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tris(2-(dimethylamino)ethyl)amine

a hematopoietic progenitor cell mobilizing agent; structure in first source

Also Known As:

Me6 compound; Me6TREN

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - tris(2-(dimethylamino)ethyl)amine: 3

Experts

1.	Basile, Patrick: 1 article (01/2020)
2.	Ebadi, Maryam: 1 article (01/2020)
3.	Fan, Zeng: 1 article (01/2020)
4.	Gordon, Peter M: 1 article (01/2020)
5.	Han, Yi: 1 article (01/2020)
6.	He, Lijuan: 1 article (01/2020)
7.	Johnson, Kimberly: 1 article (01/2020)
8.	Jonart, Leslie M: 1 article (01/2020)
9.	Li, Yanhua: 1 article (01/2020)
10.	Makori, Jessica: 1 article (01/2020)

Related Diseases

1.	Leukemia 01/01/2020 - "In addition to identifying several drugs that inhibit canonical cell adhesion targets we found that Me6TREN (Tris[2-(dimethylamino)ethyl]amine), a novel hematopoietic stem cell-mobilizing compound, also disrupted leukemia-meningeal adhesion and enhanced the efficacy of cytarabine in treating CNS leukemia in xenotransplanted mice. "
2.	Radiation Injuries (Radiation Sickness) 01/01/2020 - "Conclusion: The small molecule Me6TREN induced ISC proliferation, enhanced intestinal organoid growth in vitro, and promoted intestinal tissue regeneration after radiation injury by activating β-catenin signaling."
3.	Neoplasms (Cancer) 01/16/2014 - "Further clinical development of this new drug,Me6TREN, may have broad applications in stem-cell mobilization for cancer and in regenerative medicine."

Related Drugs and Biologics

1.	Cytarabine (Cytosar-U)
2.	Amines
3.	Catenins

Related Therapies and Procedures

1.	Hematopoietic Stem Cell Mobilization