Brimonidine Tartrate (Alphagan)

A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.

Also Known As:

Alphagan; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate; 5-bromo-6-(imidazolidinylideneamino)quinoxaline; 5-bromo-6-(imidazolin-2-ylamino)quinoxaline; AGN 190342; AGN-190342; Alphagan P; Brimonidine; Brimonidine Purite; Brimonidine Tartrate (1:1); Brimonidine Tartrate (1:1), (S-(R*,R*))-Isomer; Brimonidine Tartrate, (R-(R*,R*))-Isomer; Bromoxidine; Mirvaso; Ratio-Brimonidine; Sanrosa; UK 14,304; UK 14,304-18; UK 14304; UK 14308; UK-14,304-18; UK-14,308; UK-14304; AGN190342; Ratio Brimonidine; UK 14,304 18; UK 14,30418; UK 14,308; UK14,30418; UK14,308; UK14304; 6-quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

Networked: 682 relevant articles (108 outcomes, 162 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - Brimonidine Tartrate: 682
        Timolol Maleate Drug Combination Brimonidine Tartrate: 10

Experts

1.	Stewart, W C: 10 articles (11/2008 - 06/2000)
2.	Park, Ki Ho: 7 articles (03/2021 - 09/2010)
3.	Vidal-Sanz, Manuel: 7 articles (11/2019 - 02/2002)
4.	Day, D G: 7 articles (01/2005 - 06/2000)
5.	Kim, Chan Yun: 6 articles (04/2021 - 09/2007)
6.	Feldman, Steven R: 6 articles (03/2021 - 06/2014)
7.	Hollander, David A: 6 articles (05/2012 - 05/2008)
8.	Stewart, J A: 6 articles (01/2005 - 06/2000)
9.	Kim, Joon Mo: 5 articles (04/2021 - 09/2010)
10.	Goldberg, Ivan: 5 articles (01/2021 - 01/2009)

Related Diseases

1.	Glaucoma 12/01/2021 - "Purpose: The aim of this study was to formulate brimonidine tartrate loaded phase transition microemulsions (PMEs), which undergo phase transition from water in oil (W/O) microemulsions to liquid crystalline (LC) and then oil in water (O/W) microemulsions after instilled into the eye and prolong the precorneal residence time and ocular bioavailability for the effective treatment of glaucoma.Methods" 04/01/2000 - "This study indicates that 0.2% brimonidine acutely associated with beta-blockers is an interesting new combination treatment useful in the management of glaucoma." 12/01/2005 - "To investigate brimonidine-related side effects and the efficacy of brimonidine in lowering intraocular pressure (IOP) in children with primary infantile and secondary glaucoma. " 10/01/2001 - "Safety and efficacy of brimonidine in children with glaucoma." 07/01/2001 - "We evaluated the efficacy of topical brimonidine in visual field preservation and/or improvement in eyes undergoing controlled glaucoma. "
2.	Ocular Hypertension (Glaucoma, Suspect) 06/01/2014 - "The effects of brimonidine on daytime and nighttime intraocular pressure (IOP) and aqueous humor dynamics were evaluated in volunteers with ocular hypertension (OHT). " 06/01/2014 - "Daytime and nighttime effects of brimonidine on IOP and aqueous humor dynamics in participants with ocular hypertension." 03/01/2006 - "[Ocular hypertension in children treated with brimonidine 0.2%. " 12/01/1998 - "Eighteen patients with ocular hypertension were enrolled in a prospective, randomized, double-masked study in which 0.2% brimonidine tartrate, administered twice daily, was compared with its vehicle in a crossover fashion. " 11/01/2001 - "Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension."
3.	Erythema 09/01/2015 - "Brimonidine gel is a highly selective α2-adrenergic receptor agonist with potent vasoconstrictive effects, which leads to significant reduction of persistent facial erythema in the majority of patients when applied once daily. " 02/01/2017 - "With the application of brimonidine only on half of his face, skin analysis images, clinician's and patient's assessment showed that there was significant improvement in the erythema. " 11/01/2016 - "Approximately 80% of patients treated with brimonidine experience a significant improvement without erythema worsening as an adverse event. " 01/01/2020 - "This study demonstrates that brimonidine gel is effective in reducing the facial erythema of AFS. " 01/01/2015 - "Initial improvement was followed by progressive worsening of baseline erythema several hours following treatment, only improved with subsequent applications of additional Mirvaso. "
4.	Open-Angle Glaucoma (Glaucoma, Open Angle) 05/01/2018 - "Efficacy of three different formulations of brimonidine for control of intraocular pressure in primary open-angle glaucoma: A 6-week randomized trial." 09/01/2001 - "The purpose of this study was to report the acute and chronic effects of brimonidine 0.2% on intraocular pressure (IOP) and pulsatile ocular blood flow (pOBF) in patients with primary open-angle glaucoma (POAG). " 01/01/2015 - "A 78-year-old male with a history of primary open angle glaucoma presented with symptoms of unilateral blurry vision, irritation, and redness shortly after starting brimonidine exclusively in the right eye. " 04/01/2011 - "Sustained release ocular inserts of brimonidine tartrate for better treatment in open-angle glaucoma." 04/01/2004 - "To compare the efficacy and safety of unoprostone versus brimonidine both given twice daily in ocular hypertensive or primary open-angle glaucoma subjects. "
5.	Rosacea (Acne Rosacea) 11/01/2017 - "In this study, we observed that clinical features of rosacea induced by LL-37 in Balb/c mice were improved after the application of brimonidine gel, and we also showed a marked decrease in the number of inflammatory cells, especially mast cells (MCs) histologically. " 07/01/2014 - "Few studies have looked at the effectiveness of the novel treatment, brimonidine topical gel 0.33%, trademark name Mirvaso®, in the treatment of rosacea. " 11/01/2017 - "However, there is no study of how brimonidine has an effect on rosacea-related immune cells or mechanisms in the skin to improve rosacea. " 01/01/2018 - "Brimonidine gel, originally approved for the treatment of facial rosacea, causes direct vasoconstriction and possesses extensive utilization in dermatologic fields. " 11/01/2017 - "Brimonidine is a highly selective α2-adrenergic receptor agonist approved by the FDA for the treatment of rosacea. "

Related Drugs and Biologics

1.	Timolol (Blocadren)
2.	dorzolamide (Trusopt)
3.	brinzolamide (Azopt)
4.	Latanoprost (Xalatan)
5.	Ophthalmic Solutions (Eye Drops)
6.	Brimonidine Tartrate (Alphagan)
7.	Adrenergic Agonists (Adrenergic Receptor Agonist)
8.	Betaxolol (Kerlon)
9.	Retinaldehyde (Retinal)
10.	Travoprost (Travatan)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Phacoemulsification
4.	Trabeculectomy (Trabeculoplasty)
5.	Injections