Unilateral Breast Neoplasms

Tumors or cancer found specifically in one human BREAST, but not in both.

Also Known As:

Left Sided Breast Cancer; Left Sided Breast Neoplasm; Left Sided Breast Neoplasms; Left-Sided Breast Cancer; Left-Sided Breast Neoplasms; Right Sided Breast Cancer; Right Sided Breast Neoplasm; Right-Sided Breast Cancer; Right-Sided Breast Neoplasms; Unilateral Breast Cancer; Breast Cancer, Left-Sided; Breast Cancer, Right-Sided; Breast Cancer, Unilateral; Breast Cancers, Left-Sided; Breast Cancers, Right-Sided; Breast Cancers, Unilateral; Breast Neoplasm, Left-Sided; Breast Neoplasm, Right-Sided; Breast Neoplasm, Unilateral; Breast Neoplasms, Left-Sided; Breast Neoplasms, Right-Sided; Breast Neoplasms, Unilateral; Left-Sided Breast Cancers; Left-Sided Breast Neoplasm; Right Sided Breast Neoplasms; Right-Sided Breast Cancers; Right-Sided Breast Neoplasm; Unilateral Breast Cancers

Networked: 695 relevant articles (19 outcomes, 143 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Breast Neoplasms (Breast Cancer)
2.	Neoplasms (Cancer)
3.	Nocturia
4.	Polyuria
5.	Asthenia

Experts

1.	Kellokumpu-Lehtinen, Pirkko-Liisa: 10 articles (05/2022 - 03/2015)
2.	Skyttä, Tanja: 8 articles (08/2019 - 03/2015)
3.	Raatikainen, Pekka: 7 articles (05/2022 - 03/2015)
4.	Virtanen, Vesa: 7 articles (05/2022 - 03/2015)
5.	Momoh, Adeyiza O: 7 articles (01/2019 - 03/2015)
6.	Yu, Xiaoli: 6 articles (05/2017 - 08/2003)
7.	Chang, Jee Suk: 5 articles (09/2022 - 12/2013)
8.	Belka, Claus: 5 articles (08/2021 - 01/2018)
9.	Corradini, Stefanie: 5 articles (08/2021 - 01/2018)
10.	Eidemüller, Markus: 5 articles (08/2021 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Unilateral Breast Neoplasms:

