Sildenafil Citrate (Viagra)

A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.

Also Known As:

Viagra; 1-((3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate; Acetildenafil; Desmethyl Sildenafil; Desmethylsildenafil; Homosildenafil; Hydroxyhomosildenafil; NCX-911; Revatio; Sildenafil; Sildenafil Lactate; Sildenafil Nitrate; UK 92480-10; UK-92,480-10; Citrate, Sildenafil; Lactate, Sildenafil; NCX 911; NCX911; Nitrate, Sildenafil; Sildenafil, Desmethyl; UK 92,480 10; UK 92480 10; UK 9248010

Networked: 4137 relevant articles (704 outcomes, 911 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kukreja, Rakesh C: 28 articles (11/2020 - 09/2002)
2.	Seeger, Werner: 21 articles (01/2018 - 04/2002)
3.	Grimminger, Friedrich: 21 articles (11/2017 - 04/2002)
4.	Mulhall, John P: 18 articles (01/2021 - 01/2004)
5.	Das, Anindita: 18 articles (11/2020 - 02/2004)
6.	Cappelleri, Joseph C: 17 articles (04/2018 - 05/2003)
7.	Tseng, Li-Jung: 17 articles (04/2018 - 11/2005)
8.	Guazzi, Marco: 16 articles (01/2022 - 10/2004)
9.	Chopp, Michael: 15 articles (01/2019 - 11/2002)
10.	Kass, David A: 15 articles (01/2018 - 01/2005)

Related Diseases

1.	Erectile Dysfunction 08/01/2005 - "Sildenafil, a highly selective inhibitor of PDE 5, is effective in the treatment of erectile dysfunction. " 07/01/2005 - "Most of the available data on efficacy for sildenafil are based on a questionnaire and erectile dysfunction (ED) is classified with minor or severe organic factors. " 12/20/2000 - "In most patients with good sleep efficiency and who have erectile dysfunction, sildenafil, rather than a placebo, taken at bedtime produces a significantly improved nocturnal erectile activity. " 07/01/2000 - "Sildenafil is highly effective for treating erectile dysfunction (ED). " 10/01/1999 - "Sildenafil is highly effective in the treatment of erectile dysfunction. "
2.	Pulmonary Hypertension 01/01/2022 - "Oral sildenafil has proven to be effective and safe in the management of PPHN in neonates with persistent pulmonary hypertension. " 07/01/2014 - "Intravenous sildenafil treatment has recently shown promising results and good tolerability in the treatment of refractory pulmonary hypertension (PH) in term and near-term neonates, while comparable data in preterm infants are still lacking. " 01/01/2006 - "Sildenafil has beneficial effects on cerebral vascular reactivity indicative of an improvement in neurovascular coupling in patients with pulmonary hypertension. " 08/01/2009 - "Long-term use of sildenafil in patients with secondary forms of pulmonary hypertension is associated with a sustained improvement in cardio-pulmonary haemodynamics. " 08/01/2021 - "We conclude that oral sildenafil treatment is a safe, simple and effective treatment for persistent pulmonary hypertension in newborn. "
3.	Pulmonary Arterial Hypertension 05/13/2014 - "The double-blind, placebo-controlled Sildenafil in Treatment-Naive Children, Aged 1 to 17 Years, With Pulmonary Arterial Hypertension (STARTS-1) study assessed sildenafil in pediatric patients with pulmonary arterial hypertension; improved hemodynamics and exercise capacity occurred in medium- and high-dose groups. " 02/01/2008 - "After increasing the sildenafil dose to ensure therapeutic drug levels over 24 hours, the pulmonary arterial hypertension and physical performance of the patient improved significantly. " 04/20/2005 - "Sildenafil use in children appears to be safe and may be beneficial in the management of pulmonary arterial hypertension." 01/01/2012 - "Sildenafil has been demonstrated as effective for the treatment of pulmonary arterial hypertension (PAH). " 02/15/2011 - "Sildenafil has been shown to be effective in pulmonary arterial hypertension (PAH). "
4.	Hypertension (High Blood Pressure) 01/01/2011 - "It is concluded that sildenafil was a well-tolerated and highly effective treatment of ED in outpatients with diabetes and/or hypertension from the three Middle Eastern countries studied." 06/01/2005 - "Clinical studies have demonstrated that sildenafil successfully treats ED of varied organic, psychogenic or mixed aetiology, and is effective in men with ED and comorbidities such as hypertension, hyperlipidaemia, diabetes or depression. " 01/01/2016 - "Treatment with sildenafil may be beneficial in pregnancies complicated by nonsevere hypertension." 03/01/2009 - "To date, PDE5 inhibition has been shown to be effective for the treatment of idiopathic pulmonary artery hypertension, and sildenafil is approved for this indication. " 01/01/2009 - "The objective of this study was to determine the hemodynamic outcome in a consecutive cohort of patients offered sildenafil as first-line treatment for portopulmonary hypertension. "
5.	Heart Failure 11/01/2014 - "Fourteen patients were included, 8 patients in group 1 and 6 in group 2. Sildenafil was administered with a mean dose of 56.2 ± 9.4 mg in group 1 and was able to significantly reduce right heart failure incidence, and to demonstrate a significant reduction in pulmonary vascular resistance, pulmonary artery pressure, transpulmonary gradient, and a significant increase in cardiac output. " 03/01/2011 - "In light of its documented protective effects at the myocardial level in heart failure, sildenafil presents a particularly attractive strategy in that it simultaneously targets cardiac remodeling and secondary PH-LHD." 04/01/2016 - "Sildenafil effectively ameliorates LV T-tubule remodeling in TAB mice, revealing a novel mechanism underlying the therapeutic benefits of sildenafil in heart failure." 12/01/2004 - "Oral sildenafil is safe and effective for the evaluation of PH reactivity in heart failure." 09/01/2004 - "Sildenafil was safe and improved erectile function and quality of life in men with moderately severe congestive heart failure."

Related Drugs and Biologics

1.	Sildenafil Citrate (Viagra)
2.	Type 5 Cyclic Nucleotide Phosphodiesterases
3.	Phosphodiesterase 5 Inhibitors
4.	Tadalafil (Cialis)
5.	Bosentan (Tracleer)
6.	Vardenafil Dihydrochloride (Levitra)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Epoprostenol (Prostacyclin)
9.	Endothelin Receptor Antagonists
10.	Antidepressive Agents (Antidepressants)

Related Therapies and Procedures

1.	Therapeutics
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Brachytherapy
4.	Radiotherapy
5.	Renal Dialysis (Hemodialysis)