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methyl 3- (N- (4- (hexylamino)- 2- methoxyphenyl)sulfamoyl)thiophene- 2- carboxylate

a PPAR beta/delta inverse agonist; structure in first source

Also Known As:

ST247

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate: 2
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate: 2
  - Thiophenes: 257
    - methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate: 2

Experts

1.	Adhikary, T: 1 article (10/2013)
2.	Brandt, D T: 1 article (10/2013)
3.	Diederich, W E: 1 article (10/2013)
4.	Finkernagel, F: 1 article (10/2013)
5.	Grosse, R: 1 article (10/2013)
6.	Jarek, M: 1 article (10/2013)
7.	Kaddatz, K: 1 article (10/2013)
8.	Lieber, S: 1 article (10/2013)
9.	Meissner, W: 1 article (10/2013)
10.	Müller, R: 1 article (10/2013)

Related Diseases

1.	Pneumonia (Pneumonitis) 03/01/2011 - "Pneumococci of serotypes 1 (Sweden(1)-ST306), 4 (ST247(4)), 5 (Colombia(5)-ST289) and 8 (Netherlands(8)-ST53) were more often associated with pneumonia. "
2.	Neoplasms (Cancer) 10/31/2013 - "Repression of ANGPTL4 transcription by inverse PPARβ/δ agonists is functionally linked to the inhibition of cancer cell invasion into a three-dimensional matrix, as (i) invasion of MDA-MB-231 cells is critically dependent on ANGPTL4 expression, (ii) recombinant ANGPTL4 stimulates invasion, and (iii) reverses the inhibitory effect of ST247 and DG172. "
3.	Breast Neoplasms (Breast Cancer) 10/31/2013 - "We show that two structurally divergent inhibitory ligands for PPARβ/δ, the inverse agonists ST247 and DG172, strongly inhibit the serum- and transforming growth factor β (TGFβ)-induced invasion of MDA-MB-231 human breast cancer cells into a three-dimensional matrigel matrix. "

Related Drugs and Biologics

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4.	matrigel