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UCCB01-125

inhibits postsynaptic density protein-95 (PSD-95); structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Andreasen, Jesper T: 2 articles (06/2016 - 04/2013)
2.	Bach, Anders: 2 articles (06/2016 - 04/2013)
3.	Gynther, Mikko: 2 articles (06/2016 - 04/2013)
4.	Nasser, Arafat: 2 articles (06/2016 - 04/2013)
5.	Pickering, Darryl S: 2 articles (06/2016 - 04/2013)
6.	Strømgaard, Kristian: 2 articles (06/2016 - 04/2013)
7.	Caballero-Puntiverio, Maitane: 1 article (06/2016)
8.	Sahlholt, Maj: 1 article (06/2016)
9.	Mogensen, Jesper: 1 article (04/2013)

Related Diseases

1.	Pain (Aches) 06/05/2016 - "We recently reported that UCCB01-125, a dimeric PSD-95 inhibitor with limited blood-brain-barrier permeability, reduced mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model, without disrupting cognitive or motor functions. " 04/01/2013 - "UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801." 04/01/2013 - "Here, we compared the effects of a dimeric PSD-95 inhibitor, UCCB01-125, and the NMDAR antagonist, MK-801, on mechanical hypersensitivity in the complete Freund's adjuvant (CFA) model of inflammatory pain. "
2.	Hypersensitivity (Allergy) 06/05/2016 - "UCCB01-125 did not affect SNI-induced hypersensitivity. " 04/01/2013 - "Moreover, UCCB01-125 was found to reverse CFA-induced hypersensitivity when administered 24 h after CFA treatment, an effect lasting for at least 3 days. " 04/01/2013 - "When administered concurrently with CFA, both MK-801 and UCCB01-125 prevented the development of CFA-induced mechanical hypersensitivity 1 and 24 h after treatment. " 06/05/2016 - "We recently reported that UCCB01-125, a dimeric PSD-95 inhibitor with limited blood-brain-barrier permeability, reduced mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model, without disrupting cognitive or motor functions. " 04/01/2013 - "Here, we compared the effects of a dimeric PSD-95 inhibitor, UCCB01-125, and the NMDAR antagonist, MK-801, on mechanical hypersensitivity in the complete Freund's adjuvant (CFA) model of inflammatory pain. "
3.	Neuralgia (Stump Neuralgia) 06/05/2016 - "To extend the comparison of UCCB01-125 and UCCB01-144, we also tested both compounds in the spared nerve injury (SNI) model of neuropathic pain. "

Related Drugs and Biologics

1.	Freund's Adjuvant
2.	Dizocilpine Maleate (Dizocilpine)
3.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
4.	UCCB01-144

Related Therapies and Procedures

1.	Aftercare (After-Treatment)