1.	Analgesics (Analgesic Drugs)IBA 10/01/2021 - "In this study, we compared the analgesic efficacy of ultrasound (US)-guided rhomboid intercostal nerve block, erector spinae plane (ESP) block and serratus plane block (SAB) after modified radical mastectomy (MRM) of unilateral breast cancer. "
2.	Tamoxifen FDA LinkGeneric 07/01/2015 - "In conclusion, tamoxifen significantly reduces the incidence of CBC among BRCA1/2 mutation carriers with primary unilateral breast cancer. " 02/01/2004 - "A forty-three year old female patient with right sided breast cancer was treated with adjuvant radiotherapy and Tamoxifen. " 02/02/2000 - "To examine the effect of tamoxifen therapy, bilateral prophylactic oophorectomy (PO), prophylactic contralateral mastectomy (PCM), and combinations of these strategies on life expectancy for women with unilateral breast cancer and a BRCA1 or BRCA2 gene mutation. " 02/01/2014 - "The patient's medical history included chronic hepatitis C secondary to intravenous drug use, a history of deep venous thrombosis 25 years prior to her presentation, and a history of right-sided breast cancer 20 years prior to that was treated with lumpectomy, radiation therapy, chemotherapy, and tamoxifen (discontinued by the patient after 3 years). " 02/01/2007 - "Results were analysed from 206 evaluable patients from the IES, in which postmenopausal women with histologically confirmed and completely resected unilateral breast cancer (that was oestrogen-receptor positive or of unknown status), who were disease-free after 2-3 years of treatment with tamoxifen were randomised to continue oral tamoxifen 20 mg/day or switch to oral exemestane 25 mg/day to complete a total of 5 years of adjuvant endocrine therapy. "
3.	Phenobarbital (Luminal)FDA Link 12/29/2022 - "Most patients with luminal stage I/II unilateral breast cancer benefited from bilateral risk-reducing mastectomy and risk-reducing salpingo-oophorectomy. " 01/01/2022 - "Two hundred and fifty nine patients with unilateral breast cancer, including 73 (28.2%) HER2+, 112 (43.2%) luminal, and 74 (28.6%) triple negative breast cancers (TNBC), were included. " 01/01/2023 - "We analyzed 42 unilateral breast cancer samples, with 18 classified as luminal A, 10 as luminal B, 8 as Human epidermal growth factor receptor 2 (HER2)-positive, and 6 as basal-like using PAM50. "
4.	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/01/1995 - "Ten years after being diagnosed with a unilateral breast cancer, the patient presented with asthenia, thirst, polyuria and nocturia improved by subcutaneous DDAVP. "
5.	exemestane (Aromasin)FDA Link 02/01/2007 - "Results were analysed from 206 evaluable patients from the IES, in which postmenopausal women with histologically confirmed and completely resected unilateral breast cancer (that was oestrogen-receptor positive or of unknown status), who were disease-free after 2-3 years of treatment with tamoxifen were randomised to continue oral tamoxifen 20 mg/day or switch to oral exemestane 25 mg/day to complete a total of 5 years of adjuvant endocrine therapy. "
6.	Protons (Proton)IBA 01/01/2021 - "Both proton and VMAT in combination with CPAP can minimize the radiation exposure to heart and lung with optimal target coverage in regional RT for left-sided breast cancer. " 07/01/2015 - "Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided breast cancer." 01/01/2021 - "Proton versus Photon Breath-Hold Radiation for Left-Sided Breast Cancer after Breast-Conserving Surgery: A Dosimetric Comparison." 11/01/2002 - "Protons appear to have major advantages in terms of lower complication risks when compared with treatments using conventional radiation qualities for treating node-positive left-sided breast cancer after breast-conserving surgery." 01/01/2021 - "The aim of this study was to evaluate the clinical impact of relative biological effectiveness (RBE) variations in proton beam scanning treatment (PBS) for left-sided breast cancer versus the assumption of a fixed RBE of 1.1, particularly in the context of comparisons with photon-based three-dimensional conformal radiotherapy (3DCRT) and volumetric modulated arc therapy (VMAT). "
7.	Hormones (Hormone)IBA 07/01/2019 - " retrospective study included 249 premenopausal women (median age, 45 years) who were diagnosed with unilateral breast cancer and underwent FDG positron emission tomography/computed tomography and hormone tests. " 05/01/2021 - "Cosmesis & QOL had been assessed in all biopsy-proven adult patients of unilateral breast cancer, who had undergone BCT with minimum three months post-BCT & three months post last adjuvant chemotherapy cycle, whichever is delivered last (with just hormonal therapy or followup remaining based on hormone receptor status). " 05/01/2013 - "Since endogenous hormone plays an important role in the development of breast cancer, it would be interesting to investigate whether the functional asymmetry of response in some patients is associated with the risk of developing unilateral breast cancer." 12/01/1989 - "To assess the relationship between hormone receptor content, mammographic tumor morphology, and breast parenchymal patterns, we reviewed charts and mammograms of 210 patients with primary unilateral breast cancer. " 01/01/2012 - "From the population-based, case-control, Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study, we included 511 women with CBC (cases) and 999 women with unilateral breast cancer (controls) who had never used postmenopausal hormone therapy. "
8.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/01/2017 - "She subsequently developed recurrent right-sided breast cancer that was treated with right mastectomy and six cycles of cyclophosphamide-docetaxel chemotherapy. " 07/01/1996 - "The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) every three weeks, or no further treatment. " 08/28/2017 - "She had been treated for stage IIIc left-sided breast cancer 2 years ago with six cycles of chemotherapy with docetaxel, adriamycin, and cyclophosphamide after undergoing modified radical mastectomy. " 07/01/1997 - "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity. " 01/01/1983 - "21 unilateral breast cancer patients taking different combinations of chemotherapeutic agents (cyclophosphamide, methotrexate, 6-fluorouracil, vincristine, and prednisone) were studied to determine how chemotherapy affected their granulocytes. "
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/2023 - "Strikingly, patients treated for right-sided breast cancers also showed increased hepatocyte and liver endothelial DNA in the circulation, indicating the impact on liver tissues. " 06/01/2002 - "Deoxyribonucleic acid samples from 29 Arab women and 11 Asian women, with unilateral breast cancer were investigated for BRCA1 and BRCA2 mutations. " 04/01/2012 - "We selected participants recruited to the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study and screened lymphocyte DNA from cases with contralateral breast cancer (n = 559) and matched controls with unilateral breast cancer (n = 565) for PALB2 mutations. " 12/10/2018 - "Germline DNA from 1514 CBC cases and 2203 unilateral breast cancer controls was genotyped for seven single nucleotide polymorphisms, one three-nucleotide insertion-deletion, and a full gene deletion. "
10.	Brain Natriuretic Peptide (Natrecor)FDA Link 02/01/2016 - "Our study evaluated brain natriuretic peptide (BNP) changes over time after adjuvant radiotherapy (RT) in women with left-sided breast cancer investigating its correlation with heart dosimetric parameters. " 02/01/2016 - "Brain natriuretic peptide as a cardiac marker of transient radiotherapy-related damage in left-sided breast cancer patients: A prospective study." 01/01/2015 - "To analyze temporal changes of B-type natriuretic peptide (BNP) used as index of heart remodeling in left-sided breast cancer patients after radiotherapy (RT) and its relationship with dosimetric parameters. " 01/01/2015 - "Kinetics of B-type natriuretic peptide plasma levels in patients with left-sided breast cancer treated with radiation therapy: Results after one-year follow-up." 02/01/2012 - "N-terminal pro-B-type natriuretic peptide plasma levels as a potential biomarker for cardiac damage after radiotherapy in patients with left-sided breast cancer."

