9- (hydroxymethyl)- 3- (1- adamantyl)hexahydrocannabinol

Also Known As:

AM 4054; AM4054

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Cannabinoids: 5901
      - Cannabinol: 55
        9-(hydroxymethyl)-3-(1-adamantyl)hexahydrocannabinol: 3
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        9-(hydroxymethyl)-3-(1-adamantyl)hexahydrocannabinol: 3
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        9-(hydroxymethyl)-3-(1-adamantyl)hexahydrocannabinol: 3

Experts

1.	Makriyannis, Alexandros: 3 articles (08/2013 - 01/2013)
2.	Thakur, Ganesh A: 3 articles (08/2013 - 01/2013)
3.	Vemuri, V Kiran: 3 articles (08/2013 - 01/2013)
4.	Bajaj, Shama: 2 articles (02/2013 - 01/2013)
5.	Bergman, Jack: 2 articles (02/2013 - 01/2013)
6.	Brown, Cara M: 1 article (08/2013)
7.	McClure, Evan D: 1 article (08/2013)
8.	McLaughlin, Peter J: 1 article (08/2013)
9.	Salamone, John D: 1 article (08/2013)
10.	Winston, Keisha M: 1 article (08/2013)

Related Diseases

1.	Shock 02/01/2013 - "In the present studies, the effects of CB(1) agonists [(6aR,10aR)-3-(1-adamantyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol (AM411), 9β-(hydroxymethyl)-3-(1-adamantyl)-hexahydrocannabinol (AM4054), R-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate (WIN55,212.2), Δ(9)-tetrahydrocannabinol (Δ(9)-THC), (R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide (methanandamide)], CB(1) antagonists [5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (SR141716A), 5-(4-alkylphenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (AM4113)], and dopamine (DA)-related [methamphetamine, (±)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (SKF82958), (R)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390), (6aR)-5,6,6a,7-tetrahydro-6-propyl-4H-dibenzo[de,g]quinoline-10,11-diol (R-(-)-NPA), haloperidol] and opioid (morphine, naltrexone) drugs on scheduled-controlled responding under a 30-response fixed ratio schedule of stimulus-shock termination in squirrel monkeys were compared before and during chronic treatment with the long-acting CB(1) agonist AM411 (1.0 mg/kg per day, i.m.). "
2.	Hypothermia 08/01/2013 - "In Experiment 1, a dose range (0.15625-1.25 mg/kg) of AM 4054 produced effects consistent with CB1 agonism in the cannabinoid tetrad of tasks in rats, including induction of analgesia, catalepsy, hypothermia, and locomotor suppression. " 01/01/2013 - "Direct-acting CB1 agonists, including Δ(9)-tetrahydrocannabinol, WIN 55,212 [R-(1)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate], AM2389 [9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol], and AM4054 [9β-(hydroxymethyl)-3-(1-adamantyl)-hexahydrocannabinol], produced dose-dependent increases in diuresis and decreases in colonic temperature, with slightly lower ED(50) values for diuresis than for hypothermia. "
3.	Catalepsy 08/01/2013 - "In Experiment 1, a dose range (0.15625-1.25 mg/kg) of AM 4054 produced effects consistent with CB1 agonism in the cannabinoid tetrad of tasks in rats, including induction of analgesia, catalepsy, hypothermia, and locomotor suppression. "

Related Drugs and Biologics

1.	Mesylates (Mesylate)
2.	Naltrexone (ReVia)
3.	Morphine (MS Contin)
4.	Methamphetamine (Desoxyn)
5.	Haloperidol (Haldol)
6.	Dopamine (Intropin)
7.	Opioid Analgesics (Opioids)
8.	Rimonabant
9.	SCH 23390
10.	AM4113

Related Therapies and Procedures

1.	Analgesia