Symptom Flare Up

A transient exacerbation of symptoms of an existing disease or condition.

Also Known As:

Acute Symptom Flare; Symptom Exacerbation; Symptom Exaggeration; Symptom Flare-up; Symptom Flareup; Symptom Flaring Up; Symptom Increase; Symptom Magnification; Symptom Worsening; Acute Symptom Flares; Exacerbation, Symptom; Exaggeration, Symptom; Flare Up, Symptom; Flare Ups, Symptom; Flare-up, Symptom; Flare-ups, Symptom; Flareup, Symptom; Flareups, Symptom; Flaring Up, Symptom; Increase, Symptom; Magnification, Symptom; Symptom Exacerbations; Symptom Exaggerations; Symptom Flare Ups; Symptom Flare, Acute; Symptom Flare-ups; Symptom Flareups; Symptom Magnifications; Worsening, Symptom

Networked: 277 relevant articles (15 outcomes, 41 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Disease Attributes: 18
    - Recurrence
      - Symptom Flare Up: 277

Related Diseases

1.	Tics (Tic)
2.	Asthma (Bronchial Asthma)
3.	Chronic Obstructive Pulmonary Disease (COPD)
4.	Inflammation (Inflammations)
5.	Streptococcal Infections (Streptococcal Infection)

Experts

1.	Bacharier, Leonard B: 4 articles (01/2022 - 01/2022)
2.	Bateman, Eric D: 4 articles (01/2022 - 01/2022)
3.	Boulet, Louis-Philippe: 4 articles (01/2022 - 01/2022)
4.	Brightling, Christopher E: 4 articles (01/2022 - 01/2022)
5.	Brusselle, Guy G: 4 articles (01/2022 - 01/2022)
6.	Buhl, Roland: 4 articles (01/2022 - 01/2022)
7.	Cruz, Alvaro A: 4 articles (01/2022 - 01/2022)
8.	Drazen, Jeffrey M: 4 articles (01/2022 - 01/2022)
9.	Duijts, Liesbeth: 4 articles (01/2022 - 01/2022)
10.	FitzGerald, J Mark: 4 articles (01/2022 - 01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Symptom Flare Up:

