ELAV-Like Protein 4

An RRM protein which binds AU-rich sequences in the 3' UNTRANSLATED REGIONS of mRNAs for PROTO-ONCOGENE PROTEINS C-FOS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; and GAP-43 PROTEIN. It functions in neuron-specific RNA processing.

Also Known As:

Networked: 21 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	DerHartunian, Meleeneh Kazarian: 2 articles (12/2016 - 10/2016)
2.	Laird-Offringa, Ite A: 2 articles (12/2016 - 10/2016)
3.	Pulido, Mario A: 2 articles (12/2016 - 10/2016)
4.	Kong, Meng: 1 article (10/2017)
5.	Liu, Yuanmei: 1 article (10/2017)
6.	Wu, Yurui: 1 article (10/2017)
7.	Chen, Zhenwen: 1 article (01/2017)
8.	Du, Xiaoyan: 1 article (01/2017)
9.	Huo, Xueyun: 1 article (01/2017)
10.	Li, Changlong: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 06/03/2009 - "Interestingly, all SCLC express the onconeural HuD antigen, and clinically useful tumor immune responses can be detected in up to 20% of patients, yet the paraneoplastic neurologic syndrome is extremely rare. " 07/01/2000 - "Non-idiotype antibody responses (anti-mouse-IgG3 or anti-tumor nuclear HUD antigen) had no apparent impact on PFS or survival. " 07/01/1999 - "DNA vaccination with mouse HuD antigen suppressed HuD-expressing tumor growth in a murine SCLC model." 07/01/1999 - "There is a clinically significant correlation between the presence of an antibody against the paraneoplastic encephalomyelitis antigen HuD and the limitation of tumor spread in patients with small-cell lung cancer (SCLC). " 12/19/2014 - "The correlation between high titers of circulating anti-HuD antibodies in patients and spontaneous tumor remission suggests that the HuD-antigen might be a potential molecular target for immunotherapy. "
2.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/2017 - "Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis." 12/01/2016 - "The data are related to the article "Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4" (M.A. " 10/15/2016 - "Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4." 09/01/2003 - "Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons. " 03/01/2002 - "It has been demonstrated that small cell lung cancer (SCLC) cell lines are susceptible to NK cells and lymphokine activated killer (LAK) cells, and HuD antigen is assumed to be a target molecule on SCLC cells for host cellular immunity. "
3.	Nervous System Paraneoplastic Syndromes 10/01/1995 - "Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice." 01/01/1994 - "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34." 10/18/1991 - "A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. " 06/03/2009 - "Interestingly, all SCLC express the onconeural HuD antigen, and clinically useful tumor immune responses can be detected in up to 20% of patients, yet the paraneoplastic neurologic syndrome is extremely rare. " 08/08/1998 - "The expression of mRNA for the neuronal antigen HuD (Elavl4) associated with paraneoplastic encephalomyelitis and sensory neuronopathy was evaluated in the developing and adult rat nervous system. "
4.	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 03/01/2011 - "In a possible link with the autoimmune disease human T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis, A6 also recognizes a self peptide from the neuronal protein HuD in the context of HLA-A2. "
5.	T-Cell Leukemia (Leukemia, T Cell) 03/01/2011 - "In a possible link with the autoimmune disease human T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis, A6 also recognizes a self peptide from the neuronal protein HuD in the context of HLA-A2. "

Related Drugs and Biologics

1.	Antibodies
2.	Complementary DNA (cDNA)
3.	RNA-Binding Proteins (RNA-Binding Protein)
4.	Immunoglobulin G (IgG)
5.	Antigens
6.	ELAV Proteins
7.	HLA-A2 Antigen (HLA A2 Antigen)
8.	Messenger RNA (mRNA)
9.	Proteins (Proteins, Gene)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Immunotherapy