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5- ((1- (2,6- dichlorobenzyl)piperidin- 4- yl)methoxy)quinazoline- 2,4- diamine

inhibits DcpS protein

Also Known As:

5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine dihydrochloride; DI57495; RG3039

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine: 3

Experts

1.	Yamauchi, Takuji: 1 article (01/2019)
2.	Cherry, Jonathan J: 1 article (01/2017)
3.	Fadeyi, Olugbeminiyi: 1 article (01/2017)
4.	Foley, Timothy L: 1 article (01/2017)
5.	Gopalsamy, Ariamala: 1 article (01/2017)
6.	Jones, Lyn H: 1 article (01/2017)
7.	Kyne, Robert E: 1 article (01/2017)
8.	LaRosa, Gregory: 1 article (01/2017)
9.	Liu, Shenping: 1 article (01/2017)
10.	Loria, Paula M: 1 article (01/2017)

Related Diseases

1.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 07/01/2015 - "We sought to determine DcpS target genes in mammalian cells using a cell-permeable DcpS inhibitor compound, RG3039 initially developed for therapeutic treatment of spinal muscular atrophy. " 01/01/2017 - "The C-5 substituted 2,4-diaminoquinazoline RG3039 (compound 1), a member of a chemical series that was identified and optimized using an SMN2 promoter screen, prolongs survival and improves motor function in a mouse model of spinal muscular atrophy (SMA). "
2.	Leukemia 01/01/2019 - "Importantly, RG3039 exhibited anti-leukemia effects in PDX models. "

Related Drugs and Biologics

1.	2,4-diaminoquinazoline