millepachine

11/12/2023 - "Preclinical studies have shown that Millepachine and its derivatives offer exceptional potential for treating a number of cancers. "
11/12/2023 - "The potential of Millepachine and its derivatives to treat various malignancies has been demonstrated in this review. "
02/03/2023 - "Among all the compounds, compound 14b exhibited the most potent cytotoxic activity against five kinds of human cancer cell lines, with IC50 values ranging from 0.022 to 0.074 μM, making it almost 100 times more active than millepachine. "
01/01/2018 - "The effect and mechanism of millepachine-disrupted spindle assembly in tumor cells."
08/01/2012 - "Among these novel derivatives, 15 displayed more potent antiproliferative activity than millepachine against HepG2, K562, SK-OV-3, HCT116, HT29, and SW620 tumor cells (mean IC(50) = 0.64 vs. 2.86 μM, respectively). "

08/09/2016 - "Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer."
11/12/2023 - "The anticancer effects of Millepachine and its derivatives on ovarian cancer, hepatocellular carcinoma, breast, liver, colon, cervical, prostate, stomach, and gliomas are highlighted in the current review. "
12/01/2018 - "Millepachine showed novel antitumor effects in cisplatin-resistant human ovarian cancer through inhibiting drug efflux function of ATP-binding cassette transporters."

11/12/2023 - "The anticancer effects of Millepachine and its derivatives on ovarian cancer, hepatocellular carcinoma, breast, liver, colon, cervical, prostate, stomach, and gliomas are highlighted in the current review. "
05/05/2021 - "MIL-1, a novel antitumor agent derived from natural product millepachine, acts as tubulin polymerization inhibitor for the treatment of hepatocellular carcinoma."

01/01/2014 - "SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. "

11/12/2023 - "The anticancer effects of Millepachine and its derivatives on ovarian cancer, hepatocellular carcinoma, breast, liver, colon, cervical, prostate, stomach, and gliomas are highlighted in the current review. "