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imoxin

Networked: 5 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - imoxin: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - imoxin: 5

Experts

1.	Eo, Hyeyoon: 2 articles (08/2020 - 12/2018)
2.	Valentine, Rudy J: 2 articles (08/2020 - 12/2018)
3.	Jin, Lu: 1 article (01/2021)
4.	Li, Jinghui: 1 article (01/2021)
5.	Li, Qiuyu: 1 article (01/2021)
6.	Liu, Lu: 1 article (01/2021)
7.	Qu, Hai: 1 article (01/2021)
8.	Wu, Yujuan: 1 article (01/2021)
9.	Yang, Heying: 1 article (01/2021)
10.	Zhu, Ming: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 12/01/2018 - "Six-week old C57BL/6J mice received vehicle (saline) or 0.5 mg/kg imoxin 24 and 2 h prior to induction of inflammation via 1 mg/kg LPS. " 12/01/2018 - "Imoxin attenuates LPS-induced inflammation and MuRF1 expression in mouse skeletal muscle." 12/01/2018 - "Limited data are available on the efficacy of the PKR inhibitor imoxin to prevent lipopolysaccharide (LPS)-induced inflammation in skeletal muscle in vivo. " 01/01/2021 - "Six-week-old C57BL/6J mice received PKR inhibitor (imoxin) and Endoplasmic reticulum (ER) inducer (tunicamycin) 2 hr prior to induction of inflammation via cecal ligation and puncture (CLP). "
2.	Atrophy 12/01/2018 - "The aim of this study was to evaluate the effect of imoxin, a PKR inhibitor, on inflammatory and atrophy signaling in skeletal muscle in response to an acute inflammatory insult with LPS. " 12/01/2018 - "These results demonstrate the potential anti-inflammatory and anti-atrophy effects of imoxin on skeletal muscle in vivo." 08/01/2020 - "These findings suggest that imoxin may protect against DEX-induced skeletal muscle atrophy by alleviating muscle specific E3 ubiquitin ligases and imoxin alone may promote protein synthesis via Akt/mTOR/S6K1 axis in muscle cells."
3.	Muscular Atrophy (Muscle Atrophy) 08/01/2020 - "The current study aimed to investigate the effect of imoxin, a PKR inhibitor, on DEX-induced muscle atrophy in C2C12 myotubes. "
4.	Insulin Resistance 01/01/2022 - "The current study aimed to investigate the effect of imoxin (IMX), a selective PKR inhibitor, on palmitate-induced ER stress and insulin resistance in C2C12 myotubes. " 01/01/2022 - "These findings suggest that imoxin may protect against saturated fatty acid-induced ER stress and insulin resistance in skeletal muscle, which are potentially mediated by PKR." 01/01/2022 - "Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress and Insulin Resistance Are Prevented by Imoxin in C2C12 Myotubes."
5.	Hypertension (High Blood Pressure) 12/01/2020 - "Imoxin treatment was given to Wistar rats for the four weeks along with the L-NAME, to investigate the influence on the hypertension. " 12/01/2020 - "PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats."

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Palmitates
3.	Ubiquitin
4.	NG-Nitroarginine Methyl Ester (L-NAME)
5.	Tunicamycin
6.	Proteins (Proteins, Gene)
7.	Ligases (Synthetase)
8.	Fatty Acids (Saturated Fatty Acids)

Related Therapies and Procedures

1.	Punctures
2.	Ligation