family could be associated with severe diseases, including cancers. " 01/01/2023 - "Solute carrier (SLC) proteins play an important role in tumor metabolism. " 01/01/2022 - "SLC25A1, the gene encoding mitochondrial carrier subfamily of solute carrier proteins, was reported to be overexpressed in certain solid tumors. " 01/01/2021 - "With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions." 01/01/2020 - "Solute carrier proteins and c-Myc: a strong connection in cancer progression."
5.	Citrullinemia 01/01/2002 - "By using homozygosity mapping and positional cloning, we have shown that adult-onset type II citrullinemia (CTLN2) is caused by mutations of the SLC25A13 gene, which is localized on chromosome 7q21.3 and encodes a mitochondrial solute carrier protein named citrin. " 01/01/2001 - "Pathogenesis of adult-onset type II citrullinemia caused by deficiency of citrin, a mitochondrial solute carrier protein: tissue and subcellular localization of citrin." 12/01/2002 - "Adult-onset type II citrullinemia (CTLN2), characterized by a liver-specific deficiency of urea cycle enzyme, argininosuccinate synthetase, is caused by mutations in SLC25A13 that encodes a calcium binding mitochondrial solute carrier protein, citrin. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Aminopropionitrile
3.	Phospholipid Hydroperoxide Glutathione Peroxidase
4.	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)
5.	liproxstatin-1
6.	citrin
7.	Enzymes
8.	Carrier Proteins (Binding Protein)
9.	Adenosine Triphosphate (ATP)
10.	sepantronium