Intratympanic Injection

The administration of liquid substances into the TYMPANIC CAVITY with a hypodermic syringe.

Also Known As:

Injection, Intratympanic; Transtympanic Administration; Administration, Transtympanic; Administrations, Transtympanic; Injections, Intratympanic; Intratympanic Injections; Transtympanic Administrations

Networked: 179 relevant articles (28 outcomes, 26 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Drug Administration Routes: 28
    - Injections: 43809
      - Intratympanic Injection: 179

Experts

1.	Nakashima, Tsutomu: 10 articles (01/2012 - 01/2008)
2.	Naganawa, Shinji: 9 articles (02/2011 - 01/2008)
3.	Sone, Michihiko: 8 articles (02/2011 - 01/2008)
4.	Saliba, Issam: 5 articles (04/2013 - 06/2010)
5.	Zhang, Ru: 4 articles (03/2020 - 02/2007)
6.	Fukuoka, Hisakuni: 4 articles (01/2018 - 11/2009)
7.	Tsukada, Keita: 4 articles (01/2018 - 11/2009)
8.	LeBel, Carl: 4 articles (12/2016 - 03/2014)
9.	Iwano, Shingo: 4 articles (01/2010 - 01/2008)
10.	Dai, Chunfu: 3 articles (03/2020 - 02/2007)

Related Diseases

1.	Meniere Disease (Menieres Disease) 01/01/2019 - "Only randomised controlled trials that compared the effectiveness of medications used for intratympanic injection to treat Ménière's disease with each other or a placebo were included. " 01/01/2019 - "All medications are more effective than a placebo in the treatment of Ménière's disease by intratympanic injection. " 01/01/2019 - "To assess the effectiveness and safety of the different medications used in the treatment of Ménière's disease by intratympanic injection using a network meta-analysis. " 01/01/2019 - "Different medications for the treatment of Ménière's disease by intratympanic injection: A systematic review and network meta-analysis." 09/01/2012 - "A randomized, double-blind, placebo-controlled clinical study to assess safety and clinical activity of OTO-104 given as a single intratympanic injection in patients with unilateral Ménière's disease."
2.	Vertigo (Positional Vertigo) 01/01/2022 - "To assess the accuracy of the VOR gain reduction after horizontal canal stimulation, as measured with the video head-impulse test (vHIT) 1 month after the first intratympanic injection, in predicting the need for one or more instillations to control vertigo spells in the long term. " 12/01/2016 - "The number of DA and status of vertigo control after intratympanic injection were evaluated. " 01/01/2015 - "The vertigo intensity, vertigo frequency, vertigo duration and the functional level scale after intratympanic injection was decreased significantly." 08/01/2014 - "Cases were included if auditory and vertigo control data were available before and a minimum of two years after treatment, in patients without previous otologic surgery or intratympanic injections. " 06/01/2010 - "After the modified intratympanic injections for MD patients, vertigo control was achieved in 89% patients, with hearing deterioration identified in 16% patients. "
3.	Sudden Hearing Loss (Sudden Deafness) 08/01/2005 - "A clinical trial of intratympanic injections for idiopathic sudden hearing loss was successfully completed and promising results were found." 12/01/2014 - "In a separate prospective clinical study, 79 patients with refractory sudden hearing loss underwent intratympanic injection. " 01/01/2021 - "The present study aims to investigate the clinical efficacy of the intratympanic injection of dexamethasone for treating sudden deafness. " 01/01/2018 - "The use of glucocorticoids for secondary (salvage/rescue) therapy of idiopathic sudden hearing loss (ISSHL), including controlled and uncontrolled studies with intratympanic injections or continuous, catheter mediated applications, were evaluated by means of a meta-analysis in an attempt to define optimal local drug delivery protocols for ISSHL. " 01/01/2021 - "The intratympanic injection of dexamethasone is a better choice for refractory sudden deafness due to its high efficacy and fewer adverse reactions."
4.	Tinnitus 03/01/2013 - "While different compounds have been tested for their effects on tinnitus by intratympanic injection, there has been no breakthrough so far. " 03/01/2013 - "Since the 1940s, various attempts have been made to treat peripheral tinnitus by way of intratympanic injection. " 01/01/2000 - "The results of this medical therapy were positive and ranged from complete annulment to attenuation of the tinnitus, which was confirmed by audiometric masking 30 minutes after the intratympanic injection. " 09/01/1950 - "Intratympanic injection for tinnitus aurium." 08/01/2020 - "The effect of the intratympanic injection of dexamethasone on the efficacy of treatment of tinnitus severity was statistically significant."
5.	Hearing Loss (Hearing Impairment) 10/01/2015 - "[Intratympanic injection therapy for therapy refractory acute hearing loss: A safe option for secondary treatment]." 04/01/2015 - "Systemic administration of compound A (1.5 mg/kg and 4.5 mg/kg) did not cause hearing threshold shifts, whereas the intratympanic injection (1 mM and 10 mM) resulted in a hearing loss. " 12/01/2010 - "There were no serious unexpected adverse events in the 38 patients except one aggravation of hearing loss occurred after intratympanic injection. " 06/01/2010 - "The 3-week interval titration injection technique thereby had a relatively high vertigo control rate with a low risk of hearing loss, and is a viable alternative to other intratympanic injection protocols." 12/01/2022 - "Dexamethasone sodium phosphate (Dex-SP) is the most commonly used drug administered via intratympanic injection for the treatment of acute hearing loss, but its penetration efficiency into the inner ear is very low. "

Related Drugs and Biologics

1.	Dexamethasone (Maxidex)
2.	Gentamicins (Gentamicin)
3.	Methylprednisolone
4.	Cisplatin (Platino)
5.	Steroids
6.	Prednisolone (Predate)
7.	Betamethasone (Celestone)
8.	Diuretics
9.	D-JNKI-1
10.	Glucocorticoids

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Catheters
4.	Drug Therapy (Chemotherapy)
5.	Anesthesia