Glucagon-Like Peptide-2 Receptor

A receptor for GLUCAGON-LIKE PEPTIDE 2 (GLP-2) that is expressed on the surface of intestinal cells as well as neural cells. GLP-2 and other peptides act through GLP-2R to regulate cellular responses to BLOOD GLUCOSE, INFLAMMATION, and FOOD INTAKE.

Also Known As:

GLP-2 Receptor; GLP-2R Receptor; GLP2R Protein; Glucagon-Like Peptide 2 Receptor; GLP 2 Receptor; GLP 2R Receptor; Glucagon Like Peptide 2 Receptor; Peptide-2 Receptor, Glucagon-Like; Protein, GLP2R; Receptor, GLP-2; Receptor, GLP-2R; Receptor, Glucagon-Like Peptide-2

Networked: 25 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Drucker, Daniel J: 3 articles (09/2010 - 10/2005)
2.	Adeli, Khosrow: 2 articles (01/2019 - 01/2018)
3.	Alvares, Danielle: 2 articles (01/2019 - 01/2018)
4.	Brubaker, Patricia L: 2 articles (01/2018 - 09/2009)
5.	Hornby, Pamela J: 2 articles (05/2011 - 05/2010)
6.	Moore, Beverley A: 2 articles (05/2011 - 05/2010)
7.	Ge, Hong: 1 article (01/2022)
8.	Li, Ning: 1 article (01/2022)
9.	Pu, Chenwei: 1 article (01/2022)
10.	Song, Bin: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 10/10/2012 - "If these effects are replicated in vivo the GLP-2 receptor may present a therapeutic target in intestinal inflammation." 05/01/2010 - "GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus." 01/01/2019 - "Nevertheless, GLP-1 and GLP-2 receptor agonists have been associated with alterations in lipid metabolism and hepatic and systemic inflammation, pathological abnormalities characteristic of NAFLD. "
2.	Ileus 05/01/2010 - "GLP-2 receptor agonism ameliorates inflammation and gastrointestinal stasis in murine postoperative ileus."
3.	Obesity 10/30/2019 - "As gut microbial imbalances and maladaptive host responses have been implicated in the pathology of obesity and diabetes, this study aimed to determine the effects of pharmacologically stimulated GLP-1 and GLP-2 receptor function on the gut microbiome composition in diet-induced obese (DIO) mice. " 03/01/2012 - "In the caudate nucleus with increased BMI we saw the upregulation of known obesity related genes (the insulin receptor (INSR) and the glucagon-like peptide-2 receptor (GLP2R)), apoptosis related genes, and altered expression of genes involved in various metabolic processes. " 09/01/2010 - "We examined the importance of GLP-2 receptor (GLP-2R) signaling for glucose homeostasis in multiple models of metabolic stress, diabetes, and obesity. "
4.	Neoplasms (Cancer) 11/25/2012 - "Therefore, the GLP-2 receptor expression was assessed in 237 tumor and 148 non-neoplastic tissue samples with in vitro receptor autoradiography. " 05/01/2011 - "The therapeutic utility of GLP-2 receptor agonists is limited by concern that it predisposes patients to gastrointestinal cancers, or their re-occurrence in cancer patients. " 08/01/2011 - "Our study suggested that Glucagon like peptide-2 receptor expression is not a factor in adenoma-cancer pathogenesis. "
5.	Carcinogenesis 09/01/2009 - "Taken together, these studies indicate that chronic treatment with GLP-2 enhances colon carcinogenesis, whereas antagonism of the GLP-2 receptor decreases dysplasia, with possible implications for human therapy."

Related Drugs and Biologics

1.	Glucagon-Like Peptide 1 (GLP 1)
2.	Glucagon-Like Peptides (Enteroglucagon)
3.	Cisplatin (Platino)
4.	A-factor (Streptomyces)
5.	Glucagon-Like Peptide 2
6.	Messenger RNA (mRNA)
7.	Insulin Receptor
8.	Pro-Opiomelanocortin (Proopiomelanocortin)
9.	Peptides (Polypeptides)
10.	Lipoproteins (Lipoprotein)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)