1- (4- (6- (2- (isopropylsulfonyl)phenylamino)- 9H- purin- 2- ylamino)- 3- ethoxyphenyl)piperidin- 4- ol
an MPS1 inhibitor that sensitizes glioblastoma cells to antimitotic drugs; structure in first source
Networked: 1
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
| 1. | Barazas, Marco:
1 article
(09/2013)
|
| 2. | De Witt Hamer, Philip C:
1 article
(09/2013)
|
| 3. | Geerts, Dirk:
1 article
(09/2013)
|
| 4. | Gray, Nathanael S:
1 article
(09/2013)
|
| 5. | Hagemann, Carsten:
1 article
(09/2013)
|
| 6. | Hiddingh, Lotte:
1 article
(09/2013)
|
| 7. | Kerami, Mariam:
1 article
(09/2013)
|
| 8. | Kessler, Almuth F:
1 article
(09/2013)
|
| 9. | Kwiatkowski, Nicholas:
1 article
(09/2013)
|
| 10. | Lagerweij, Tonny:
1 article
(09/2013)
|
Related Diseases
| 1. | Glioblastoma (Glioblastoma Multiforme)
09/04/2013
- " Our results collectively demonstrate that MPS1, a putative therapeutic target in glioblastoma, can be selectively inhibited by MPS1-IN-3 sensitizing glioblastoma cells to antimitotic drugs." 09/04/2013
- " MPS1-IN-3 sensitizes glioblastoma cells to vincristine in orthotopic mouse models (two-sided log-rank test, P < .01), resulting in prolonged survival without toxicity. " 09/04/2013
- " Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs." 09/04/2013
- " We developed a selective small-molecule inhibitor of MPS1, MPS1-IN-3, which caused mitotic aberrancies in glioblastoma cells and, in combination with vincristine, induced mitotic checkpoint override, increased aneuploidy, and augmented cell death. "
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| 2. | Aneuploidy (Aneuploid)
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