Ataxin-10

An ataxin that is associated with the survival of cerebellar neurons. Expansion of the ATTCT pentanucleotide in the ATXN10 coding region is associated with SPINOCEREBELLAR ATAXIA 10.

Also Known As:

Networked: 20 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ashizawa, Tetsuo: 6 articles (01/2017 - 05/2006)
2.	McFarland, Karen N: 4 articles (01/2017 - 09/2012)
3.	Landrian, Ivette: 3 articles (01/2017 - 01/2013)
4.	Liu, Jilin: 3 articles (01/2017 - 01/2013)
5.	Rasmussen, Astrid: 3 articles (01/2017 - 01/2013)
6.	Teive, Hélio A G: 3 articles (03/2014 - 06/2010)
7.	März, Pia: 3 articles (07/2006 - 08/2004)
8.	Backs, Johannes: 2 articles (01/2020 - 02/2016)
9.	Bauer, Ralf: 2 articles (01/2020 - 02/2016)
10.	Baysal-Temel, Ezgi: 2 articles (01/2020 - 02/2016)

Related Diseases

1.	Spinocerebellar Ataxia 10 06/10/2010 - "Our subsequent studies indicated that neither a gain nor a loss of function of ataxin 10 is likely the major pathogenic mechanism of SCA10. " 01/01/2015 - "Ultimately, a test for ATAXIN-10 mutation was positive thus confirming the diagnosis of SCA10 in father and his four children. " 09/01/2012 - "SCA10 is caused by a pentanucleotide repeat expansion of the ATTCT motif within intron 9 of ATAXIN 10 (ATXN10). " 09/01/2011 - "We propose a model in which Plk1 phosphorylation of Ataxin-10 influences its degradation and cytokinesis, which may provide mechanistic insight to SCA10's pathogenesis." 08/22/2006 - "In addition, we generated Sca10 (mouse ataxin 10 homolog)-null mice and addressed the role of Sca10 gene dosage on the cerebellum. "
2.	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 05/01/2010 - "Evidence against haploinsuffiency of human ataxin 10 as a cause of spinocerebellar ataxia type 10." 08/22/2006 - "The role of ataxin 10 in the pathogenesis of spinocerebellar ataxia type 10." 08/12/2005 - "Spinocerebellar ataxia type 10 is an autosomal dominant disorder caused by expansion of a pentameric repeat tract (ATTCT.AGAAT)(n) in intron 9 of the gene that encodes ataxin-10. " 11/01/2007 - "Spinocerebellar ataxia type 10 (SCA10) is associated with expansion of (ATTCT)n repeats (where n is the number of repeats) within the ataxin 10 (ATX10/E46L) gene. " 01/01/2017 - "Spinocerebellar ataxia type 10 (SCA10), an autosomal dominant cerebellar ataxia disorder, is caused by a non-coding ATTCT microsatellite repeat expansion in the ataxin 10 gene. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 07/21/2006 - "Here, we show that the neurodegenerative disease protein ataxin-10 (Atx-10) is associated with cytoplasmic OGT p110 in the brain. " 03/01/2014 - "Spinocerebellar ataxia type 10 (SCA10), an autosomal dominant neurodegenerative disorder, is the result of a non-coding, pentanucleotide repeat expansion within intron 9 of the Ataxin 10 gene. " 08/20/2004 - "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons."
4.	Cerebellar Ataxia (Dysmetria) 01/01/2017 - "Spinocerebellar ataxia type 10 (SCA10), an autosomal dominant cerebellar ataxia disorder, is caused by a non-coding ATTCT microsatellite repeat expansion in the ataxin 10 gene. " 01/01/2013 - "Spinocerebellar ataxia type 10 (SCA10), an autosomal dominant cerebellar ataxia, is caused by the expansion of the non-coding ATTCT pentanucleotide repeat in the ATAXIN 10 gene. " 08/01/2009 - "Interaction between Ataxin 10 and A/M2 would explain why influenza virus infection or influenza vaccine innoculation causes acute cerebellar ataxia. "
5.	Neoplasms (Cancer) 01/01/2020 - "'Corrigendum to "Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia" [Molecular Metabolism 5 (2) (2015) 67-78]'." 02/01/2016 - "As Ataxin-10 serum levels were also found to be elevated in human cachectic cancer patients, the identification of Ataxin-10 as part of a cachexokine cocktail now provides a rational approach towards personalized predictive, diagnostic and therapeutic measures in cancer cachexia." 02/01/2016 - "As a prototypical example, engineered secretion of Ataxin-10 from non-cachexia-inducing cells was sufficient to induce cachexia phenotypes in cardiomyocytes, correlating with elevated Ataxin-10 serum levels in murine and human cancer cachexia models. " 02/01/2016 - "Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia."

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