ELAV-Like Protein 1

An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.

Also Known As:

ELAVL1 protein; HuR Antigen; HuR Paraneoplastic Encephalomyelitis Antigen; HuR Protein; Antigen, HuR; ELAV Like Protein 1; Protein, HuR; protein, ELAVL1

Networked: 82 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - RNA Recognition Motif Proteins
        ELAV Proteins: 25
        ELAV-Like Protein 1: 82
        human ELAVL1 protein
        mouse Elavl1 protein
        rat Elavl1 protein
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - RNA Recognition Motif Proteins
        ELAV Proteins: 25
        ELAV-Like Protein 1: 82
        human ELAVL1 protein
        mouse Elavl1 protein
        rat Elavl1 protein

Experts

1.	Ristimäki, Ari: 6 articles (09/2016 - 11/2003)
2.	Haglund, Caj: 5 articles (09/2016 - 11/2003)
3.	Wang, Jun: 4 articles (01/2014 - 12/2007)
4.	Denkert, Carsten: 4 articles (02/2008 - 01/2004)
5.	Dietel, Manfred: 4 articles (02/2008 - 01/2004)
6.	Weichert, Wilko: 4 articles (02/2008 - 01/2004)
7.	Wang, Baocheng: 3 articles (01/2014 - 01/2009)
8.	Niesporek, Silvia: 3 articles (02/2008 - 08/2004)
9.	Noske, Aurelia: 3 articles (02/2008 - 08/2004)
10.	Pergaris, Alexandros: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Pain (Aches) 01/01/2021 - "administered ASO reduced spinal HuR protein and relieved pain hypersensitivity with a similar efficacy to i.t. "
2.	Hypersensitivity (Allergy) 01/01/2021 - "administered ASO reduced spinal HuR protein and relieved pain hypersensitivity with a similar efficacy to i.t. "
3.	Neoplasms (Cancer) 05/27/2022 - "Herein, we review HuR protein structure, function, and its regulation, as well as its implications in the pathogenesis, progression, and treatment of hepatobiliary cancers. " 04/01/2021 - "HuR protein has been demonstrated to be an important regulatory factor in macrophage-mediated angiogenesis, a process in which macrophages are critical for tumor progression. " 01/01/2021 - "Because HuR functionality in cancer cells is dependent on HuR dimerization and its nuclear/cytoplasmic shuttling, we developed a new class of molecules targeting HuR protein dimerization. " 01/01/2019 - "For this reason, downregulation in HuR protein levels or inhibition of HuR biological function are, nowadays, attractive goals in cancer research. " 09/27/2016 - "Numerous cancers display increased HuR protein levels and its high cytoplasmic levels has been associated with a worse prognosis.In"
4.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Furthermore, we demonstrated that the TNBC breast cancer cell lines i.e., MDA-MB-231 and MDA-MB-468 are good model systems to study HuR protein, as they both exhibit a significant amount of cytoplasmic HuR (active form). " 10/15/2010 - "We further demonstrate that the level of miR-16 was inversely correlated with HuR protein level in human breast carcinoma. " 11/01/2009 - "Re-establishing miR-125a expression in breast cancer cells decreased HuR protein level and inhibited cell growth. " 09/01/2013 - "Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy." 10/13/2021 - "FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway."
5.	Neoplasm Metastasis (Metastasis) 06/05/2019 - "In conclusion, present study proved that FAM83H-AS1 contributes to the radioresistance and cell metastasis in ovarian cancer through stabilizing HuR protein." 01/01/2022 - "HuR protein overexpression has undoubtedly been linked to an increased risk of tumor growth, progression and metastasis, rendering it a potential therapeutic target candidate in cancer. " 10/13/2021 - "FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway." 02/05/2023 - "HuR protein not only regulates the mRNA stability of tumor growth-related genes, but it also regulates the mRNA stability of a variety of cancer metastasis-related genes, such as Snail, Cox-2, and Vegf-c. " 02/05/2023 - "Eltrombopag Inhibits Metastasis in Breast Carcinoma by Targeting HuR Protein."

Related Drugs and Biologics

1.	Antigens
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	eltrombopag
5.	MicroRNAs (MicroRNA)
6.	Biomarkers (Surrogate Marker)
7.	Gemcitabine
8.	Cyclooxygenase 2 (Cyclooxygenase-2)
9.	RNA (Ribonucleic Acid)
10.	Long Noncoding RNA

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Therapeutics