1.	Penicillins (Penicillin)FDA Link 06/15/1999 - "Because of the failure to achieve an acceptable level of streptococcal prophylaxis, no conclusions can be drawn from this study regarding the efficacy of penicillin prophylaxis in preventing tic or OCD symptom exacerbations. " 01/01/2004 - "In contrast, the efficacy of penicillin prophylaxis in preventing tic or obsessive-compulsive symptom exacerbations in children with PANDAS remains doubtful. " 06/15/1999 - "Because penicillin prophylaxis has proven to be effective in preventing recurrences of rheumatic fever, it was postulated that it might also prevent streptococcal-triggered neuropsychiatric symptom exacerbations in children with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS). " 04/01/2005 - "Penicillin and azithromycin prophylaxis were found to be effective in decreasing streptococcal infections and neuropsychiatric symptom exacerbations among children in the PANDAS subgroup."
2.	SteroidsIBA 01/01/2004 - "The efficacy of FP was superior to SCG with fewer cases of symptom worsening, exacerbations, and requirements for oral steroid treatment and more symptom-free days and days without use of rescue treatment. " 01/01/2021 - "COVID-19 symptom exacerbation is a leading cause of early ACHE after COVID-19 hospitalization, and steroid use during index hospitalization may reduce early reencounters. " 11/01/2013 - "Severe asthmatics have persistent symptoms, frequent symptom exacerbation, and severe airway obstruction even when taking high-dose inhaled steroids. " 12/01/2022 - "High-dose steroids (n = 14) and intravenous immunoglobulin (n = 13) were the most prescribed acute treatments among those receiving an acute treatment at time of survey completion (n = 36), with symptom exacerbations or myasthenic crises being the most common reasons for acute treatment. " 04/01/2008 - "Intranasal steroids (INS) have been shown to reduce components of respiratory inflammation and increase symptom relief for ARS when used alone or combined with antibiotics. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 11/13/2001 - "Prophylactic antibiotic treatments have thus far not been shown to be helpful in preventing symptom exacerbations. " 12/01/2005 - "Although PANDAS patients have been reported to improve after therapeutic plasma exchange, and antibiotics may prevent symptom exacerbations, immune-based treatments should not be routinely given. " 11/01/2017 - "Exacerbations were identified using predefined criteria for symptom worsening and treatment with systemic corticosteroids and/or antibiotics and/or hospitalization. " 04/01/2008 - "Intranasal steroids (INS) have been shown to reduce components of respiratory inflammation and increase symptom relief for ARS when used alone or combined with antibiotics. "
4.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/01/2006 - "In conclusion, long-term treatment of PTSD with SSRIs improves the psychiatric and clinical outcome of patients with the disorder and prevents relapse and symptom exacerbation. " 01/01/2003 - "Literature on antidepressant use is mixed, with reports of symptom worsening with tricyclic antidepressants but improvement with selective serotonin reuptake inhibitors. "
5.	Bronchodilator Agents (Bronchodilators)IBA 12/01/2008 - "Combined group analysis (N = 45) revealed that only six symptom exacerbations occurred during 1,125 person-sessions of swimming and golf (all resolved with bronchodilator therapy), 92% of parents were very or extremely satisfied with the program, and post-exercise decreases were observed in asthma symptom severity scores (9.3-7.3, P < 0.001), improved parental QOL (4.9-5.4, P < 0.001), and reduced urgent physician visits for asthma (1.3-0.2 visits per person, P = 0.04). " 01/01/1993 - "These findings suggest that patients with bronchospasm requiring xanthines or inhaled steroids who are prescribed topical timolol for glaucoma may be at significantly increased risk of pulmonary symptom exacerbation requiring additional bronchodilator therapy. "
6.	Antidepressive Agents (Antidepressants)IBA 11/01/2003 - "Less education, being unemployed, worse mental health, more use of sedating and antidepressant medications, and more somatic attributions for their symptoms were associated with worsening symptom severity over time. " 01/01/2003 - "Literature on antidepressant use is mixed, with reports of symptom worsening with tricyclic antidepressants but improvement with selective serotonin reuptake inhibitors. "
7.	Olanzapine (Zyprexa)FDA Link 12/01/2006 - "Consequent to the differential rates of discontinuation due to poor response/symptom worsening, the olanzapine-treated patients experienced a significantly greater likelihood of overall treatment completion (53.9% vs. 39.3%; P < 0.001) and a significantly longer duration of treatment (19.1 vs. 16.1 weeks; P < 0.0001) than other atypical-treated patients. " 04/01/2007 - "To evaluate the relationship of dose decrease, symptom worsening, and baseline covariates on subsequent relapse during olanzapine treatment in patients with schizophrenia or schizoaffective disorder. " 12/01/2006 - "The predominant reason for the significantly lower discontinuation rate of treatment for patients taking olanzapine compared with that of patients taking other atypical antipsychotics was the significantly higher dropout rates in other atypical antipsychotics because of poor response/symptom worsening." 12/01/2006 - "The rate of discontinuation due to poor response/symptom worsening significantly varied by treatment (olanzapine, 14.23%, vs. other atypical antipsychotics, 24.60%; P < 0.0001). "
8.	Fluticasone (Cutivate)FDA LinkGeneric 04/01/2008 - "Four children who required inhaled fluticasone propionate administration for significant symptom worsening had no statistically significant increase in TGF-BETA1-secreting T cells at 12 months of SIT, in contrast to 12 children without inhaled corticosteroid treatment. " 11/01/2008 - "To observe the efficacy of combination therapy with inhaled salmeterol/fluticasone and tiotropium in reducing the frequency of acute episodes of symptom exacerbation and improving lung function and health status in chronic obstructive pulmonary disease (COPD). "
9.	tocilizumab (atlizumab)FDA Link 01/01/2020 - "Thus, we started treatment with tocilizumab, which allowed of tapering of the PSL dose without his symptom exacerbations, and effectively improved his Expanded Disability Status Scale score. " 05/01/2013 - "CRP levels were high when tocilizumab was restarted in patients with RA symptom flare-ups (P = 0.0010, versus patients without RA symptom flare-ups). "
10.	Azithromycin (Zithromax)FDA LinkGeneric 04/01/2005 - "Penicillin and azithromycin prophylaxis were found to be effective in decreasing streptococcal infections and neuropsychiatric symptom exacerbations among children in the PANDAS subgroup."

