1- (2- (2- methoxyphenylamino)ethylamino)- 3- (naphthalene- 1- yloxy)propan- 2- ol

01/01/2016 - "HUHS1015 significantly inhibited tumor growth in mice inoculated with CW2 cells. "
12/19/2014 - "HUHS1015 effectively suppresses tumor growth in mice inoculated with NCI-H2052, MKN45, or CW2 cells, with a potential similar to or higher than that of currently used anticancer drugs. "
07/01/2014 - "HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. "
12/19/2014 - "Here we show how HUHS1015 might offer brilliant hope for cancer therapy. "
01/01/2013 - "HUHS1015 reduced cell viability for all other investigated cancer cell lines, to an extent similar to that for malignant mesothelioma cell lines. "

03/01/2015 - "The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer."
03/01/2015 - "The results of the present study show that HUHS1015 induces caspase-independent and caspase-dependent apoptosis of MKN28 and MKN45 human gastric cancer cells, respectively, and effectively suppresses MKN45 cell proliferation. "
01/01/2015 - "The newly synthesized naftopidil analogue HUHS1015 reduced viability of MKN28 and MKN45 human gastric cancer cells in a concentration (0.3-100 μM)-dependent manner, with the potential greater than that for naftopidil. "
01/01/2015 - "HUHS1015 induces necroptosis and caspase-independent apoptosis of MKN28 human gastric cancer cells in association with AMID accumulation in the nucleus."
12/19/2014 - "HUHS1015 induces cell death in a wide variety of human cancer cell lines originated from malignant pleural mesothelioma, lung cancer, hepatoma, gastric cancer, colorectal cancer, bladder cancer, prostate cancer, and renal cancer. "

07/01/2014 - "Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma. "
07/01/2014 - "Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma."
01/01/2013 - "HUHS1015 reduced cell viability for all other investigated cancer cell lines, to an extent similar to that for malignant mesothelioma cell lines. "
01/01/2013 - "HUHS1015 activated caspase-3 and -4, without activating caspase-8 and -9, in malignant mesothelioma cell lines. "
01/01/2013 - "We newly synthesized 21 naftopidil analogues, and of them 1-[2-(2-methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol (HUHS1015) most efficiently reduced cell viability for all the investigated malignant mesothelioma cell lines in a concentration (1-100 μmol/l)-dependent manner. "

01/01/2016 - "The present study was conduced to assess the effect of HUHS1015 on human colonic cancer cells and to clarify the underlying mechanism. "
01/01/2016 - "HUHS1015 reduced cell viability of Caco-2 and CW2 human colonic cancer cell lines in a concentration (0.3-100 mM)-dependent manner. "
01/01/2016 - "HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage."

07/01/2014 - "HUHS1015 induced both necrosis and apoptosis of MSTO-211H and NCI-H2052 cells. "
01/01/2016 - "HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage."
01/01/2016 - "HUHS1015 induces necrosis by lowering the intracellular ATP level in association with mitochondrial damage and caspase-dependent apoptosis. "
01/01/2016 - "In flow cytometry using propidium iodide and annexin V, HUHS1015 significantly increased the populations of cells undergoing primary necrosis, early apoptosis, and late apoptosis/secondary necrosis in both cell lines. "
03/01/2015 - "In the flow cytometry using propidium iodide (PI) and annexin V, HUHS1015 significantly increased the population of PI-positive and annexin V-negative cells, corresponding to primary necrosis and that of PI-positive and annexin V-positive cells, corresponding to late apoptosis/secondary necrosis, both in the two cell types. "