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3- (8- (2- (cyclohexylmethyl(2,3- dihydroxypropionyl)amino)ethyl)- 8- azabicyclo(3.2.1)oct- 3- yl)benzamide

Also Known As:

3-endo-(8-(2-(cyclohexylmethyl-((S)-2,3-dihydroxypropionyl)amino)ethyl)-8-azabicyclo(3.2.1)oct-3-yl)benzamide; TD-1211

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Tropanes: 1
    - 3-(8-(2-(cyclohexylmethyl(2,3-dihydroxypropionyl)amino)ethyl)-8-azabicyclo(3.2.1)oct-3-yl)benzamide: 1
- Bridged-Ring Heterocyclic Compounds
  - Tropanes: 1
    - 3-(8-(2-(cyclohexylmethyl(2,3-dihydroxypropionyl)amino)ethyl)-8-azabicyclo(3.2.1)oct-3-yl)benzamide: 1
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - Tropanes: 1
        3-(8-(2-(cyclohexylmethyl(2,3-dihydroxypropionyl)amino)ethyl)-8-azabicyclo(3.2.1)oct-3-yl)benzamide: 1

Experts

1.	Armstrong, Scott R: 1 article (06/2013)
2.	Beattie, David T: 1 article (06/2013)
3.	Campbell, Christina B: 1 article (06/2013)
4.	Hegde, Sharath S: 1 article (06/2013)
5.	Long, Daniel D: 1 article (06/2013)
6.	Richardson, Carrie L: 1 article (06/2013)
7.	Tsuruda, Pamela R: 1 article (06/2013)
8.	Vickery, Ross G: 1 article (06/2013)

Related Diseases

1.	Hypothermia 06/01/2013 - "Oral administration of naltrexone and ADL 08-0011, but not TD-1211 or alvimopan, was associated with a CNS withdrawal response in morphine-dependent mice, inhibition of morphine-induced anti-nociception in rat and dog hot plate tests, and hypothermia and sedation in dogs. "
2.	Diarrhea 06/01/2013 - "Oral administration of TD-1211, naltrexone, and ADL 08-0011 reversed loperamide-induced inhibition of gastric emptying and castor oil-induced diarrhea in rats and nonproductive GI circular smooth muscle contractility in dogs. "
3.	Opioid-Induced Constipation 06/01/2013 - "The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of opioid-induced constipation, was compared to that of the clinically studied opioid antagonists, naltrexone, alvimopan, and ADL 08-0011 (the primary active metabolite of alvimopan). "

Related Drugs and Biologics

1.	Narcotic Antagonists (Opioid Antagonists)
2.	Naltrexone (ReVia)
3.	Morphine (MS Contin)
4.	Loperamide (Imodium)
5.	Castor Oil (Oil, Castor)
6.	ADL 08-0011
7.	alvimopan

Related Therapies and Procedures

1.	Oral Administration