HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

1- (2- (1- (2- aminopyrimidin- 4- yl)- 2- ((2- methoxyethyl)amino)- 1H- 1,3- benzodiazol- 6- yl)ethynyl)cyclohexan- 1- ol

inhibits group II p21-activated kinase; structure in first source

Also Known As:

GNE-2861

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 1-(2-(1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-1,3-benzodiazol-6-yl)ethynyl)cyclohexan-1-ol: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 1-(2-(1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-1,3-benzodiazol-6-yl)ethynyl)cyclohexan-1-ol: 1

Experts

1.	Dahlman-Wright, Karin: 1 article (12/2015)
2.	Li, Zhilun: 1 article (12/2015)
3.	Lorent, Julie: 1 article (12/2015)
4.	Strömblad, Staffan: 1 article (12/2015)
5.	Zhao, Chunyan: 1 article (12/2015)
6.	Zhu, Jian: 1 article (12/2015)
7.	Zhuang, Ting: 1 article (12/2015)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

12/22/2015 - "Importantly, while PAK4 overexpression promoted tamoxifen resistance in MCF-7 human breast cancer cells, pharmacological treatment with a group II PAK (PAK4, 5, 6) inhibitor, GNE-2861, sensitized tamoxifen resistant MCF-7/LCC2 breast cancer cells to tamoxifen. "
12/22/2015 - "p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells."

Related Drugs and Biologics

1.	p21-Activated Kinases
2.	Estrogen Receptor alpha
3.	Tamoxifen