Therapies and Procedures

1.	Therapeutics 01/01/2021 - "Among all medical therapies, there were high rates of treatment failure or symptom worsening in over three-quarters of patients in our study. " 09/25/2023 - "Over the 12 months following the initial flare-up, patients who started triple therapy earlier (within 30 days) had fewer subsequent symptom flare-ups, fewer hospital admissions, and lower healthcare costs compared with patients who started triple therapy later (31–180 days). " 03/01/2023 - "Bilateral GPi-DBS can be an effective therapeutic option for severe cases of TD resistant to oral pharmacological therapies, even though rare cases of symptom worsening or lack of improvement have also been reported." 01/01/2019 - "Therapy transfers may impair the quality of the therapeutic alliance and increase symptom severity. " 12/01/2017 - "Symptom exacerbations were documented during therapy for 19% of patients; therapy changes resulted in good response. "
2.	Ambulatory Care (Outpatient Care) 09/01/2012 - "Among the 83 study patients, 78 had at least one of the following: worsening symptom(s), HF-related sign(s), and/or elevated BNP levels (≥3-fold increase) at one or more clinic visits. " 10/18/2023 - "The weekly responses obtained from e-PRO revealed that symptom exacerbations peaked outside of clinic visits. " 03/21/2022 - "Avoiding interruptions and dropout in outpatient care can prevent mental illness symptom exacerbation and costly crisis services, such as emergency room visits and inpatient psychiatric hospitalization. " 02/01/2015 - "Twenty-one patients, ages 4-17 years (average 10.63±2.34 years, 13 males), with a clinical diagnosis of Tourette's syndrome (TS) or chronic tic disorder (CTD), were selected based on having clinic visits that coincided with a tic symptom exacerbation and a remission. "
3.	Duration of Therapy 12/01/2006 - "Consequent to the differential rates of discontinuation due to poor response/symptom worsening, the olanzapine-treated patients experienced a significantly greater likelihood of overall treatment completion (53.9% vs. 39.3%; P < 0.001) and a significantly longer duration of treatment (19.1 vs. 16.1 weeks; P < 0.0001) than other atypical-treated patients. "
4.	Wearable Electronic Devices 09/16/2021 - "This study aimed to test whether EOV measured by the wearable device Fitbit can predict COVID-19 symptom exacerbation. " 08/09/2021 - "This study aims to investigate the feasibility of using wearable devices and self-reported technologies to identify symptom exacerbation correlates and relapse in patients with schizophrenia. "
5.	Palliative Care (Palliative Therapy) 12/01/2023 - "Patients with life-limiting or palliative illnesses represent a challenge for emergency departments because, despite the growing availability of specialized outpatient palliative care resources at home, patients often present during symptom exacerbations or when family caregivers become overwhelmed. " 05/01/2022 - "The wide range of symptoms and symptom worsening suggest the need for individualized care, possibly extended home healthcare, and the inclusion of a more formal palliative care course for staff on symptom management." 02/01/2022 - "Patients listed for lung re-transplant also benefit from palliative care involvement to address frequent symptom exacerbations, hospitalizations, and higher morbidity and mortality. " 01/01/2023 - "This study compared the prevalence of symptom worsening and explored associated factors between patients with advanced cancer receiving palliative care in palliative care units (PCUs) and at home. " 01/01/2023 - "After adjusting for patient background, the prevalence of symptom worsening was not different between patients with advanced cancer receiving palliative care at home and in PCUs."