Serotonin and Noradrenaline Reuptake Inhibitors

Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS.

Also Known As:

SNRIs; SSRIs and NRIs; Serotonin and Noradrenaline Uptake Inhibitors; Serotonin and Norepinephrine Reuptake Inhibitors; Serotonin and Norepinephrine Uptake Inhibitors; NRIs and SSRIs; SNRI

Networked: 706 relevant articles (108 outcomes, 154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Neurotransmitter Uptake Inhibitors: 1
        Serotonin and Noradrenaline Reuptake Inhibitors: 706
    - Membrane Transport Modulators
      - Neurotransmitter Uptake Inhibitors: 1
        Serotonin and Noradrenaline Reuptake Inhibitors: 706
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Neurotransmitter Uptake Inhibitors: 1
        Serotonin and Noradrenaline Reuptake Inhibitors: 706

Experts

1.	Thase, Michael E: 8 articles (01/2017 - 12/2007)
2.	McIntyre, Roger S: 5 articles (12/2019 - 01/2010)
3.	Baldwin, David S: 5 articles (05/2015 - 01/2006)
4.	Kaye, Alan D: 4 articles (01/2022 - 07/2019)
5.	Strawn, Jeffrey R: 4 articles (01/2021 - 02/2016)
6.	Häuser, Winfried: 4 articles (01/2018 - 01/2009)
7.	Obata, Hideaki: 4 articles (10/2017 - 09/2010)
8.	Saito, Shigeru: 4 articles (10/2017 - 09/2010)
9.	Buoli, Massimiliano: 4 articles (03/2017 - 01/2010)
10.	Arnold, Lesley M: 4 articles (07/2015 - 01/2006)

Related Diseases

1.	Pain (Aches) 01/01/2020 - "Lumbar transforaminal selective nerve root injection (SNRI) is effective for controlling radicular pain. " 01/01/2023 - "The study patients were classified as treatment‑nonresponsive if the SNRI treatment resulted in a reduction in reported pain by less than 30%. " 11/01/2023 - "Resistance to SNRI was defined as <30% pain reduction during at least 8-week treatment. " 12/01/2021 - "Treatment outcomes show that SNRI users presented higher scores on the domains of pain and physical functioning. " 07/01/2015 - "At baseline, 52.3% of patients were taking an SSRI and 47.7% an SNRI, and mean pain score was 6.7. "
2.	Anxiety Disorders (Anxiety Disorder) 01/01/2010 - "Anxiety disorders are characterized by a typically chronic course, high rates of comorbidity and frequent partial response to standard treatments, and the increasing use of SNRIs reflects currently unmet clinical need, in terms of overall response, remission rates and treatment tolerability." 02/01/2023 - "SSRI and SNRI treatment is effective for childhood anxiety disorders, with positive effect of treatment outweighing the negative effects." 01/01/2018 - "The results of this study challenge the use of SNRI as first-line treatment for mood and anxiety disorders." 01/01/2008 - "Although there was an increase in SSRI/SNRI use in older participants with anxiety disorders over the course of study, at nine years of follow-up, only 35% of participants were utilizing SSRI/SNRI medication, while more than one-half of the same participants were continuing to use BZs. " 11/01/2019 - "The guide recommends SSRI and SNRI drugs as first-line treatments for generalized anxiety disorder (GAD). "
3.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2023 - "Real-world characteristics of European patients receiving SNRIs as first-line treatment for major depressive disorder." 01/01/2022 - "Dose-Response Relationship in Selective Serotonin and Norepinephrine Reuptake Inhibitors in the Treatment of Major Depressive Disorder: A Meta-Analysis and Network Meta-Analysis of Randomized Controlled Trials." 05/24/2016 - "Only clinical trials that randomly assigned one SNRI or placebo to patients aged 7 to 18 years who met the diagnostic criteria for major depressive disorder were included. " 10/01/2022 - "It has also been considered that both SSRI and SNRI can improve the symptoms of major depressive disorder by increasing the concentration of monoamine in the synaptic cleft based on the monoamine hypothesis. " 01/01/2022 - "This meta-analysis aimed to find evidence of a dose-response relationship or to the contrary in direct comparisons of different SNRI doses in patients with major depressive disorder. "
4.	Neuralgia (Stump Neuralgia) 01/01/2022 - "SNRIs had good evidence for neuropathic pain and a more favorable safety profile than TCAs. " 01/01/2022 - "The article describes the function, role, and use of SNRIs to treat chronic and neuropathic pain by altering the noradrenergic descending inhibitory pathways." 05/02/2012 - "Serotonin and noradrenaline reuptake inhibitors have shown to produce antinociceptive effects in several animal models of neuropathic pain. " 01/01/2021 - "Novel MONRI, SNRI and cannabinoid receptor agonists have shown some promise for neuropathic pain relief in human trials, but await regulatory approvals. " 03/01/2016 - "The aim of this study was to investigate the effect of SNRI duloxetine in rat model of IVD-related neuropathic pain. "
5.	Fibromyalgia (Fibrositis) 12/01/2010 - "There is also sufficient evidence to indicate that SNRIs are effective in the treatment of fibromyalgia and may be considered early in the treatment of fibromyalgia." 09/01/2007 - "Other selective SNRIs also show promise in the treatment of fibromyalgia. " 01/01/2021 - "Placebo Responses and Their Clinical Implications in Fibromyalgia: A Meta-Analysis Using SSRI and SNRI Trials." 01/01/2018 - "We selected randomized, controlled trials of any formulation of SNRIs against placebo or any other active treatment of fibromyalgia in adults. " 11/01/2023 - "Psychological variables associated with resistance to treatment with serotonin and noradrenaline reuptake inhibitors in fibromyalgia."

Related Drugs and Biologics

1.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
2.	Serotonin (5 Hydroxytryptamine)
3.	Norepinephrine (Noradrenaline)
4.	Duloxetine Hydrochloride (Cymbalta)
5.	Milnacipran (Ixel)
6.	Antidepressive Agents (Antidepressants)
7.	Venlafaxine Hydrochloride (Effexor)
8.	Serotonin and Noradrenaline Reuptake Inhibitors
9.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
10.	Pregabalin (Lyrica)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Spinal Cord Stimulation
4.	Viscosupplementation
5.	Intra-Articular Injections