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AF38469

structure in first source

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - AF38469: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - AF38469: 6

Experts

1.	Denham, Jim W: 1 article (01/2020)
2.	Faulkner, Sam: 1 article (01/2020)
3.	Gao, Fangfang: 1 article (01/2020)
4.	Griffin, Nathan: 1 article (01/2020)
5.	Hondermarck, Hubert: 1 article (01/2020)
6.	Jiang, Chen Chen: 1 article (01/2020)
7.	Jobling, Phillip: 1 article (01/2020)
8.	King, Simon J: 1 article (01/2020)
9.	Li, Xiang: 1 article (01/2020)
10.	Chen, Cheng: 1 article (01/2019)

Related Diseases

1.	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 09/22/2023 - "Utilizing CLN2 and CLN3 Batten disease mouse models, we performed a short-term efficacy study and show that treatment with AF38469 prevents the accumulation of lysosomal storage material and the development of neuroinflammation, key disease associated pathologies. "
2.	Neuroinflammatory Diseases 09/22/2023 - "Utilizing CLN2 and CLN3 Batten disease mouse models, we performed a short-term efficacy study and show that treatment with AF38469 prevents the accumulation of lysosomal storage material and the development of neuroinflammation, key disease associated pathologies. "
3.	Neoplasms (Cancer) 04/27/2023 - "In vitro, sortilin was detected in 11 brain-cancer-patient-derived cell lines at the anticipated molecular weight of 100 kDa. Interestingly, targeting sortilin with the orally bioavailable small molecule inhibitor AF38469 resulted in decreased GBM invasiveness, but cancer cell proliferation was not affected, showing that sortilin is targetable in GBM. " 11/20/2018 - "Importantly, an orally bioavailable small molecule (AF38469) targeting sortilin, blocked GRN A-induced lung metastases and prevented cancer cell infiltration of the skin. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2020 - "Sortilin inhibition by siRNA and the pharmacologic inhibitor AF38469 strongly reduced the adhesion and invasion of pancreatic cancer cells without affecting cell survival and viability. "
5.	Obesity 01/01/2019 - "AF38469 treatment did not affect diet-induced obesity or insulin resistance, but was associated with reduced hepatic VLDL secretion and higher hepatic cholesterol 7α-hydrolase expression in WD-fed mice. "

Related Drugs and Biologics

1.	sortilin
2.	Small Interfering RNA (siRNA)
3.	Cholesterol
4.	Antineoplastic Agents (Antineoplastics)