callyspongiolide

01/01/2021 - "Mitochondrial dysfunction induced by callyspongiolide promotes autophagy-dependent cell death."
01/01/2021 - "Moreover, molecular biology studies revealed that callyspongiolide causes lysosomal dysfunction, which induces cellular iron depletion and leads to mitochondrial dysfunction and subsequent cytotoxicity. "
01/01/2021 - "Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion."
01/01/2021 - "We report that Callyspongiolide R form at C-21 (cally2R) causes mitochondrial dysfunction by inhibiting mitochondrial complex I or II, leading to a disruption of mitochondrial membrane potential and a deprivation of cellular energy. "
01/01/2021 - "Although our approach was unable to reveal the direct protein targets of callyspongiolide, unique phenomena observed only by TS-FITGE provided critical insight into the mechanism of action of callyspongiolide and specifically its cytotoxic activity via induction of mitochondrial dysfunction through cellular iron depletion caused by lysosomal deacidification, which occurred independent of known programmed cell death pathways."

01/01/2021 - "Callyspongiolide is a marine macrolide known to induce caspaseindependent cancer cell death. "
01/01/2021 - "The highly cytotoxic marine natural product callyspongiolide holds great promise as a warhead of antibody-drug conjugate in cancer therapeutics; however, the mechanism underlying its cytotoxicity remains unclear. "
01/01/2021 - "Finally, the combination of cally2R with known anti-cancer drugs, such as gefitinib, sorafenib, and rapamycin, led to synergistic cell death, implicating potential therapeutic applications of callyspongiolide for future treatments. "