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3-hydroxycyclopent-1-enecarboxylic acid

binds gamma-hydroxybutyrate receptors; structure in first source

Also Known As:

HOCPCA

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopentanes: 58
        3-hydroxycyclopent-1-enecarboxylic acid: 3
- Carboxylic Acids: 973
  - 3-hydroxycyclopent-1-enecarboxylic acid: 3

Experts

1.	Bach, Anders: 1 article (01/2021)
2.	Burnie, Robert O: 1 article (01/2021)
3.	Chi, Chris C: 1 article (01/2021)
4.	Clarkson, Andrew N: 1 article (01/2021)
5.	Clausen, Rasmus P: 1 article (01/2021)
6.	Frølund, Bente: 1 article (01/2021)
7.	Gauger, Stine J: 1 article (01/2021)
8.	Gee, Christine L: 1 article (01/2021)
9.	Gowing, Emma K: 1 article (01/2021)
10.	Griem-Krey, Nane: 1 article (01/2021)

Related Diseases

1.	Stroke (Strokes) 12/01/2022 - "Administration of a single dose of Ph-HTBA at a clinically relevant time point (3-6 h after photothrombotic stroke) promotes neuroprotection with a superior effect at low doses compared to the smaller GHB analog 3-hydroxycyclopent-1-enecarboxylic acid (HOCPCA). " 01/01/2023 - "Here, we report that the cyclic GHB analogue 3-hydroxycyclopent-1-enecarboxylic acid (HOCPCA), improves sensorimotor function after experimental stroke in mice when administered at a clinically relevant time and in combination with alteplase. "
2.	Brain Ischemia (Cerebral Ischemia) 01/01/2021 - "This is demonstrated in neurons exposed to excitotoxicity and in a mouse model of cerebral ischemia with the selective GHB analog, HOCPCA (3-hydroxycyclopent-1-enecarboxylic acid). " 01/01/2023 - "On the biochemical level, we observed that hub modulation by HOCPCA results in differential effects on distinct CaMKII pools, ultimately alleviating aberrant CaMKII signalling after cerebral ischemia. "
3.	Ischemia 01/01/2023 - "As such, HOCPCA normalised cytosolic Thr286 autophosphorylation after ischemia in mice and downregulated ischemia-specific expression of a constitutively active CaMKII kinase proteolytic fragment. "

Related Drugs and Biologics

1.	3-hydroxycyclopent-1-enecarboxylic acid
2.	Calcium-Calmodulin-Dependent Protein Kinase Type 2
3.	Tissue Plasminogen Activator (Alteplase)
4.	Phosphotransferases (Kinase)