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2-acetylphenothiazine

Also Known As:

2-APT compound; ML171

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Phenothiazines: 506
    - 2-acetylphenothiazine: 12
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenothiazines: 506
      - 2-acetylphenothiazine: 12

Experts

1.	Furuta, Yoshikazu: 1 article (01/2022)
2.	Higashi, Hideaki: 1 article (01/2022)
3.	Ito, Koki: 1 article (01/2022)
4.	Nakamura, Shinji: 1 article (01/2022)
5.	Okubo, Torahiko: 1 article (01/2022)
6.	Thapa, Jeewan: 1 article (01/2022)
7.	Yamaguchi, Hiroyuki: 1 article (01/2022)
8.	Yoshiiri, Gen: 1 article (01/2022)
9.	Ahn, Ji-Sun: 1 article (01/2021)
10.	Cho, Jang-Hee: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "The toxicity of a single dose of ML171 was evaluated in 6-week-old Institute of Cancer Research (ICR) mice in a good laboratory practice (GLP) laboratory. " 01/01/2019 - "WT mice given DEN followed by ML171 developed fewer and smaller liver tumors than mice given DEN followed by vehicle. " 10/15/2010 - "These results elucidate the relevance of Nox1-dependent ROS generation in mechanisms of cancer invasion and define ML171 as a useful Nox1 chemical probe and potential therapeutic agent for inhibition of cancer cell invasion."
2.	Fibrosis (Cirrhosis) 01/01/2022 - "In particular, a specific NOX1 inhibitor, ML171, effectively decreased myocardial fibrosis and protected against cardiac dysfunction in DCM rats. " 11/01/2020 - "Subsequently, we used pharmacological inhibitors of Nox1 (ML171) and Nox1/Nox4 (GKT137831; 60 mg/kg), to modulate NADPH oxidase activity at the early stage of spontaneous hypertension and investigated their effects on perivascular inflammation and fibrosis. "
3.	Chronic Renal Insufficiency 05/01/2020 - "Abbreviations: CKD: Chronic kidney disease; IS: Indoxyl sulfate; ROS: Reactive oxygen species; NOX: NADH oxidase; OATP2B1: Organic anion transporting polypeptide2B1; PKC: Protein kinase C; PI3K: Phosphoinositide 3-kinase; 2-APT: 2-acetylphenothiazine."
4.	Thrombosis (Thrombus) 01/01/2013 - "The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner."
5.	Pain (Aches) 10/01/2019 - "Here, we investigated anti-nociceptive potential of a newly identified specific NOX1 inhibitor ML171 in formalin induced inflammatory pain. "

Related Drugs and Biologics

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2.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
3.	Small Interfering RNA (siRNA)
4.	NADPH Oxidases (NAD(P)H oxidase)
5.	Chemokines
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Protein Kinase C
8.	Indican
9.	Formaldehyde (Formol)
10.	Anions