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calabadion 1

reverses benzylisoquinoline and steroidal neuromuscular-blocking agent effects; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - calabadion 1: 1
Inorganic Chemicals: 9
- Acids: 53217
  - Noncarboxylic Acids
    - Sulfur Acids
      - Sulfonic Acids: 1605
        calabadion 1: 1
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - calabadion 1: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - calabadion 1: 1

Experts

1.	Akeju, Oluwaseun: 1 article (01/2020)
2.	Boghosian, James D: 1 article (01/2020)
3.	Cotten, Joseph F: 1 article (01/2020)
4.	Eikermann, Matthias: 1 article (01/2020)
5.	Gill, Monica: 1 article (01/2020)
6.	Grabitz, Stephanie D: 1 article (01/2020)
7.	Isaacs, Lyle: 1 article (01/2020)
8.	Rostin, Paul: 1 article (01/2020)
9.	Santer, Peter: 1 article (01/2020)
10.	Thevathasan, Tharusan: 1 article (01/2020)

Related Diseases

1.	Respiratory Insufficiency (Respiratory Failure) 01/01/2020 - "The effective Calabadion 1 doses required to reverse respiratory depression by 50% and 90% (ED50Res and ED90Res) were 1.7 and 15.6 mg kg-1, respectively. " 01/01/2020 - "Calabadion 1 reversed fentanyl-induced respiratory depression across the endpoints minute ventilation, pH, and Paco2 (P=0.001). " 01/01/2020 - "We hypothesised that Calabadion 1, an acyclic cucurbit[n]uril molecular container, reverses fentanyl-induced respiratory depression and dysfunction of the CNS. "
2.	Muscle Rigidity 01/01/2020 - "Calabadion 1 also significantly accelerated recovery of full functional mobility and reversal of muscle rigidity. "
3.	Hypoventilation 01/01/2020 - "Compared with placebo, Calabadion 1 dose dependently (P for trend <0.001) reversed fentanyl-induced hypoventilation {81.9 [5.1] (mean [standard error of the mean]) vs 45.5 [12.4] ml min-1; P<0.001}, acidosis (pH 7.43 [0.01] vs 7.28 [0.04]; P=0.005), and hypercarbia (Paco2 43.4 [1.6] vs 63.4 [8.1] mm Hg; P=0.018). "
4.	Acidosis 01/01/2020 - "Compared with placebo, Calabadion 1 dose dependently (P for trend <0.001) reversed fentanyl-induced hypoventilation {81.9 [5.1] (mean [standard error of the mean]) vs 45.5 [12.4] ml min-1; P<0.001}, acidosis (pH 7.43 [0.01] vs 7.28 [0.04]; P=0.005), and hypercarbia (Paco2 43.4 [1.6] vs 63.4 [8.1] mm Hg; P=0.018). "

Related Drugs and Biologics

1.	Fentanyl (Sublimaze)
2.	cucurbit(n)uril (cucurbituril)