Therapies and Procedures

1.	Prophylactic Mastectomy 03/01/2018 - "The proportion of women with unilateral breast cancer and no familial or genetic risk factors who elect contralateral prophylactic mastectomy (CPM) has grown dramatically, even in the absence of clear data demonstrating improved outcomes. " 01/01/2005 - "Contralateral prophylactic mastectomy (CPM) is the removal of a nonaffected breast in a woman with unilateral breast cancer and is effective in reducing the risk of recurrences. " 11/01/2021 - "Women with early-stage unilateral breast cancer and no familial or genetic risk factors are increasingly electing contralateral prophylactic mastectomy (CPM), despite the lack of evidence demonstrating improved outcomes. " 10/01/2021 - "Psychosocial outcomes are not improved with contralateral prophylactic mastectomy in women with unilateral breast cancer. " 10/01/2023 - "In this study, we compared complication rates of unilateral breast cancer patients undergoing contralateral prophylactic mastectomy (BM-TP) to patients undergoing bilateral prophylactic mastectomy (BM-P). "
2.	Radiotherapy 03/01/2021 - "DIBH leads to significant reduction in OAR doses and is suggested for all patients of left-sided breast cancer undergoing radiotherapy. " 11/19/2021 - "Compared to coVMAT, ncVMAT provides improved conformity and homogeneity of whole P TV, better dose sparing of the heart, bilateral lungs, left anterior descending coronary artery (LAD), and right breast for locoregional radiotherapy of left-sided breast cancer with IMN, potentially reducing the risk of normal tissue damage." 05/01/2015 - "The purpose of this study was to evaluate the efficacy of voluntary deep inspiration breath-hold (DIBH) over a free-breathing (FB) technique to minimize cardiac radiation exposure in radiation therapy of left-sided breast cancer. " 01/01/2023 - "The Efficacy of Multi-Leaf Collimator in the Reduction of Cardiac and Coronary Artery Dose in Left-Sided Breast Cancer Radiotherapy." 02/22/2023 - "The primary aim of the BRAVEHeart (Breast Radiotherapy Audio Visual Enhancement for sparing the Heart) trial is to assess the accuracy and usability of a novel device, Breathe Well, for DIBH guidance for left-sided breast cancer patients. "
3.	Mastectomy (Mammectomy) 02/01/2015 - "Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: a prospective analysis." 09/25/2023 - "The study included 15 studies (13 quantitative, 1 qualitative, and 1 mixed-methods) evaluating outcomes for at least 1954 women who underwent a bilateral mastectomy without reconstruction (BM) after unilateral breast cancer. " 09/25/2023 - "PubMed, MEDLINE, CINAHL and PsycINFO were searched to identify primary research studies, published in English between 1 January 2000 and 30 August 2022, evaluating clinical or patient-reported outcomes for women who underwent a CM without reconstruction after a mastectomy for unilateral breast cancer. " 10/21/2022 - "Eight left-sided and eight right-sided breast cancer patients who underwent IBR after mastectomy were included in this study. " 03/01/2022 - "Material and methods Thirty-five left-sided breast cancer patients' post-mastectomy were included in this study, and three different plans for adjuvant radiation were created using 3D-CRT, IMRT, and VMAT. "
4.	Therapeutics 07/01/2010 - "Of 739 consecutive patients living in the city of Nijmegen, the Netherlands, 477 patients with primary unilateral breast cancer were not treated with adjuvant systemic therapy and eligible for the study. " 07/01/2022 - "We conducted a retrospective cohort study among women with stage I-III, HR-positive unilateral breast cancer diagnosed at Columbia University Medical Center from 2007 to 2017, who received adjuvant endocrine therapy and had at least two mammograms (baseline, annual follow-up) of the contralateral unaffected breast for CNN analysis. " 09/01/2016 - "Deep inspiration breath hold with electromagnetic confirmation of chest wall position for adjuvant therapy of left-sided breast cancer: Technique and accuracy." 02/15/2002 - "We compared incidence of MI in the study cohort with the general population and incidence of MI after therapy for left- versus right-sided breast cancer. " 12/15/1982 - "[Heart function during postoperative high-voltage therapy in female patients with left-sided breast cancer]."
5.	Modified Radical Mastectomy (Mastectomy, Modified) 01/01/1996 - "The present study consists of 1,238 women with unilateral breast cancer treated with modified radical mastectomy living in the geographic area of Haukeland Hospital. " 01/14/2022 - "Our analyses suggested VMAT as a preferred option in left-sided breast cancer patients treated with modified radical mastectomy." 01/14/2022 - " study aimed to clarify whether VMAT is superior to intensity-modulated radiotherapy (IMRT) in treatment planning for left-sided breast cancer patients after modified radical mastectomy.Left" 05/01/2021 - "Our study aimed to improve the dosimetry of post modified radical mastectomy intensity-modulated radiotherapy (PMRM-IMRT) for left-sided breast cancer patients by tailoring and minimizing PTV expansion three-dimensionally utilizing 4D CT combined with on-board cone beam CT (CBCT). " 09/01/2023 - "Serratus anterior combined with transverse thoracic muscle plane block may be a safer, easier, and equally effective nerve block strategy than paravertebral block in patients undergoing modified radical mastectomy for unilateral breast cancer."