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1- benzyl- 3- (p- hydroxymethylphenyl)- 5- methylfuro(3,2- c)pyrazole

structure in first source

Also Known As:

CLC604

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-benzyl-3-(p-hydroxymethylphenyl)-5-methylfuro(3,2-c)pyrazole: 1
  - Furans: 85
    - 1-benzyl-3-(p-hydroxymethylphenyl)-5-methylfuro(3,2-c)pyrazole: 1

Experts

1.	Chou, Li-Chen: 1 article (10/2013)
2.	Chung, Chao-Ho: 1 article (10/2013)
3.	Huang, Chi-Hung: 1 article (10/2013)
4.	Huang, Li-Jiau: 1 article (10/2013)
5.	Kuo, Sheng-Chu: 1 article (10/2013)
6.	Lee, Fang-Yu: 1 article (10/2013)
7.	Lee, Jang-Chang: 1 article (10/2013)
8.	Lien, Jin-Chemg: 1 article (10/2013)
9.	Way, Tzong-Der: 1 article (10/2013)
10.	Wu, Jia-Chiun: 1 article (10/2013)

Related Diseases

1.

Neoplasms (Cancer)

10/01/2013 - "Moreover, we found that CLC604 significantly enhanced the antitumor efficacy of clinical drugs against HER2-overexpressing tumors and efficiently reduced HER2-induced drug resistance in vitro and in vivo. "
10/01/2013 - "Among the test compounds, (1-benzyl-3-(p-hydroxymethylphenyl)-5-methylfuro[3,2-c]pyrazol) (CLC604), an isosteric analogue of YC-1, significantly suppressed the expression of HER2, and preferentially inhibited cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. "
10/01/2013 - "These findings suggest that CLC604 should be developed further as a novel antitumor drug candidate for the treatment of drug-resistant cancer."
10/01/2013 - "CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo."

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Antineoplastic Agents (Antineoplastics)