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N- (5- (3- (3- cyanophenyl)imidazo(1,2- a)pyridin- 6- yl)pyridin- 3- yl)benzenesulfonamide

structure in first source

Also Known As:

HS-159

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hong, Soon-Sun: 1 article (07/2013)
2.	Hong, Sungwoo: 1 article (07/2013)
3.	Jung, Kyung Hee: 1 article (07/2013)
4.	Lee, Hyunseung: 1 article (07/2013)
5.	Lee, Ju-Hee: 1 article (07/2013)
6.	Lee, Soyoung: 1 article (07/2013)
7.	Yun, Sun-Mi: 1 article (07/2013)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/01/2013 - "In this study, we synthesized a novel PI3Kα inhibitor, HS-159 [N-(5-(3-(3-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide] and evaluated its anticancer effects on Huh-7 human hepatocellular carcinoma (HCC) cells. " 07/01/2013 - "Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor."
2.	Hypoxia (Hypoxemia) 07/01/2013 - "This compound also induced apoptosis and increased the fraction of apoptotic cells in the sub-G1 phase as well as the levels of cleaved PARP, caspase-3 and -9. Furthermore, HS-159 decreased the expression of hypoxia inducible factor-1α and vascular endothelial growth factor which play important roles in angiogenesis. "

Related Drugs and Biologics

1.	Benzenesulfonamides
2.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
3.	Caspase 3 (Caspase-3)
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)