Perilipins

A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.

Also Known As:

PAT Proteins; PLIN Proteins; Perilipin Proteins; Perilipin-Adipophilin-TIP47 Proteins; Perilipin Adipophilin TIP47 Proteins; Proteins, PAT; Proteins, PLIN; Proteins, Perilipin; Proteins, Perilipin-Adipophilin-TIP47

Networked: 31 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Lipid Droplet Associated Proteins: 28
      - Perilipins: 31
        Perilipin-2: 221
        Perilipin-1: 193
        Perilipin-5: 34
        Perilipin-3: 23
        Perilipin-4: 4

Experts

1.	Li, Feng: 2 articles (01/2020 - 05/2018)
2.	Liu, Chunxia: 2 articles (01/2020 - 05/2018)
3.	Meng, Lian: 2 articles (01/2020 - 05/2018)
4.	Zhang, Pengpeng: 2 articles (01/2020 - 05/2018)
5.	Schirmacher, Peter: 2 articles (01/2019 - 03/2010)
6.	Straub, Beate K: 2 articles (01/2019 - 03/2010)
7.	Ertl, R: 1 article (12/2022)
8.	Fuchs-Baumgartinger, A: 1 article (12/2022)
9.	Gabner, S: 1 article (12/2022)
10.	Hlavatý, J: 1 article (12/2022)

Related Diseases

1.	Liposarcoma 01/01/2020 - "This study aims to assess perilipins expression in subtypes of liposarcoma and various non-lipomatous sarcomas. " 01/01/2020 - "Methods: A large set of 245 soft tissue sarcoma paraffin-embedded samples including 66 liposarcomas and 179 non-lipomatous sarcomas were collected for tissue microarray and immunohistochemistry to assess perilipins expression. " 02/01/2017 - "The present study focuses on the expression and possible diagnostic impact of two PAT family proteins, perilipin 1/perilipin and perilipin 2/adipophilin in human liposarcomas. "
2.	Neoplasms (Cancer) 01/01/2019 - "The aim of this study was to investigate the expression of perilipins in 478 human soft tissue tumors and 60 respective normal tissues. " 01/01/2019 - "So far, the use of perilipins as markers for differential diagnosis of soft tissue tumors has only been studied in a few cases. " 05/01/2018 - "Roles of Perilipins in Diseases and Cancers." 08/07/2023 - "Challenges in Pharmacological Intervention in Perilipins (PLINs) to Modulate Lipid Droplet Dynamics in Obesity and Cancer." 05/01/2018 - "Available data on the pathophysiology of perilipins and the relationship of perilipins with endocrine metabolic diseases and cancers are summarized in this mini-review. "
3.	Insulin Resistance 10/01/2009 - "This study aimed to explore the role of the PAT proteins OXPAT and ADRP in skeletal muscle lipid metabolism and their putative role in modulating insulin sensitivity. " 08/01/2008 - "Our hypothesis is that PAT proteins modulate LD metabolism and therefore insulin resistance. " 08/01/2008 - "Downregulation of PAT proteins also produced insulin resistance, as indicated by decreased insulin stimulation of Akt phosphorylation (P < 0.001). " 08/01/2008 - "These data establish an important role for PAT proteins as surfactant at the LD surface, packaging lipids in smaller units and restricting access of lipases and thus preventing insulin resistance. " 02/01/2012 - "We observed that all perilipins were expressed in skeletal muscle biopsies with the highest mRNA levels of perilipin 2, 4 and 5. Cultured myotubes predominantly expressed perilipin 2 and 3. In vitro, incubation of myotubes with fatty acids enhanced mRNA expression of perilipin 1, 2 and 4. In vivo, low fat diet increased mRNA levels of perilipin 3 and 4. Endurance training, but not strength training, enhanced the expression of perilipin 2 and 3. Perilipin 1 mRNA correlated positively with body fat mass, whereas none of the perilipins were associated with insulin sensitivity. "
4.	Weight Loss (Weight Reduction) 09/11/2022 - "Perilipins are involved in fat storage in skeletal muscles and their upregulation, along with the analysis of circulatory lipid profiles reported in the present study, suggest important adaptations induced by the two types of training protocols that favour fat consumption and weight loss in obese subjects."
5.	Osteosarcoma (Osteogenic Sarcoma) 12/01/2022 - "Lipid droplets and perilipins in canine osteosarcoma. " 12/01/2022 - "With emphasis on lipid droplet-coating proteins (perilipins, PLINs), this study intended to shed light on the presence and formation of lipid droplets in canine osteosarcoma. "

Related Drugs and Biologics

1.	Lipids
2.	Proteins (Proteins, Gene)
3.	Perilipin-1
4.	Perilipin-2
5.	Methionine (L-Methionine)
6.	Choline (Choline Chloride)
7.	Triglycerides (Triacylglycerol)
8.	Insulin (Novolin)
9.	Fatty Acids (Saturated Fatty Acids)
10.	Diacylglycerol O-Acyltransferase

Related Therapies and Procedures

1.	Endurance Training
2.	Resistance Training
3.	Fat-Restricted Diet (Diet, Fat Restricted)