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(1- (chloromethyl)- 1,2- dihydropyrrolo(3,2- e)indol- 3(6H)- yl)(5- fluoro- 1H- indol- 2- yl)methanone

rendered into a cytotoxic compounds by CYP2W1; structure in first source

Also Known As:

ICT2705

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - (1-(chloromethyl)-1,2-dihydropyrrolo(3,2-e)indol-3(6H)-yl)(5-fluoro-1H-indol-2-yl)methanone: 1
  - 3-Ring Heterocyclic Compounds
    - (1-(chloromethyl)-1,2-dihydropyrrolo(3,2-e)indol-3(6H)-yl)(5-fluoro-1H-indol-2-yl)methanone: 1

Experts

1.	Alandas, Mohammed N: 1 article (06/2013)
2.	Ingelman-Sundberg, Magnus: 1 article (06/2013)
3.	Johansson, Inger: 1 article (06/2013)
4.	Loadman, Paul M: 1 article (06/2013)
5.	Mkrtchian, Souren: 1 article (06/2013)
6.	Patterson, Laurence H: 1 article (06/2013)
7.	Pors, Klaus: 1 article (06/2013)
8.	Sheldrake, Helen M: 1 article (06/2013)
9.	Shnyder, Steven D: 1 article (06/2013)
10.	Travica, Sandra: 1 article (06/2013)

Related Diseases

1.

Colonic Neoplasms (Colon Cancer)

06/01/2013 - "The cytotoxic activity of ICT2705 and ICT2706 in vitro was tested in colon cancer cell lines expressing CYP2W1, and in vivo studies with ICT2706 were conducted on severe combined immunodeficient mice bearing CYP2W1-positive colon cancer xenografts. "
06/01/2013 - "Cells expressing CYP2W1 suffer rapid loss of viability following treatment with ICT2705 and ICT2706, whereas the CYP2W1-positive human colon cancer xenografts display arrested growth in the mice treated with ICT2706. "

Related Drugs and Biologics

1.	(5- chloro- 1H- indol- 2- yl)(1- (chloromethyl)- 1,2- dihydropyrrolo(3,2- e)indol- 3(6H)- yl)methanone