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CH12 monoclonal antibody

directed against EGFRvIII

Also Known As:

monoclonal antibody CH12

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        CH12 monoclonal antibody: 6
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        CH12 monoclonal antibody: 6
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        CH12 monoclonal antibody: 6

Experts

1.	Jiang, Hua: 6 articles (02/2019 - 02/2011)
2.	Li, Zonghai: 5 articles (02/2019 - 02/2011)
3.	Shi, Bizhi: 4 articles (02/2019 - 02/2011)
4.	Gao, Huiping: 3 articles (02/2019 - 06/2012)
5.	Wang, Huamao: 3 articles (01/2018 - 02/2011)
6.	Dong, Qiongna: 2 articles (02/2019 - 01/2014)
7.	Luo, Xiaoying: 2 articles (02/2019 - 01/2014)
8.	Kong, Juan: 2 articles (01/2014 - 06/2012)
9.	Hu, Suwen: 2 articles (06/2012 - 02/2011)
10.	Zhou, Min: 1 article (02/2019)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2019 - "Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2014 - "The monoclonal antibody CH12 augments 5-fluorouracil-induced growth suppression of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III." 02/18/2011 - "Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III." 06/01/2012 - "The monoclonal antibody CH12 enhances the sorafenib-mediated growth inhibition of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III."
3.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2019 - "Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12."
4.	Thrombocytopenia (Thrombopenia) 01/01/2018 - "Species-Specific Involvement of Integrin αIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys."
5.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2011 - "To investigate the effect of a monoclonal antibody (CH12), targeted against epidermal growth factor receptor type III variant (EGFRvIII), on human ovarian cancer cells when administered in combination with cisplatin chemotherapy. "

Related Drugs and Biologics

1.	Epitopes
2.	ErbB Receptors (EGF Receptor)
3.	Integrins
4.	Cisplatin (Platino)
5.	Sorafenib (BAY 43-9006)
6.	epidermal growth factor receptor VIII

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)