Tripartite Motif Proteins

A protein family defined by the presence of three ZINC FINGER domains, one of which is a RING FINGER DOMAIN, a coiled-coil region, and a highly variable C-terminal region. They function in many cellular processes including APOPTOSIS and CELL CYCLE regulation.

Also Known As:

RBCC Protein Family; RBCC Proteins; TRIM Protein Family; TRIM Proteins; Family, RBCC Protein; Family, TRIM Protein; Motif Protein, Tripartite; Motif Proteins, Tripartite; Protein Family, RBCC; Protein Family, TRIM; Protein, RBCC; Protein, TRIM; Protein, Tripartite Motif; Proteins, RBCC; Proteins, TRIM; Proteins, Tripartite Motif; RBCC Protein; TRIM Protein; Tripartite Motif Protein

Networked: 268 relevant articles (4 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Tripartite Motif Proteins: 268

Experts

1.	Hatakeyama, Shigetsugu: 6 articles (02/2017 - 07/2008)
2.	Sodroski, Joseph: 5 articles (07/2013 - 12/2005)
3.	Song, Byeongwoon: 5 articles (07/2013 - 12/2005)
4.	Cheung, Belamy B: 4 articles (05/2016 - 02/2012)
5.	Marshall, Glenn M: 4 articles (05/2016 - 02/2012)
6.	Ma, Jianjie: 3 articles (09/2021 - 11/2019)
7.	Tan, Tao: 3 articles (09/2021 - 11/2019)
8.	Yang, Bo: 3 articles (09/2021 - 06/2015)
9.	Sunnerhagen, Maria: 3 articles (01/2019 - 02/2006)
10.	Wahren-Herlenius, Marie: 3 articles (01/2019 - 02/2006)

Related Diseases

1.	Traumatic Brain Injuries (Traumatic Brain Injury) 09/30/2021 - "Correction to: The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury." 11/28/2019 - "The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury."
2.	Neoplasms (Cancer) 01/01/2023 - "Several studies have discovered that TRIM58, a member of tripartite motif protein family, shows antitumor effect in multiple types of cancer. " 10/13/2020 - "A growing number of studies has highlighted the critical impact of members of the tripartite motif (TRIM) protein family on most types of human malignancies including CRC. " 11/09/2018 - "BACKGROUND Recent studies have shown that some members of the tripartite motif-containing protein (TRIM) family function as important regulators in several tumors. " 08/11/2023 - "Accumulating data have revealed the pivotal function of tripartite motif protein 38 (TRIM38) in tumors. " 08/01/2023 - "Initially, the function research of TRIM proteins mainly focused on cancer. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2022 - "Understanding the different pathways these TRIM proteins employ during episodes of neurodegenerative disorder represents a promising therapeutic target. " 01/01/2022 - "Emerging evidence has shown that TRIM proteins are key players in facilitating the clearance of misfolded protein aggregates associated with neurodegenerative disorders. "
4.	Infections 01/01/2023 - "In this study, we investigated the role TRIM proteins whose expression is modulated in response to Mtb or BCG infection of primary macrophages. " 06/30/2023 - "We recently reported that tripartite motif protein 25 (TRIM25), an important ISG, was highly upregulated in duck embryo hepatocyte cells (DEFs) after infection with duck viral hepatitis A virus type 1 (DHAV-1). " 10/01/2019 - "However, the transduction of simian cells with human immunodeficiency virus type 1 (HIV-1)-derived vectors is inefficient due to capsid-specific restriction factors, such as the tripartite motif-containing protein tripartite motif 5α, which prevent infection with non-host-adapted retroviruses. " 01/01/2018 - "A tripartite motif (TRIM) protein encoding gene TRIM69 is induced by dengue virus (DENV) infection as an ISG. " 01/05/2014 - "In support of this hypothesis, we showed that some human tripartite motif proteins bind the HIV-1 capsid but do not restrict HIV-1 infection, such as human TRIM6 and TRIM34. "
5.	Carcinogenesis 05/01/2022 - "However, the exact mechanisms of TRIM proteins in IBD pathogenesis and IBD-related carcinogenesis are still unknown, and more studies are warranted to explore potential therapeutic targets of TRIM proteins in IBD." 01/01/2017 - "Recent studies have shown that some members of the tripartite motif-containing protein (TRIM) family serve as important regulators of tumorigenesis. " 11/01/2012 - "Recent studies have shown that some members of the tripartite motif-containing protein (TRIM) family, which is characterized by a conserved RING finger, B-box, and coiled-coil domains, function as important regulators for carcinogenesis. " 12/02/2022 - "The tripartite motif (TRIM) proteins function as important regulators in innate immunity, tumorigenesis, cell differentiation and ontogenetic development. " 03/01/2021 - "TRIM proteins play key roles in many biological processes, including innate immunity, tumorigenesis, cell differentiation and ontogenetic development. "

Related Drugs and Biologics

1.	Protein Aggregates
2.	Hormones (Hormone)
3.	Proteins (Proteins, Gene)
4.	Ubiquitin
5.	Ligases (Synthetase)
6.	Antiviral Agents (Antivirals)
7.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
8.	Interferons
9.	Inflammasomes
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)